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    Carotid physiological parameter monitoring system
    1.
    发明授权
    Carotid physiological parameter monitoring system 有权

    公开(公告)号：US11375911B2

    公开(公告)日：2022-07-05

    申请号：US16630355

    申请日：2018-07-10

    申请人： Shiming Lin ,  BIV MEDICAL, LTD.

    发明人： Shiming Lin

    IPC分类号： A61B5/0245 ,  A61B5/021 ,  A61B5/024 ,  A61B5/00 ,  A61B5/0507 ,  A61B8/04 ,  A61B5/02 ,  A61B7/04

    摘要： The present invention provides a carotid physiological parameter monitoring system, comprising: an electrocardiographic (ECG) monitoring device, a carotid pulse wave detector, and at least one controller. The ECG monitoring device is disposed on a user's left and right wrists or on the user's chest to obtain ECG waveforms. The carotid pulse wave detector is disposed on the user's neck at a position corresponding to the user's carotid arteries for obtaining carotid pulse waveforms. The controller is provided in at least one of the ECG monitoring device, the carotid pulse wave detector, and a mobile device, wherein the controller is configured to obtain the user's carotid physiological parameter(s) (which may include carotid pulse wave velocity or carotid blood pressure) by calculating with the ECG waveforms and/or the carotid pulse waveforms.

    Single-arm micro air-pressure pump device
    3.
    发明授权
    Single-arm micro air-pressure pump device 有权

    公开(公告)号：US11517208B2

    公开(公告)日：2022-12-06

    申请号：US16465498

    申请日：2017-11-29

    申请人： Shiming Lin ,  BIV MEDICAL, LTD.

    发明人： Shiming Lin

    IPC分类号： A61B5/021 ,  A61B5/022 ,  A61B5/00 ,  A61B5/0225 ,  F04B43/02 ,  F04B53/10 ,  A61B5/361 ,  F04B45/047 ,  A61B5/0235

    摘要： A single-arm micro air-pressure pump device, having an air pump body and a driving unit. The air pump body includes a supporting frame, an air chamber unit coupled to a side of the supporting frame, and a swing arm provided on the air chamber unit. The driving unit is fixed on the supporting frame and has an output shaft. The output shaft is provided with an eccentric shaft and is configured to rotate the eccentric shaft, and the eccentric shaft has an end coupled to the output shaft and an opposite end coupled to the swing arm in order to drive the swing arm into a reciprocating motion between at least a proximal position and a distal position with respect to the air chamber unit. The reciprocating motion pushes a piston unit provided on one end of the swing arm and causes the air output.

    ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES
    6.
    发明申请
    ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES 审中-公开
    具有电导率促销分子的静电抗体检测和测量传感器

    公开(公告)号：US20100172800A1

    公开(公告)日：2010-07-08

    申请号：US12652419

    申请日：2010-01-05

    申请人： Shiming Lin ,  Shih-Yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

    发明人： Shiming Lin ,  Shih-Yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

    IPC分类号： G01N30/00

    CPC分类号： G01N33/5438

    摘要： A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, a layer of antibody immobilized on the surface of at least one of said electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules are conjugated with the antibody to improve electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.

    摘要翻译： 公开了一种用于在测试样品中电敏感抗原的传感器。 该传感器具有彼此电隔离并物理分离的两个电极，一层抗体固定在至少一个所述电极的表面上。 抗体与抗原具有特异性结合活性。 电导率促进分子与抗体缀合以改善两个电极之间的导电特性。 抗体捕获与在与抗体填充的电极接触的缓冲溶液中混合的测试样品中存在的抗原。 这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

    Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon Resonance (SPR)
    7.
    发明申请
    Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon Resonance (SPR) 有权
    利用表面等离振子共振（SPR）的横向传播波的生物分子传感器系统

    公开(公告)号：US20060170925A1

    公开(公告)日：2006-08-03

    申请号：US11049085

    申请日：2005-02-02

    申请人： Chii-Wann Lin ,  Chih Kung Lee ,  Zhi-Hsiang Sung ,  Shiming Lin

    发明人： Chii-Wann Lin ,  Chih Kung Lee ,  Zhi-Hsiang Sung ,  Shiming Lin

    IPC分类号： G01N21/55

    CPC分类号： G01N21/553

    摘要： A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.

