公开(公告)号：US3928349A

公开(公告)日：1975-12-23

申请号：US33609973

申请日：1973-02-26

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BERGER HERBERT ,  GALL RUDI ,  STACH KURT ,  VOMEL WOLFGANG ,  HOFFMANN RITA

IPC分类号： A61K31/50 ,  A61P31/04 ,  C07D403/04 ,  C07D487/04 ,  C07D237/00

CPC分类号： C07D487/04

摘要： Nitroimidazolyl-s-triazolo(4,3-b)pyridazines of the formula:
wherein R1 and R2 are, individually, hydrogen or a numbe organic radicals or, taken together, can be an alkylene bridge; AND R3 is hydrogen or lower alkyl; or, together with R2, R3 can form an alkylene bridge; N IS 0 OR 1; AND THE PHARMACEUTICALLY COMPATIBLE THEREOF, POSSESS HIGH IN VIVO EFFECTIVENESS AS ANTIMICROBIALS.

WHEREIN R is hydrogen or lower alkyl optionally substituted in the 2position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula:

摘要翻译： 具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