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公开(公告)号：US20180369482A1
公开(公告)日：2018-12-27
申请号：US16060606
申请日：2016-12-29
申请人： Ascendis Pharma A/S
摘要： Disclosed is an auto injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge assembly comprising a cartridge (700) and a cartridge code (1000) feature, the cartridge containing the medicament; a code sensor configured to read the cartridge code feature; a drive module coupled to move a plunger rod; and a processing unit coupled to the code sensor and the drive module. The processing unit being configured to: receive from the code sensor a code signal indicative of the cartridge code feature; control the drive module to move the plunger rod to a first plunger rod position, the first plunger rod position being based on the code signal; receive a trigger event; control the drive module to move the plunger rod to a second plunger rod position following reception of the trigger event.
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公开(公告)号：US11684724B2
公开(公告)日：2023-06-27
申请号：US16607342
申请日：2018-05-23
申请人： Ascendis Pharma A/S
CPC分类号： A61M5/31576 , A61M5/19 , A61M5/20 , A61M2005/31588 , A61M2205/332 , A61M2205/3331 , A61M2205/3365 , A61M2205/50 , A61M2205/6072 , A61M2205/6081 , A61M2205/8206
摘要： Disclosed is a method and an auto-injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a resistance sensor configured to provide a resistance signal indicative of resistance against movement of the plunger rod; and a processing unit coupled to the drive module and to the resistance sensor. The processing unit being configured to: control the drive module to move the plunger rod towards the extended plunger rod position with a plunger rod speed; determine plunger rod position; receive the resistance signal; and control the drive module to adjust movement of the plunger rod if the resistance signal is indicative of resistance against movement of the plunger rod above a high resistance threshold, wherein the high resistance threshold is based on the plunger rod position.
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公开(公告)号：US11351305B2
公开(公告)日：2022-06-07
申请号：US16060600
申请日：2016-12-29
申请人： Ascendis Pharma A/S
摘要： Disclosed is an auto injector and a method for administering a medicament. The auto injector comprising: a housing; a cartridge receiver; a drive module coupled to move a plunger rod configured to move a first stopper; a temperature sensor configured to provide a temperature signal indicative of the temperature of the medicament in the cartridge; a processing unit configured to: receive the temperature signal; control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position wherein the movement from the first plunger rod position to the mix plunger rod position is based on the temperature signal.
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公开(公告)号：US11179524B2
公开(公告)日：2021-11-23
申请号：US16060593
申请日：2016-12-29
申请人： Ascendis Pharma A/S
摘要： Disclosed is an auto-injector for administering a medicament, comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper; a drive module coupled to move a plunger rod configured to move the first stopper; a resistance sensor configured to provide a resistance signal indicative of resistance against movement of the plunger rod; and a processing unit coupled to the drive module and to the resistance sensor. The processing unit being configured to: control the drive module to move the plunger rod towards the extended plunger rod position; determine present plunger rod position; receive the resistance signal; determine a cartridge parameter based on the resistance signal and the present plunger rod position; and control the drive module to adjust the movement of the plunger rod based on the cartridge parameter.
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公开(公告)号：US20180369481A1
公开(公告)日：2018-12-27
申请号：US16060600
申请日：2016-12-29
申请人： Ascendis Pharma A/S
摘要： Disclosed is an auto injector and a method for administering a medicament. The auto injector comprising: a housing; a cartridge receiver; a drive module coupled to move a plunger rod configured to move a first stopper; a temperature sensor configured to provide a temperature signal indicative of the temperature of the medicament in the cartridge; a processing unit configured to: receive the temperature signal; control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position wherein the movement from the first plunger rod position to the mix plunger rod position is based on the temperature signal.
