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公开(公告)号：US5039664A
公开(公告)日：1991-08-13
申请号：US320666
申请日：1989-03-08
IPC分类号： C07K5/02
CPC分类号： C07K5/0207
摘要： Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.
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公开(公告)号：US5037807A
公开(公告)日：1991-08-06
申请号：US320681
申请日：1989-03-08
IPC分类号： C07K5/02
CPC分类号： C07K5/0207
摘要： Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.
摘要翻译： 其包含新型元件的肽，其包含基于底物类比替代肾素抑制肽中的Phe（8）-His（9）序列的新元件，其抑制肾素的底物切割作用并具有改善的生物利用度; 含有这些肾素抑制肽的组合物，任选与其它抗高血压药物组合; 以及在使用新型肽的这些问题中治疗高血压或充血性心力衰竭或建立肾素作为致病因素的方法。
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公开(公告)号：US4839357A
公开(公告)日：1989-06-13
申请号：US102203
申请日：1987-10-02
IPC分类号： C07K5/02
CPC分类号： C07K5/0207 , Y10S530/86
摘要： Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.
摘要翻译： 其包含新型元件的肽，其包含基于底物类比替代肾素抑制肽中的Phe（8）-His（9）序列的新元件，其抑制肾素的底物切割作用并具有改善的生物利用度; 含有这些肾素抑制肽的组合物，任选与其它抗高血压药物组合; 以及在使用新型肽的这些问题中治疗高血压或充血性心力衰竭或建立肾素作为致病因素的方法。
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4.发明授权Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists 失效作为血管紧张素II拮抗剂的取代的三唑啉酮，三唑啉硫酮和三唑啉亚胺
公开(公告)号：US5411980A
公开(公告)日：1995-05-02
申请号：US994228
申请日：1992-12-21
申请人： Wallace T. Ashton , Linda L. Chang , Malcolm MacCoss , Prasun K. Chakravarty , William J. Greenlee , Arthur A. Patchett , Kelly Flanagan
发明人： Wallace T. Ashton , Linda L. Chang , Malcolm MacCoss , Prasun K. Chakravarty , William J. Greenlee , Arthur A. Patchett , Kelly Flanagan
IPC分类号： C07D249/12 , C07D249/14 , C07D401/14 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/41
CPC分类号： C07D401/14 , C07D249/12 , C07D249/14 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/10
摘要： There are disclosed new substituted triazolinone, triazolinethione, and triazolinimine compounds which are useful as angiotensin II antagonists. These compounds have the general formula: ##STR1## wherein G is R.sup.1 or ##STR2##
摘要翻译： 公开了可用作血管紧张素II拮抗剂的新的取代的三唑啉酮，三唑啉硫酮和三唑啉亚胺化合物。 这些化合物具有以下通式：其中G为R 1或
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公开(公告)号：US5240928A
公开(公告)日：1993-08-31
申请号：US665518
申请日：1991-03-06
申请人： Eric E. Allen , Stephen E. de Laszlo , Prasun K. Chakravarty , William J. Greenlee , Arthur A. Patchett , Thomas F. Walsh
发明人： Eric E. Allen , Stephen E. de Laszlo , Prasun K. Chakravarty , William J. Greenlee , Arthur A. Patchett , Thomas F. Walsh
IPC分类号： C07D239/70 , C07D239/90 , C07D239/91 , C07D403/10
CPC分类号： C07D403/10 , C07D239/70 , C07D239/90 , C07D239/91
摘要： Novel substituted quinazolinones of the formula (I), which are useful as angiotensin II antagonists, are disclosed. ##STR1##
摘要翻译： 公开了可用作血管紧张素II拮抗剂的式（I）的新型取代喹唑啉酮。 （一）
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公开(公告)号：US5157026A
公开(公告)日：1992-10-20
申请号：US840241
申请日：1992-02-24
申请人： Prasun K. Chakravarty , William J. Greenlee , Nathan B. Mantlo , Arthur A. Patchett , Thomas F. Walsh
发明人： Prasun K. Chakravarty , William J. Greenlee , Nathan B. Mantlo , Arthur A. Patchett , Thomas F. Walsh
IPC分类号： C07D471/04 , C07D473/00 , C07D473/04 , C07D473/30 , C07D473/32 , C07D473/40 , C07F9/6561
CPC分类号： C07D471/04 , C07D473/00 , C07D473/04 , C07D473/30 , C07D473/32 , C07D473/40 , C07F9/6561
