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公开(公告)号:US20190382410A1
公开(公告)日:2019-12-19
申请号:US16527773
申请日:2019-07-31
IPC分类号: C07D487/04
摘要: This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.
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公开(公告)号:US10196436B2
公开(公告)日:2019-02-05
申请号:US15867637
申请日:2018-01-10
IPC分类号: C07D239/78 , C07K14/71 , A61K31/4375 , C07D401/04 , A61K31/519 , A61K31/517 , C07D475/04 , C07D471/04 , C07D295/155 , C07D239/84 , C07D487/04 , C07D475/00 , C07D239/42
摘要: Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
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公开(公告)号:US10000490B2
公开(公告)日:2018-06-19
申请号:US15599006
申请日:2017-05-18
IPC分类号: C07D487/04 , C07D471/04 , C07D403/04 , A61K31/517 , A61P35/00 , C07D413/04 , C07D239/74 , C07D217/16 , C07D217/14 , C07D487/14
CPC分类号: C07D471/04 , A61K31/517 , C07D217/14 , C07D217/16 , C07D239/74 , C07D403/04 , C07D413/04 , C07D487/04 , C07D487/14
摘要: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of FGFR-4.
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公开(公告)号:US20170066812A1
公开(公告)日:2017-03-09
申请号:US15097995
申请日:2016-04-13
发明人: Neil Bifulco, JR. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
IPC分类号: C07K14/71 , C07D401/04 , C07D475/04 , C07D239/42 , C07D239/84 , C07D471/04
CPC分类号: C07K14/71 , A61K31/4375 , A61K31/517 , A61K31/519 , C07D239/42 , C07D239/84 , C07D295/155 , C07D401/04 , C07D471/04 , C07D475/00 , C07D475/04 , C07D487/04
摘要: Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
摘要翻译: 本文描述的是FGFR的抑制剂,包括这些化合物的药物组合物,以及使用这些化合物和组合物抑制酪氨酸激酶活性的方法。
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公开(公告)号:US20230112729A1
公开(公告)日:2023-04-13
申请号:US17864106
申请日:2022-07-13
发明人: Jason D. Brubaker , Joshua T. Close , Thomas A. Dineen , Chandrasekhar V. Miduturu , Emanuele Perola
IPC分类号: C07D519/00 , A61P35/00 , C07D491/052
摘要: One embodiment of the disclosure is a compound represented by Formula I or a pharmaceutically acceptable salt thereof. The variables in Formula I are defined herein. Compounds of Formula I are MAP4K1 inhibitors, which can be used to treat a diseases or disorders in a subject that benefits from control of MAP4K1 activity.
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公开(公告)号:US10221154B2
公开(公告)日:2019-03-05
申请号:US15222523
申请日:2016-07-28
IPC分类号: C07D405/12 , C07D409/12 , A61K31/517 , C07D401/04 , C07D239/84 , C07D403/12 , C07D471/04 , C07D475/00 , C07D401/12 , C07D235/30 , C07D403/14
摘要: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号:US10370379B2
公开(公告)日:2019-08-06
申请号:US15355425
申请日:2016-11-18
IPC分类号: C07D487/04 , A61K31/519 , A61P35/00
摘要: This disclosure relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants, such as compounds of Formula I:
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公开(公告)号:US09884861B2
公开(公告)日:2018-02-06
申请号:US15093354
申请日:2016-04-07
IPC分类号: C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/53 , A61K31/5377 , A61K31/5415 , A61K31/635 , A61K31/675 , A61P35/00 , A61K31/55 , A61K31/553 , A61K45/06 , C07D403/12 , C07D405/14 , C07F9/6521 , C07D251/18 , C07F9/6558
CPC分类号: C07D471/04 , A61K31/53 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/553 , A61K31/635 , A61K31/675 , A61K45/06 , C07D251/18 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/6521 , C07F9/65583
摘要: Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.
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公开(公告)号:US20170174652A1
公开(公告)日:2017-06-22
申请号:US15222523
申请日:2016-07-28
IPC分类号: C07D401/04 , C07D405/12 , C07D403/12 , C07D403/14 , C07D401/12 , C07D409/12 , C07D475/00 , C07D239/84 , C07D471/04
CPC分类号: C07D401/04 , C07D235/30 , C07D239/84 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D471/04 , C07D475/00
摘要: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号:US20170145018A1
公开(公告)日:2017-05-25
申请号:US15355425
申请日:2016-11-18
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.
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