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公开(公告)号：US11969581B2
公开(公告)日：2024-04-30
申请号：US17816360
申请日：2022-07-29
申请人： Ascendis Pharma A/S
CPC分类号： A61M5/3146 , A61M5/20 , A61M5/24 , A61M5/31511 , A61M2005/2411 , A61M2205/215 , A61M2205/3368 , A61M2205/6018 , A61M2205/6054 , A61M2205/6063 , A61M2205/6072
摘要： Disclosed is an auto injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge assembly comprising a cartridge and a cartridge code feature, the cartridge containing the medicament; a code sensor configured to read the cartridge code feature; a drive module coupled to move a plunger rod; and a processing unit coupled to the code sensor and the drive module. The processing unit being configured to: receive from the code sensor a code signal indicative of the cartridge code feature; control the drive module to move the plunger rod to a first plunger rod position, the first plunger rod position being based on the code signal; receive a trigger event; control the drive module to move the plunger rod to a second plunger rod position following reception of the trigger event.
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公开(公告)号：US20240082494A1
公开(公告)日：2024-03-14
申请号：US18514784
申请日：2023-11-20
申请人： Ascendis Pharma A/S
CPC分类号： A61M5/2448 , A61M5/20 , A61M5/3146 , A61M5/44 , A61M2205/50 , A61M2205/581 , A61M2205/583 , A61M2205/6063
摘要： Disclosed herein is an auto injector for administering a medicament, the auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper and a cartridge compartment containing the medicament, the cartridge compartment having a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a processing unit coupled to the drive module, wherein the processing unit is configured to control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position with a mix plunger rod speed, wherein the mix plunger rod position is selected to position the first stopper in a position wherein the first medicament component is mixed with the second medicament component, and to provide an onset signal after a number of completed inversions of the auto injector has been performed.
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公开(公告)号：US20230270945A1
公开(公告)日：2023-08-31
申请号：US18112265
申请日：2023-02-21
申请人： Ascendis Pharma A/S
CPC分类号： A61M5/2066 , A61M5/31511 , A61M5/20 , A61M5/24 , A61M5/31573 , A61M5/31576 , A61M5/326 , A61M2005/31588 , A61M2005/3267 , A61M2205/332 , A61M2205/3368 , A61M2205/502 , A61M2205/6063 , A61M2205/8206 , A61M2205/50 , A61M2205/82 , A61M2005/2411
摘要： Disclosed is a method for controlling an auto injector and an auto injector for administering a medicament from a cartridge having a first cartridge end and a second cartridge end and having a cartridge outlet at the first cartridge end, the cartridge comprising a cartridge compartment with a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament. The auto injector comprises: a housing; a cartridge receiver; a cartridge sensor; a drive module; an orientation sensor; and a processing unit.
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公开(公告)号：US20230263961A1
公开(公告)日：2023-08-24
申请号：US18309644
申请日：2023-04-28
申请人： Ascendis Pharma A/S
CPC分类号： A61M5/31576 , A61M5/19 , A61M5/20 , A61M2005/31588 , A61M2205/332 , A61M2205/3331 , A61M2205/3365 , A61M2205/50 , A61M2205/6072 , A61M2205/6081 , A61M2205/8206
摘要： Disclosed is a method and an auto-injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a resistance sensor configured to provide a resistance signal indicative of resistance against movement of the plunger rod; and a processing unit coupled to the drive module and to the resistance sensor. The processing unit being configured to: control the drive module to move the plunger rod towards the extended plunger rod position with a plunger rod speed; determine plunger rod position; receive the resistance signal; and control the drive module to adjust movement of the plunger rod if the resistance signal is indicative of resistance against movement of the plunger rod above a high resistance threshold, wherein the high resistance threshold is based on the plunger rod position.
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公开(公告)号：US20220265931A1
公开(公告)日：2022-08-25
申请号：US17741314
申请日：2022-05-10
申请人： Ascendis Pharma A/S
摘要： Disclosed is an auto injector and a method for administering a medicament. The auto injector comprising: a housing; a cartridge receiver; a drive module coupled to move a plunger rod configured to move a first stopper; a temperature sensor configured to provide a temperature signal indicative of the temperature of the medicament in the cartridge; a processing unit configured to: receive the temperature signal; control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position wherein the movement from the first plunger rod position to the mix plunger rod position is based on the temperature signal.
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