公开(公告)号：US3880588A

公开(公告)日：1975-04-29

申请号：US38224173

申请日：1973-07-24

申请人： BOEHRINGER MANNHEIM GMBH

发明人： RITTERSDORF WALTER ,  GUTHLEIN WERNER ,  BERGER DIETER ,  REY HANS-GEORG ,  RIECKMANN PETER

IPC分类号： G01N33/72 ,  G01N31/22 ,  G01N33/16

CPC分类号： G01N33/728 ,  Y10S436/903 ,  Y10T436/146666

摘要： WHEREIN X is a stabilizing anion; R1 and R2, which may be the same or different, are halogen or lower alkyl or alkoxy and R3 and R4, which may be the same or different, are hydrogen, halogen, nitro, or lower alkyl or alkoxy; THE AROMATIC RING IN FORMULA (I) containing either (a) 1 to 3 halogen atoms or (b) one nitro group, but not both together; and an amount of an acid sufficient for a coupling reaction between bilirubin and said diazonium salt.

Bilirubin, particularly as contained in body fluids, is determined with test strips comprising an absorbent

摘要翻译： 特别是包含在体液中的胆红素由包含吸收剂的测试条确定，其中X是稳定的阴离子; R 1和R 2可以相同或不同，为卤素或低级烷基或烷氧基，R 3和R 4可以相同或不同，为氢，卤素，硝基或低级烷基或烷氧基; 式（I）中的芳族环（I）含有（a）1至3个卤素原子或（b）一个硝基，但不包括在一起; 以及一定量的足以用于胆红素与所述重氮盐之间的偶联反应的酸。

公开(公告)号：US3630957A

公开(公告)日：1971-12-28

申请号：US3630957D

申请日：1967-11-15

申请人： BOEHRINGER MANNHEIM GMBH

发明人： REY HANS-GEORG ,  RIECKMANN PIETER ,  WIELINGER HANS ,  RITTERSDORF WALTER

IPC分类号： C12Q1/00 ,  C12Q1/28 ,  C12Q1/54 ,  G01N33/52 ,  G01N31/22 ,  G01N33/16

CPC分类号： G01N33/521 ,  C12Q1/00 ,  C12Q1/28 ,  C12Q1/54 ,  Y10S435/805 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/171538 ,  Y10T436/173076

摘要： DIAGNOSTIC AGENTS FOR USE IN THE DETECTION OF BIOCHEMICAL AND CHEMICAL COMPONENTS IN BLOOD, URINE AND OTHER BIOLOGICAL FLUIDS ARE DISCLOSED COMPRISING WATER-RESISTANT FILMS IN WHICH A COMPOSITION FORMING COLOR IN RESPONSE TO SAID CHEMICAL OR BIOLOGICAL COMPONET IS UNIFORMLY DISTRIBUTED.

公开(公告)号：US3917452A

公开(公告)日：1975-11-04

申请号：US52666174

申请日：1974-11-25

申请人： BOEHRINGER MANNHEIM GMBH

发明人： RITTERSDORF WALTER ,  GUTHLEIN WERNER ,  REY HANS-GEORG ,  RIECKMANN PETER

IPC分类号： G01N33/50 ,  C12Q1/00 ,  C12Q1/28 ,  C07D213/24 ,  G01N31/22 ,  G01N33/16

CPC分类号： C12Q1/28 ,  C12Q2326/00 ,  Y10S435/805 ,  Y10S436/904

摘要： Test strips for the detection of peroxidatively active substances in body fluids, e.g., for the detection of blood in urine, comprising a carrier containing A. A HYDROPEROXIDE; B. AT LEAST ONE CHROMOGEN; AND C. AS AN ACTIVATOR A COMPOUND OF THE FORMULA:

WHEREIN R1 is pyridyl or phenyl, optionally substituted by lower alkyl or alkoxy, and R2 is hydrogen or lower alkyl.

