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    OPTICAL DETECTOR
    5.
    发明申请
    OPTICAL DETECTOR 有权
    光学检测器

    公开(公告)号：US20100291667A1

    公开(公告)日：2010-11-18

    申请号：US12775044

    申请日：2010-05-06

    申请人： Yuji Segawa ,  Tasuku Yotoriyama ,  Shinichi Kai

    发明人： Yuji Segawa ,  Tasuku Yotoriyama ,  Shinichi Kai

    IPC分类号： C12Q1/68

    CPC分类号： G01N21/6454 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N21/6428 ,  G01N2201/068

    摘要： Disclosed herein is an optical detector at least including: a first substrate in which a plurality of wells are formed; a second substrate in which a heating section is provided to heat the wells; a third substrate in which a plurality of photoirradiation sections are provided in alignment with the wells; and a fourth substrate in which a plurality of photodetection sections are provided in alignment with the wells.

    摘要翻译： 本文公开了一种光学检测器，至少包括：第一基板，其中形成有多个孔; 第二基板，其中设置加热部分以加热所述孔; 第三基板，其中设置有与所述孔对准的多个光照射部分; 以及第四基板，其中设置有与所述孔对准的多个光电检测部。

    Real-time PCR system
    8.
    发明授权
    Real-time PCR system 有权
    实时PCR系统

    公开(公告)号：US08017380B2

    公开(公告)日：2011-09-13

    申请号：US12105722

    申请日：2008-04-18

    申请人： Toshiki Moriwaki ,  Tasuku Yotoriyama ,  Yuji Segawa

    发明人： Toshiki Moriwaki ,  Tasuku Yotoriyama ,  Yuji Segawa

    IPC分类号： C12Q1/68 ,  C12M1/36 ,  C12M1/38 ,  C12M3/00 ,  C12M1/34

    CPC分类号： G01K7/015 ,  B01J2219/00783 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/1827 ,  G01N21/6428

    摘要： A real-time PCR system for detecting gene expression levels includes plural reaction regions, a like plural number of heating portions arranged corresponding to the reaction regions and having heat sources, respectively, an optical unit capable of irradiating exciting light of a specific wavelength to all of the plural reaction regions, and a like plural number of fluorescence detecting portions arranged corresponding to the reaction regions, respectively. The heating portions are each provided with a temperature detector for detecting a temperature in a vicinity of the corresponding heat source and converting the temperature into an electrical signal and also with a controller for controlling a thermal dose from the corresponding heat source based on a correlation between electrical signals and calorific values of the heat source stored beforehand.

    摘要翻译： 用于检测基因表达水平的实时PCR系统包括多个反应区域，分别对应于反应区域排列并具有热源的多个加热部分，能够将特定波长的激发光全部照射到所有的光学单元 的多个反应区域，以及分别对应于反应区域排列的多个荧光检测部分。 加热部分每个设有温度检测器，用于检测相应热源附近的温度并将温度转换成电信号，并且还具有控制器，用于根据相应的热源之间的相关性控制热剂量 预先存储的热源的电信号和发热量。

    Hybridization detecting unit relying on dielectrophoresis and sensor chip provided with the detecting unit
    9.
    发明授权
    Hybridization detecting unit relying on dielectrophoresis and sensor chip provided with the detecting unit 失效
    杂交检测单元依赖于介电电泳和设有检测单元的传感器芯片

    公开(公告)号：US07709195B2

    公开(公告)日：2010-05-04

    申请号：US11221940

    申请日：2005-09-09

    申请人： Yuji Segawa ,  Noriyuki Kishii

    发明人： Yuji Segawa ,  Noriyuki Kishii

    IPC分类号： C12Q1/68 ,  C12N11/16 ,  G01N15/06 ,  C07H21/04

    CPC分类号： B03C5/026 ,  B03C5/005 ,  B03C2201/24 ,  B03C2201/26

    摘要： A hybridization detecting unit which includes a reaction region in which hybridization takes place, a plurality of sites (e.g., the surface of electrodes) arranged in the reaction region to which is fixed a nucleic acid for detection, and means for sequentially moving by dielectrophoresis the target nucleic acid introduced into the reaction region according to the order of arrangement of the sites to which is fixed a nucleic acid for detection. A sensor chip provided with the hybridization detecting unit. The detecting unit compulsorily moves the target nucleic acid into the region where a probe nucleic acid for detection exists, thereby increasing the probability of hybridization taking place.

    摘要翻译： 杂交检测单元，其包括发生杂交的反应区域，配置在固定有用于检测的核酸的反应区域中的多个位点（例如，电极表面），以及通过介电电泳依次移动的装置 根据固定用于检测的核酸的位点的排列顺序将目标核酸引入反应区域。 设置有杂交检测单元的传感器芯片。 检测单元强制地将目标核酸移动到存在检测用探针核酸的区域，从而增加发生杂交的可能性。

    Method of producing metallic film
    10.
    发明授权
    Method of producing metallic film 失效
    金属膜的制造方法

    公开(公告)号：US06911396B2

    公开(公告)日：2005-06-28

    申请号：US10469580

    申请日：2002-12-27

    申请人： Shuzo Sato ,  Takeshi Nogami ,  Yuji Segawa

    发明人： Shuzo Sato ,  Takeshi Nogami ,  Yuji Segawa

    IPC分类号： C25D5/48 ,  C25D7/12 ,  C25F3/22 ,  H01L21/28 ,  H01L21/288 ,  H01L21/3205 ,  H01L21/768 ,  H01L23/52 ,  H01L21/311 ,  H01L21/20 ,  H01L21/461

    CPC分类号： H01L21/76877 ,  C25D5/48 ,  C25D7/12 ,  C25F3/22 ,  H01L21/2885 ,  H01L21/7684

    摘要： Concentration of electric current due to an additive (particularly, a brightener) remaining or precipitated in a high concentration at grain boundary triple points and wiring groove portions in the surface layer of a copper plating film is obviated, whereby precedent dissolution and/or abnormal dissolution due to concentration of electric current is restrained, and an electropolished surface of the copper plating film with excellent surface smoothness is obtained.A method of producing a metallic film includes the steps of: forming a metallic plating film (copper plating film (15)) by use of a plating solution prepared by adding a plating additive for restraining void generation, bottom-up fill and overfill; and electropolishing the metallic plating film by use of an electropolishing solution prepared by adding a polishing additive capable of reacting or coupling with the plating additive component contained or precipitated in the surface layer of the metallic plating film.

    摘要翻译： 避免了由于在镀铜膜的表面层中的晶界三点和布线槽部分处高浓度地残留或沉淀的添加剂（特别是增白剂）导致的电流浓度，从而导致先前的溶解和/或异常溶解 由于电流的集中受到抑制，并且获得了具有优异表面平滑度的镀铜膜的电抛光表面。 制造金属膜的方法包括以下步骤：通过使用通过添加用于抑制空洞产生的电镀添加剂，自底向上填充和填充填充而制备的电镀液，形成金属镀膜（镀铜膜（15））。 并使用通过添加能够与包含或沉淀在金属镀膜的表面层中的镀覆添加剂成分反应或偶合的抛光添加剂而制备的电解抛光溶液电抛光金属镀膜。