    摘要翻译： 描述了利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统。 该系统包括：基板; 介电层，其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置，每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。 此外，传感器系统还包括光源，光检测器（其前端连接到光谱仪和连接到差分放大器的后端）以及形成在凹槽内的盖的通道，用于获取反射光的反射光 棱镜装置。 由于传感器系统是通过利用SPR技术在横向传播中构建的，因此整个接触面被检测（并行检测），与传统的单区域SPR检测方法相区分。 传感器系统不仅适用于横向距离为几厘米的远红外遥感，而且适用于微型尺寸和高通量的生物医学传感应用。

    Biosensor
    9.
    发明授权
    Biosensor 有权
    生物传感器

    公开(公告)号：US08877022B2

    公开(公告)日：2014-11-04

    申请号：US13165464

    申请日：2011-06-21

    申请人： Shiming Lin ,  Bor-Ching Sheu ,  Luan-Yin Chang ,  Chih-Chen Lin

    发明人： Shiming Lin ,  Bor-Ching Sheu ,  Luan-Yin Chang ,  Chih-Chen Lin

    IPC分类号： G01N27/327 ,  G01N33/543

    CPC分类号： G01N33/5438 ,  G01N27/3276

    摘要： Embodiments of the present disclosure set forth a biosensor for detecting a target. One example sensor includes a first electrode. The first electrode includes a first electron conducting molecule and a first probe. The first probe includes a second electron conducting molecule. The first probe is configured to bind to the target of interest in solution. The first and second electron conducting molecules are different.

    摘要翻译： 本公开的实施例提出了用于检测目标的生物传感器。 一个示例性传感器包括第一电极。 第一电极包括第一电子传导分子和第一探针。 第一探针包括第二电子传导分子。 第一个探针被配置为绑定到解决方案中的感兴趣的目标。 第一和第二电子传导分子是不同的。

    Apparatus With Temperature Self-Compensation And Method Thereof
    10.
    发明申请
    Apparatus With Temperature Self-Compensation And Method Thereof 有权
    带温度自补偿装置及其方法

    公开(公告)号：US20110158288A1

    公开(公告)日：2011-06-30

    申请号：US12789289

    申请日：2010-05-27

    申请人： Long-Sun Huang ,  Yu-Fu Ku ,  Yi-Kuang Yen ,  Shu Kuan ,  Kuang-Chong Wu ,  Shiming Lin ,  Ping-Yen Lin

    发明人： Long-Sun Huang ,  Yu-Fu Ku ,  Yi-Kuang Yen ,  Shu Kuan ,  Kuang-Chong Wu ,  Shiming Lin ,  Ping-Yen Lin

    IPC分类号： G01K7/16

    CPC分类号： G01N29/022

    摘要： A system for compensating a thermal effect is provided and includes a substrate structure and a microcantilever. The substrate structure includes a first piezoresistor. The first piezoresistor is buried in the substrate structure and has a first piezoresistance having a first relation to a first variable temperature. The microcantilever has the thermal effect and a second piezoresistance having a second relation to the first variable temperature, wherein the thermal effect is compensated based on the first and the second relations.

    摘要翻译： 提供了用于补偿热效应的系统，并且包括衬底结构和微悬臂梁。 衬底结构包括第一压电电阻器。 第一压电电阻器被埋在衬底结构中，并且具有与第一可变温度具有第一关系的第一压电阻。 微悬臂梁具有热效应和与第一可变温度具有第二关系的第二压阻，其中基于第一和第二关系补偿热效应。