摘要:
2-Alkyl-4(3H)-pteridinone compounds of the formula
WHEREIN R is a straight-chain, branched or cyclic alkyl radical containing two to seven carbon atoms; AND THE SALTS THEREOF WITH PHYSIOLOGICALLY COMPATIBLE ACIDS AND BASES; ARE OUTSTANDINGLY EFFECTIVE IN DIURETIC AND NATRIURETIC ACTION.
WHEREIN R1 IS HYDROGEN ATOM OR A LOWER ALKYL; R2 IS LOWER ALKYL; R3 IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS, WHEN PRESENT, BEING HALOGEN OR LOWER ALKYL OR ALKOXY GROUPS, AND N IS 1, 2 OR 3, AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; HAVE OUTSTANDING ANTI-OEDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.
摘要:
Novel 5-phenyl-tetrazole derivatives of the general formula:
WHEREIN X is a halogen atom, an azido group or a trifluoromethyl radical, R1 is a hydrogen atom or a lower alkyl radical, R2 is a phenyl, furyl or thienyl radical and n is 0, 1 or 2; and the pharmacologically compatible salts thereof, possess exceptional diuretic and saluretic properties.
摘要:
Novel substituted cyclophosphate compounds of the formula:
WHEREIN X is halogen, hydrocarbyl, sulfhydryl, thioether, alkylsulfoxy, alkylsulfonyl or hydrocarbyl-substituted amino wherein said hydrocarbyl and alkyl radicals contain up to about 12 carbon atoms, and R3 is hydrogen or hydroxyl; ARE PREPARED BY REACTING THE CORRESPONDING AMINE COMPOUND (WHEREIN X in the formula is NH2) with a nitrite and haloboric acid at a temperature below 0*C. to yield a compound wherein X in the formula is halogen, and converting the halogen compound, if desired, to one in which X has the other definitions set forth above, in conventional manner. Alternatively, the novel compounds are prepared from open-ring diamine compounds by reacting with an alkali metal xanthogenate or an orthoformate.
摘要:
WHEREIN R1 is hydrogen or lower alkyl; R2 is phenyl or benzyl, optionally substituted by halogen, lower alkyl or lower alkoxy; and A is lower alkylene optionally substituted by a hydroxyl group; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; HAVE OUTSTANDING ANTI-OEDEMA, ANTI-INFLAMMATORY AND ANTI-ALLERGIC ACTIVITY.
摘要:
Novel phenoxyalkyl-carboxylic acid derivatives of the formula
wherein R1 and R2, which may be the same or different, are hydrogen or methyl; N IS 1 OR 2; Z is hydroxyl or alkoxy; and Y is a 5- or 6-membered heterocyclic ring containing, as hetero atoms, 1 or 2 sulfur, oxygen or nitrogen atoms, which heterocyclic ring may be substituted by halogen atoms or lower alkyl, alkoxy or alkoxyalkoxy radicals and may also contain a fused benzene nucleus, which can be substituted by halogen atoms or alkoxy or an alkylene radical; AND THE PHARMOCOLOGICALLY COMPATIBLE SALTS THEREOF, ARE OUTSTANDINGLY EFFECTIVE AS SERUM LIPID DEPRESSANTS AND ARE THUS EFFECTIVE THERAPEUTIC AGENTS IN THE TREATMENT OF ATHEROSCLEROSIS.
摘要翻译:式R1 | Y-CO-NH-(CH2)n -O-C-CO-Z | R2的新型苯氧基烷基 - 羧酸衍生物,其中可以相同或不同的R 1和R 2是氢或甲基; N IS 1 OR 2; Z是羟基或烷氧基; Y为5或6元杂环,杂环为1或2个硫,氧或氮原子,该杂环可被卤素原子或低级烷基,烷氧基或烷氧基烷氧基取代,也可含有 稠合的苯核,其可以被卤素原子或烷氧基或亚烷基取代; 并且其药理学兼容的盐,作为血清脂质沉着剂是非常有效的,并且是有效的治疗药物治疗甲状腺功能亢进症。