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公开(公告)号:US10000496B2
公开(公告)日:2018-06-19
申请号:US15217503
申请日:2016-07-22
发明人: Brian L. Hodous , Kevin J. Wilson , Yulian Zhang
IPC分类号: C07D487/04 , A61K31/53 , A61K45/06
CPC分类号: C07D487/04 , A61K31/53 , A61K45/06
摘要: Compounds and compositions useful for treating disorders related to KIT and PDGFR are described herein.
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公开(公告)号:US09994575B2
公开(公告)日:2018-06-12
申请号:US14887614
申请日:2015-10-20
IPC分类号: C07D487/04 , C07D403/14 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/53 , A61K31/5377 , A61K31/496 , A61P35/00 , A61K45/06
CPC分类号: C07D487/04 , A61K31/496 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要: Compounds and compositions useful for treating disorders related to mutant KIT are described herein.
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公开(公告)号:US09884861B2
公开(公告)日:2018-02-06
申请号:US15093354
申请日:2016-04-07
IPC分类号: C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/53 , A61K31/5377 , A61K31/5415 , A61K31/635 , A61K31/675 , A61P35/00 , A61K31/55 , A61K31/553 , A61K45/06 , C07D403/12 , C07D405/14 , C07F9/6521 , C07D251/18 , C07F9/6558
CPC分类号: C07D471/04 , A61K31/53 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/553 , A61K31/635 , A61K31/675 , A61K45/06 , C07D251/18 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/6521 , C07F9/65583
摘要: Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.
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公开(公告)号:US20170204104A1
公开(公告)日:2017-07-20
申请号:US15479145
申请日:2017-04-04
IPC分类号: C07D487/04
CPC分类号: C07D487/04 , A61K31/496 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要: Compounds and compositions useful for treating disorders related to mutant KIT are described herein.
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公开(公告)号:US20170029409A1
公开(公告)日:2017-02-02
申请号:US15295450
申请日:2016-10-17
发明人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
IPC分类号: C07D403/14 , C07D487/04 , C07D413/14 , C07D409/14 , C07D487/08 , C07D405/14 , C07D473/34 , C07D401/14
CPC分类号: C07D403/14 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D487/04 , C07D487/08 , C07D487/22
摘要: Compounds and compositions useful for treating disorders related to Kit are described herein.
摘要翻译: 本文描述了可用于治疗与Kit相关的疾病的化合物和组合物。
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公开(公告)号:US20230129944A1
公开(公告)日:2023-04-27
申请号:US17983747
申请日:2022-11-09
IPC分类号: C07D487/04 , C07D401/14 , C07D413/14 , C07D403/14 , C07D417/14 , C07D403/04 , A61K31/53 , A61K31/5377 , A61K45/06 , A61K31/496
摘要: Compounds and compositions useful for treating disorders related to mutant KIT are described herein.
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公开(公告)号:US10227329B2
公开(公告)日:2019-03-12
申请号:US15657057
申请日:2017-07-21
发明人: Jason D. Brubaker , Timothy Guzi , Kevin J. Wilson , Lucian V. Dipietro , Yulian Zhang , Douglas Wilson , Paul E. Fleming
IPC分类号: C07D401/14
摘要: Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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公开(公告)号:US10202365B2
公开(公告)日:2019-02-12
申请号:US15548925
申请日:2016-02-05
发明人: Natasja Brooijmans , Lucian V. DiPietro , Paul E. Fleming , Joseph L. Kim , Steven Mark Wenglowsky , Yulian Zhang
IPC分类号: A61K31/506 , C07D401/14 , C07D403/12 , C07D405/14 , C07D403/04 , C07D417/14 , A61K45/06
摘要: Described herein are compounds, such as compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions, e.g., for treating a condition mediated by aberrant RET activity
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9.COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT AND PDFGR 有权
标题翻译: 用于治疗与工具包和PDFGR相关的疾病的组合物公开(公告)号:US20170022206A1
公开(公告)日:2017-01-26
申请号:US15217503
申请日:2016-07-22
发明人: Brian L. Hodous , Kevin J. Wilson , Yulian Zhang
IPC分类号: C07D487/04 , A61K45/06 , A61K31/53
CPC分类号: C07D487/04 , A61K31/53 , A61K45/06
摘要: Compounds and compositions useful for treating disorders related to KIT and PDGFR are described herein.
摘要翻译: 本文描述了可用于治疗与KIT和PDGFR相关的疾病的化合物和组合物。
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公开(公告)号:US20190119280A1
公开(公告)日:2019-04-25
申请号:US15973340
申请日:2018-05-07
发明人: Brian L. HODOUS , Kevin J. Wilson , Yulian Zhang
IPC分类号: C07D487/04 , A61K31/53 , A61K45/06
摘要: Compounds and compositions useful for treating disorders related to KIT and PDGFR are described herein.
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