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公开(公告)号:US20150018334A1
公开(公告)日:2015-01-15
申请号:US14330307
申请日:2014-07-14
申请人: Asitha ABEYWARDANE , John BROADWATER , Steven Richard BRUNETTE , Thomas Martin KIRRANE, JR. , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Qiang ZHANG
发明人: Asitha ABEYWARDANE , John BROADWATER , Steven Richard BRUNETTE , Thomas Martin KIRRANE, JR. , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Qiang ZHANG
IPC分类号: C07D487/08 , A61K31/4439 , A61K31/496 , A61K31/551 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/4995 , C07D401/14 , A61K31/4709
CPC分类号: C07D487/08 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/4995 , A61K31/506 , A61K31/551 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要: The present invention relates to aryl pyrazoles, and pharmaceutically acceptable salts thereof. The aryl pyrazoles of the present invention are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the aryl pyrazoles of the present invention, methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译: 本发明涉及芳基吡唑及其药学上可接受的盐。 本发明的芳基吡唑可用作白三烯A4水解酶(LTA4H)的抑制剂和治疗LTA4H相关疾病。 本发明还涉及包含本发明的芳基吡唑的药物组合物,使用这些化合物治疗各种疾病和病症的方法,以及制备这些化合物的方法。
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公开(公告)号:US20140031339A1
公开(公告)日:2014-01-30
申请号:US13942988
申请日:2013-07-16
申请人: Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL
发明人: Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL
IPC分类号: C07D401/14 , C07D413/14 , C07D487/04 , C07D498/04 , C07D497/08 , A61K31/5377 , A61K31/55 , A61K31/549 , A61K31/496 , A61K31/4545 , A61K31/454 , C07D405/12 , A61K31/551
CPC分类号: C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04
摘要: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中A1,A2,L1和B如本文所定义。 式(I)化合物可用作白三烯A4水解酶(LTA4H)的抑制剂和治疗LTA4H相关疾病。 本发明还涉及包含式(I)化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,以及制备这些化合物的方法。
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公开(公告)号:US20130244996A1
公开(公告)日:2013-09-19
申请号:US13785034
申请日:2013-03-05
申请人: Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
发明人: Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
IPC分类号: C07D491/052 , C07D513/04 , C07D295/155 , C07D405/10 , C07D295/096
CPC分类号: C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译: 本发明涉及式(I)的化合物:其中R1至R3,A,X和n如本文所定义。 式(I)化合物可用作白三烯A4水解酶(LTA4H)的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式(I)化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,以及制备这些化合物的方法。
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公开(公告)号:US20130345195A1
公开(公告)日:2013-12-26
申请号:US13974879
申请日:2013-08-23
申请人: Asitha ABEYWARDANE , Michael J. BURKE , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Anil Kumar PADYANA , Lana Louise SMITH KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , QIANG ZHANG , Qing ZHANG
发明人: Asitha ABEYWARDANE , Michael J. BURKE , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Anil Kumar PADYANA , Lana Louise SMITH KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , QIANG ZHANG , Qing ZHANG
IPC分类号: C07D487/08 , C07D295/096 , C07D471/10 , C07D405/14 , C07D405/12 , C07D487/04 , C07D319/20 , C07D405/10 , C07D295/16
CPC分类号: C07D295/16 , A61K31/397 , A61K31/5377 , C07D295/096 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056
摘要: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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公开(公告)号:US20150018333A1
公开(公告)日:2015-01-15
申请号:US14330297
申请日:2014-07-14
IPC分类号: C07D401/14 , A61K31/4709 , A61K31/496
CPC分类号: C07D401/14 , A61K31/4709 , A61K31/496
摘要: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R 1在本文中定义。 式(I)化合物可用作白三烯A4水解酶(LTA4H)的抑制剂和治疗LTA4H相关疾病。 本发明还涉及包含式(I)化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,以及制备这些化合物的方法。
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公开(公告)号:US20100190773A1
公开(公告)日:2010-07-29
申请号:US12727570
申请日:2010-03-19
申请人: Asitha ABEYWARDANE , Craig Andrew MILLER , Tina Marie MORWICK , Neil MOSS , Matthew Russell NETHERTON , Roger John SNOW , Ji WANG , Jiang-Ping WU , Zhaoming XIONG
发明人: Asitha ABEYWARDANE , Craig Andrew MILLER , Tina Marie MORWICK , Neil MOSS , Matthew Russell NETHERTON , Roger John SNOW , Ji WANG , Jiang-Ping WU , Zhaoming XIONG
IPC分类号: A61K31/55 , C07D471/04 , A61K31/437 , C07D401/12 , A61K31/4439 , C07D487/04 , A61P3/10 , A61P1/00 , A61P19/02 , A61P25/28 , A61P9/04 , A61P11/06
CPC分类号: C07D471/02
摘要: Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
摘要翻译: 杂环化合物及其类似物及其作为丝裂原活化蛋白激酶活化蛋白激酶-2(MAPKAP-k2)的抑制剂的用途,以及用于预防或治疗疾病或病症的方法,所述方法可以通过调节 MAPKAP-K2在受试者中的活性以及包括这些MAPKAP-K2抑制剂的药物组合物和试剂盒。
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