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1.Antagonists of the vanilloid receptor subtype 1 (VR1) and use thereof 有权
标题翻译: 香草素受体亚型1(VR1)的拮抗剂及其用途公开(公告)号:US07902236B2
公开(公告)日:2011-03-08
申请号:US12365643
申请日:2009-02-04
申请人: Arthur Gomtsyan , Richard J. Perner , John R. Koenig , Margaret Chi-Ping Hsu , Dilinie P. Fernando , Chih-Hung Lee
发明人: Arthur Gomtsyan , Richard J. Perner , John R. Koenig , Margaret Chi-Ping Hsu , Dilinie P. Fernando , Chih-Hung Lee
IPC分类号: A61K31/426 , A61K31/421
CPC分类号: C07D263/48
摘要: The present invention is directed to compounds of formula (I) wherein variables W, X, Y, D, A, n, R1, R2 and R9 are as defined in the description.
摘要翻译: 本发明涉及式(I)化合物,其中变量W,X,Y,D,A,n,R 1,R 2和R 9如说明书中所定义。
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2.ANTAGONISTS OF THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USE THEREOF 审中-公开
标题翻译: VANILLOID受体亚型1(VR1)的拮抗剂及其用途公开(公告)号:US20110144057A1
公开(公告)日:2011-06-16
申请号:US13023186
申请日:2011-02-08
申请人: Arthur Gomtsyan , Richard J. Perner , John R. Koenig , Margaret Chi-Ping Hsu , Dilinie P. Fernando , Chih-Hung Lee
发明人: Arthur Gomtsyan , Richard J. Perner , John R. Koenig , Margaret Chi-Ping Hsu , Dilinie P. Fernando , Chih-Hung Lee
IPC分类号: A61K31/695 , C07D263/30 , A61K31/421 , C07F7/18 , A61P29/00 , A61P13/10
CPC分类号: C07D263/48
摘要: The present invention is directed to compounds of formula (I) wherein variables W, X, Y, D, A, n, R1, R2 and R9 are as defined in the description.
摘要翻译: 本发明涉及式(I)化合物,其中变量W,X,Y,D,A,n,R 1,R 2和R 9如说明书中所定义。
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3.Antagonists of the vanilloid receptor subtype 1 (VR1) and use thereof 有权
标题翻译: 香草素受体亚型1(VR1)的拮抗剂及其用途公开(公告)号:US07504520B2
公开(公告)日:2009-03-17
申请号:US11431459
申请日:2006-05-10
申请人: Arthur Gomtsyan , Richard J. Perner , John R. Koenig , Margaret Chi-Ping Hsu , Dilinie P. Fernando , Chih-Hung Lee
发明人: Arthur Gomtsyan , Richard J. Perner , John R. Koenig , Margaret Chi-Ping Hsu , Dilinie P. Fernando , Chih-Hung Lee
IPC分类号: C07D209/04 , C07D421/00 , C07D277/00 , C07D295/00 , C07D409/00 , C07D207/46
CPC分类号: C07D263/48
摘要: The present invention is directed to compounds of formula (I) wherein variables W, X, Y, D, A, n, R1, R2 and R9 are as defined in the description.
摘要翻译: 本发明涉及式(I)化合物,其中变量W,X,Y,D,A,n,R 1,R 2和R 9如说明书中所定义。
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4.ANTAGONISTS OF THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USE THEREOF 有权
标题翻译: VANILLOID受体亚型1(VR1)的拮抗剂及其用途公开(公告)号:US20100010055A1
公开(公告)日:2010-01-14
申请号:US12365643
申请日:2009-02-04
申请人: Arthur Gomtsyan , Richard J. Perner , John R. Koenig , Margaret Chi-Ping Hsu , Dilinie P. Fernando , Chih-Hung Lee
发明人: Arthur Gomtsyan , Richard J. Perner , John R. Koenig , Margaret Chi-Ping Hsu , Dilinie P. Fernando , Chih-Hung Lee
IPC分类号: A61K31/426 , A61K31/421 , A61P29/00 , A61P13/00
CPC分类号: C07D263/48
摘要: The present invention is directed to compounds of formula (I) wherein variables W, X, Y, D, A, n, R1, R2 and R9 are as defined in the description.