摘要翻译： 用于检测体液中的过氧化活性物质的测试条，例如用于检测尿液中的血液，包括含有A.A.氢过氧化物的载体; B.最少一个色素; 和C.作为激活剂公式的化合物：

公开(公告)号：US3630680A

公开(公告)日：1971-12-28

申请号：US3630680D

申请日：1968-10-18

申请人： BOEHRINGER MANNHEIM GMBH

发明人： RITTERSDORF WALTER ,  RIECKMANN PETER

IPC分类号： G01N33/72 ,  G01N21/06 ,  G01N31/22 ,  G01N33/16

CPC分类号： G01N33/72 ,  Y10T436/146666

摘要： Diagnostic agents for use in the detection of urobilinogen materials in body fluids such as urine, the agents comprising at least one strong acid and at least one compound which reacts with urobilinogen materials present in the body fluids to provide analytically measurable dyestuffs wherein said compound has the formula:

IN WHICH R1 and R2 which may be the same or different, each represent halogen, cyano, nitroso, carbalkoxy, carbamido, hydroxy, acyloxy, alkoxy, straight-chained and cyclic, saturated and unsaturated secondary and tertiary amino, or R1 and R2 together represent oxygen, sulfur, sulfonyl, alkylthionium, imino, alkylimino, substituted or unsubstituted arylimino or open-chained, alicyclic or heterocyclic dialkylimino, R2 can also represent the residue of secondary straight or branched, openchained or mono- or polycyclic alkyl or aralkyl and wherein one of R1 and R2 can also represent hydrogen, R3 is hydrogen or alkyl, and n and m which may be the same or different each have a value of 0, 1, 2 or 3.

公开(公告)号：US3902847A

公开(公告)日：1975-09-02

申请号：US34958373

申请日：1973-04-09

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BUSCH ERNST-WERNER ,  LANGE HANS ,  REY HANS-GEORG ,  RITTERSDORF WALTER

IPC分类号： G01N33/52 ,  G01N33/68 ,  G01N33/16 ,  G01N21/06 ,  G01N31/08

CPC分类号： G01N33/526 ,  G01N33/6839

摘要： Mucoviscidosis (cystic fibrosis) is detected in its early stages, particularly in the large-scale screening in newborn infants, by means of measuring the pathologically elevated protein content in the meconium, using a diagnostic agent comprising a protein test strip sealed to a longer plastic strip, applying meconium to the (flush) bottom portion of the combined strip, immersing the smeared portion of the strip in water, permitting water to wet the strip by ascending chromatography, and reading a color change in the strip as an indication of elevated protein content in the meconium.

摘要翻译： 通过使用包含密封到较长塑料的蛋白质测试条的诊断试剂，通过测量胎粪中的病理学升高的蛋白质含量，在其早期阶段检测到粘液性软骨病（囊性纤维化），特别是在新生儿的大规模筛查中 将胎粪施加到组合条的（冲洗）底部，将条带的涂抹部分浸入水中，允许水通过上升色谱法润湿条带，并读取条带中的颜色变化作为升高的蛋白质的指示 胎粪中的含量

公开(公告)号：US3897214A

公开(公告)日：1975-07-29

申请号：US30612772

申请日：1972-11-13

申请人： BOEHRINGER MANNHEIM GMBH

发明人： LANGE HANS ,  RITTERSDORF WALTER ,  REY HANS-GEORG

IPC分类号： G01N33/50 ,  G01N33/52 ,  G01N33/64 ,  G01N29/02 ,  G01N31/22 ,  G01N33/16

CPC分类号： G01N33/521 ,  Y10S435/805 ,  Y10T436/146666 ,  Y10T436/200833

摘要： Diagnostic agent for the detection of components contained in liquids, e.g. body fluids, comprising a felt or fleece of preponderantly polyamide fibers and impregnated with appropriate reagents.

摘要翻译： 用于检测液体中包含的组分的诊断剂，例如 体液，包含主要聚酰胺纤维的毡或羊毛，并用适当的试剂浸渍。