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公开(公告)号：US3853466A
公开(公告)日：1974-12-10
申请号：US26292372
申请日：1972-06-14
发明人： RITTERSDORF W , RIECKMANN P , BERGER D , REY H
CPC分类号： G01N33/72 , Y10S436/903 , Y10T436/146666
摘要： Diagnostic agent for the detection of urobilinogens, optionally in the presence of bilirubin, in body fluids which agent comprises at least one stable benzene diazonium salt wherein the phenyl radical may be polysubstituted and contains in the o- or p-position at least one polyatomic electron donor group with at least one mesomeric electron pair, the sum of the Hammett sigma values for all the substituents not exceeding the value of +0.4.
摘要翻译： 用于在体液中检测泌尿生素（任选在胆红素存在下）的诊断剂，其中所述药物包含至少一种稳定的苯重氮盐，其中所述苯基可以是多取代的，并且在至少一个多原子电子 具有至少一个中间电子对的给体基团，所有取代基的哈米特σ值的总和不超过+0.4。
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公开(公告)号：US3853476A
公开(公告)日：1974-12-10
申请号：US38224273
申请日：1973-07-24
发明人： RITTERSDORF W , REY H , RIECKMANN P , GUTHLEIN W , BERGER D
CPC分类号： G01N33/728 , Y10S436/903 , Y10T436/146666
摘要： WHEREIN R1 and R2 are individually selected from unsubstituted or substituted aliphatic, cycloaliphatic araliphatic or aromatic radicals, and contain not more than 18 carbon atoms each.
Bilirubin, particularly as contained in body fluids, is detected by contacting a test sample with a test composition comprising A. A DIAZONIUM SALT CAPABLE OF COUPLING WITH BILIRUBIN; B. AN ACID IN AN AMOUNT SUFFICIENT FOR THE COUPLING REACTION BETWEEN SAID SALT AND BILIRUBIN AND; C. A PHOSPHORIC ACID DIESTER OF THE FORMULA:摘要翻译： 通过使测试样品与包含A的测试组合物接触来检测体液中特别包含的胆红素。可与二氯联苯结合的二氮嗪盐; B.对于盐酸和胆红素之间的联合反应的量足够大; C.公式的磷酸乳剂：
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公开(公告)号：US3850576A
公开(公告)日：1974-11-26
申请号：US31406772
申请日：1972-12-11
发明人： RIECKMANN P , RITTERSDORF W , BERGER D , REY H
CPC分类号： G01N33/72 , Y10S436/903 , Y10T436/146666
摘要： Urobilinogens, optionally in the presence of bilirubin, are detected with a novel diagnostic agent comprising A. AT LEAST ONE STABLE DIAZONIUM SALT CONTAINING A PHENYL-, PYRROLE, OR PYRAZOLE RING ANNELLATED WITH AN AROMATIC SYSTEM IN A MESOMERIZABLE AND STERICALLY UNHINDERED POSITION OR SUBSTITUTED DIRECTLY OR VIA A VINYLENE RADICAL WITH AN AROMATIC SYSTEM, OR B. A PYRIDINE OR PYRAZOLE DIAZONIUM SALT SUBSTITUTED IN A MESOMERIZABLE POSITION WITH AT LEAST ONE POLYATOMIC ELECTRON DONOR GROUP HAVING AT LEAST ONE MESOMERIZABLE ELECTRON PAIR WITH THE PROVISO THAT THE SUM OF THE Hammett sigma values for all the substituents, and hetero atoms does not exceed the value of +0.6.
摘要翻译： 任选地在胆红素存在下，用包含A的新型诊断剂检测无脊椎动物细胞。在具有可置换和无规定位置或直接取代的芳香系统中的至少一种稳定的二苯并三唑盐包含苯基，吡咯或吡唑环。 或通过具有芳族体系的乙烯基离子，或B.在具有至少一个可聚合电子对的至少一个可聚合电子对的可可位置中取代的吡啶或吡唑二盐，其具有Hammett sigma值的值 对于所有取代基，杂原子不超过+0.6的值。
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