摘要翻译: 本发明涉及式(I)化合物,其中变量W,X,Y,D,A,n,R 1,R 2和R 9如说明书中所定义。
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公开(公告)号:US07998993B2
公开(公告)日:2011-08-16
申请号:US12256931
申请日:2008-10-23
申请人: Richard J. Perner , John R. Koenig , Stanley DiDomenico, Jr. , Erol K. Bayburt , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Anil Vasudevan , Eric Voight
发明人: Richard J. Perner , John R. Koenig , Stanley DiDomenico, Jr. , Erol K. Bayburt , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Anil Vasudevan , Eric Voight
IPC分类号: A61K31/421 , C07D263/48
CPC分类号: C07D413/12 , C07D263/48 , C07D413/04
摘要: Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV 1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 在描述中定义R1,R2,R4和W的式(I)化合物是具有CNS穿透的TRPV 1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US20090124666A1
公开(公告)日:2009-05-14
申请号:US12256931
申请日:2008-10-23
申请人: Richard J. Perner , John R. Koenig , Stanley Didomenico, JR. , Erol K. Bayburt , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Anil Vasudevan , Eric Voight
发明人: Richard J. Perner , John R. Koenig , Stanley Didomenico, JR. , Erol K. Bayburt , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Anil Vasudevan , Eric Voight
IPC分类号: A61K31/4439 , C07D263/48 , C07D413/10 , A61P25/00 , A61K31/421
CPC分类号: C07D413/12 , C07D263/48 , C07D413/04
摘要: Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV 1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 在描述中定义R1,R2,R4和W的式(I)化合物是具有CNS穿透的TRPV 1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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7.
公开(公告)号:US08026256B2
公开(公告)日:2011-09-27
申请号:US11258980
申请日:2005-10-26
IPC分类号: C07D217/00 , A61K31/47
CPC分类号: C07D231/56 , C07D217/02 , C07D401/12 , C07D403/12
摘要: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
摘要翻译: 式(I)化合物是可用于治疗疼痛,炎性热痛觉过敏,尿失禁或膀胱过度活动的新型VR1拮抗剂。
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8.CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF 有权
标题翻译: 抑制VANILLOID受体亚型1(VR1)受体的氯霉素化合物及其用途公开(公告)号:US20110152250A1
公开(公告)日:2011-06-23
申请号:US12875839
申请日:2010-09-03
申请人: Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, JR. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
发明人: Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, JR. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
IPC分类号: A61K31/55 , C07D231/56 , A61K31/416 , C07D215/00 , A61K31/47 , C07D217/00 , C07D401/02 , A61K31/4709 , C07D403/02 , C07D413/02 , A61K31/5377 , A61P29/00 , A61P13/00 , A61P19/02
CPC分类号: C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
摘要: Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
摘要翻译: 作为VR1受体的拮抗剂的化合物,其具有式(I)或其前药的药学上可接受的盐,前药或盐,其中A1,A2,A3,A4,R7,R8,R9,X,Y,Z, L,n和m如本文所定义,并且可用于通过抑制VR1受体而防止或改善的病症。
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9.Tetrahydroquinolinyl compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof 有权
标题翻译: 抑制香草素受体亚型1(VR1)受体的四氢喹啉基化合物及其用途公开(公告)号:US08440691B2
公开(公告)日:2013-05-14
申请号:US12875839
申请日:2010-09-03
申请人: Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
发明人: Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
IPC分类号: A61K31/47 , A61K31/445 , A61K31/415 , C07D217/00 , C07D215/00 , C07D211/00 , C07D231/56
CPC分类号: C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
摘要: Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
摘要翻译: 作为VR1受体的拮抗剂的化合物,其具有式(I)或其前药的药学上可接受的盐,前药或盐,其中A1,A2,A3,A4,R7,R8,R9,X,Y,Z, L,n和m如本文所定义,并且可用于通过抑制VR1受体而防止或改善的病症。
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10.Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof 有权
标题翻译: 抑制香草素受体亚型1(VR1)受体的丝氨酸脲化合物及其用途公开(公告)号:US07812019B2
公开(公告)日:2010-10-12
申请号:US11285448
申请日:2005-11-22
申请人: Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
发明人: Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
IPC分类号: A61K31/5375 , A61K31/47 , A61K31/445 , A61K31/415 , A61K31/35 , C07D413/00 , C07D217/00 , C07D215/00 , C07D211/00 , C07D231/56 , C07D311/00
CPC分类号: C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
摘要: Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
摘要翻译: 作为VR1受体的拮抗剂的化合物,其具有式(I)或其前药的药学上可接受的盐,前药或盐,其中A1,A2,A3,A4,R7,R8,R9,X,Y,Z, L,n和m如本文所定义,并且可用于通过抑制VR1受体而防止或改善的病症。
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