摘要： Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
摘要翻译： 取代的具有结构式的咪唑并稠合的6元杂环：其中A，B，C和D独立地为碳原子或氮原子是可用于治疗高血压和充血性心力衰竭的血管紧张素II拮抗剂。
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7.发明授权
公开(公告)号：US5126342A
公开(公告)日：1992-06-30
申请号：US590971
申请日：1990-10-01
申请人： Prasun K. Chakravarty , William J. Greenlee , Elizabeth M. Naylor , Arthur A. Patchett , Thomas F. Walsh
发明人： Prasun K. Chakravarty , William J. Greenlee , Elizabeth M. Naylor , Arthur A. Patchett , Thomas F. Walsh
IPC分类号： A61K31/415 , A61K31/675 , A61K45/06 , A61P3/00 , A61P9/12 , A61P27/02 , A61P43/00 , C07D233/54 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/84 , C07D233/88 , C07D233/90 , C07D403/04 , C07D403/06 , C07D403/12 , C07D407/04 , C07D521/00 , C07F9/6506
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D233/68 , C07D233/88 , C07D233/90 , C07D249/08 , C07D403/04 , C07D403/06 , C07F9/65061
摘要： There are disclosed substituted imidazole derivatives of Formula I which are useful as angiotensin II antagonists. ##STR1##
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8.发明授权Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists 失效带有酸性官能团的杂环化合物作为血管紧张素II拮抗剂
公开(公告)号：US5412097A
公开(公告)日：1995-05-02
申请号：US940267
申请日：1992-09-02
申请人： Prasun K. Chakravarty , William J. Greenlee , Dooseop Kim , Nathan B. Mantlo , Arthur A. Patchett , Ralph A. Rivero
发明人： Prasun K. Chakravarty , William J. Greenlee , Dooseop Kim , Nathan B. Mantlo , Arthur A. Patchett , Ralph A. Rivero
IPC分类号： C07D471/04 , C07D473/08 , C07D473/32 , C07F9/6561 , A61K31/435 , A61K31/52 , C07D473/00
CPC分类号： C07D471/04 , C07D473/08 , C07D473/32 , C07F9/6561
摘要： Heterocyclic compounds of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
摘要翻译： 结构式的杂环化合物：其中A，B，C和D独立地为碳原子或氮原子，可用于治疗高血压和充血性心力衰竭的血管紧张素II拮抗剂。
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9.发明授权Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists 失效在5位含有酸性官能团的咪唑衍生物，其作为血管紧张素II拮抗剂的组合物和用途
公开(公告)号：US5236928A
公开(公告)日：1993-08-17
申请号：US891668
申请日：1992-05-29
IPC分类号： C07D233/84 , C07D233/90 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/12
CPC分类号： C07D403/10 , C07D233/84 , C07D233/90 , C07D403/12 , C07D403/14 , C07D413/10
摘要： There are disclosed substituted imidazole derivatives of Formula I bearing acidic functional groups which are useful as angiotensin II antagonists. ##STR1##
摘要翻译： 公开了具有酸性官能团的式I的取代咪唑衍生物，其可用作血管紧张素II拮抗剂。
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10.发明授权Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists 失效取代的咪唑并稠合的6元杂环作为血管紧张素II拮抗剂
公开(公告)号：US5332744A
公开(公告)日：1994-07-26
申请号：US516286
申请日：1990-05-04
申请人： Prasun K. Chakravarty , William J. Greenlee , Nathan B. Mantlo , Arthur A. Patchett , Thomas F. Walsh
发明人： Prasun K. Chakravarty , William J. Greenlee , Nathan B. Mantlo , Arthur A. Patchett , Thomas F. Walsh
IPC分类号： C07D471/04 , C07D473/00 , C07D473/04 , C07D473/30 , C07D473/32 , C07D473/40 , C07F9/6561 , A61K31/435 , A61K31/52
CPC分类号： C07D471/04 , C07D473/00 , C07D473/04 , C07D473/30 , C07D473/32 , C07D473/40 , C07F9/6561
摘要： Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
摘要翻译： 取代的具有结构式的咪唑并稠合的6元杂环：其中A，B，C和D独立地为碳原子或氮原子，可用于治疗高血压和充血性心力衰竭的血管紧张素II拮抗剂。
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