公开(公告)号：US3781328A

公开(公告)日：1973-12-25

申请号：US3781328D

申请日：1972-09-07

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WITTE E ,  STACH K ,  STORK H ,  THIEL M ,  SCHMIDT F

IPC分类号： A61K31/215 ,  A61K20060101 ,  A61K31/16 ,  A61K31/19 ,  A61K31/195 ,  A61K31/22 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/73 ,  C07C235/48 ,  C07C103/30

CPC分类号： Y02P20/55 ,  Y10S514/824

摘要： NOVEL PHENOXY-ALKYL-CARBOXYLIC ACID COMPOUNDS OF THE FORMULA:

(R1,R2-PHENYL)-CO-NH-(CH2)N-(1,4-PHENYLENE)-O-C(-R3)(-R4)-

AND THE PHARMACOLOGICAL COMPATIBLE SALTS THEREOF, ARE REMARKABLY EFFECTIVE IN LOWERING THE SERUM LIPID LEVEL AND CHOLESTEROL LEVEL WITHOUT INDUCING UNDESIRABLE SIDE EFFECTS.

R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN, HALOGEN, LOWER ALKYL OR LOWER ALKOXY; R3 AND R4, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN OR LOWER ALKYL; N IS 1, 2 OR 3; AND Z IS HYDROXYL OR LOWER ALKOXY;

WHEREIN

CO-Z

公开(公告)号：US3736334A

公开(公告)日：1973-05-29

申请号：US3736334D

申请日：1971-01-19

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WINTER W ,  THIEL M ,  STACH K ,  SCHMIDT F ,  STORK H

IPC分类号： C07D311/86 ,  C07D313/12 ,  C07D337/12 ,  C07D7/42

CPC分类号： C07D311/86 ,  C07C2603/18 ,  C07D313/12 ,  C07D337/12

摘要： WHEREIN X IS A VALENCY BOND, A SULFUR OR OXYGEN ATOM, A SATURATED OR UNSATURATED ALKYLENE RADICAL OR AN OXAMETHYLENE OR THIAMETHYLENE RADICAL, R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN ATOMS OR METHYL RADICALS, AND R3 IS A HYDROGEN OR HALOGEN ATOM, WHICH COMPOUNDS SERVE TO REDUCE THE CHOLESTEROL LEVEL IN BLOOD. THE PROCESS OF MAKING AND USING THE COMPOUNDS ARE ALSO COVERED.

PHENYLENE)-)

X
PHENOXYACETIC ACID ESTERS OF THE FORMULA

公开(公告)号：US3849417A

公开(公告)日：1974-11-19

申请号：US29674472

申请日：1972-10-11

申请人： BOEHRINGER MANNHEIM GMBH

发明人： HUEBNER M ,  THIEL M ,  WEYER R ,  HEERDT R ,  SCHMIDT F

IPC分类号： C07D239/69 ,  A61K20060101 ,  A61K31/33 ,  A61K31/4168 ,  A61K31/505 ,  C07D20060101 ,  C07D239/02 ,  C07D239/24 ,  C07D239/84 ,  C07D307/78 ,  C07D313/08 ,  C07D315/00 ,  C07D333/70 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D99/04 ,  C07D99/06

CPC分类号： C07D239/69 ,  Y10S514/866

摘要： 2-(A-CO-NH-Y-(2-R1-1,4-PHENYLENE)-SO2-NH-),4-R3,5-R2-

PYRIMIDINE

WHEREIN A IS AN OXYGEN- OR SULFUR-CONTAINING BICYCLIC RADICAL OF THE FORMULA

1,2-(-B-X-)-PHENYL-
WHEREIN X IS OXYGEN OR SULFUR AND B IS ALKYLENE OF UP TO 4 CARBON ATOMS OR CH=CH; AND WHEREIN SAID RADICAL MAY BE SUBSTITUTED WITH ONE OR TWO MEMBERS OF THE GROUP CONSISTING OF HALOGEN AND ALKYL AND ALKOXY HAVING NOT MORE THAN THREE CARBONS ATOMS; Y IS A STRAIGHT-CHAINED OR BRANCHED ALKYLENE CONTAINING UP TO 3 CARBON ATOMS; R1 IS A HYDROGEN ATOM OR, TOGETHER WITH Y, REPRESENTS AN ALKYLENE BRIDGE OF FROM 3 TO 4 CARBON ATOMS; R2 IS STRAIGNT-CHAINED OR BRANCHED ALKYL, CYCLOALKYL, CYCLOALKYLALKYL, ALKOXY, CYCLOALKOXY, ALKOXYALKYL, ALKOXYALKOXY, ALKYLTHIO OR ALKYLTHIOALKYL, PHENYL, OR BENZYL AND WHEREIN R2 CONTAINS NOT MORE THAN 10 CARBON ATOMS; R3 IS A HYDROGEN ATOM OR LOWER ALKYL OF FROM 1 TO 6 CARBON ATOMS; R2 AND R3 TOGETHER FORM A BRIDGE OF 3 TO 5 METHYLENE GROUPS; AS WELL AS THE PHYSIOLOGICALLY COMPATIBLE SALTS THEREOF.
1. SULFONYLAMINOPYRIMIDINE COMPOUND OF THE FORMULA

公开(公告)号：US3778350A

公开(公告)日：1973-12-11

申请号：US3778350D

申请日：1970-08-05

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BERGMEYER H ,  SCHMIDT F ,  STORK H ,  BERNT E ,  GRUBER W

IPC分类号： G01N33/66 ,  C12Q1/54 ,  G01N31/14

CPC分类号： C12Q1/54

摘要： GLUCOSE IS DETERMINED ENZYMATICALLY WITH A STABLE DIAGNOSTIC AGENT MIXTURE COMPRISING HEXOLKINASE, GLUCOSE-6PHOSPHATE DEHYDROGENASE, ATP, MAGNESIUM SULFATE, NADP. AND A BUFFER CONTAINING AN AZIDE.

公开(公告)号：US3716537A

公开(公告)日：1973-02-13

申请号：US3716537D

申请日：1970-06-01

申请人： BOEHRINGER MANNHEIM GMBH

发明人： HEERDT R ,  HUBNER M ,  SCHMIDT F ,  WEYER R

IPC分类号： A61K31/505 ,  B42F5/00 ,  C07D239/69 ,  C07D409/12 ,  C07D51/42

CPC分类号： C07D239/69 ,  C07D409/12 ,  Y10S514/866

摘要： Certain novel sulfonylaminopyrimidines having the general formula

WHEREIN A is a lower alkylene radical, B is a lower alkyl radical, X is a straight or branched-chain lower alkylene radical, R1 is a straight or branched-chain alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, e.g., phenyl or naphthyl, aralkyl, e.g., benzyl or naphthyl-ethyl, alkoxy, cycloalkoxy, alkoxyalkyl, alkoxyalkoxy or alkylmercapto radical and R2 is a hydrogen atom or a lower alkyl radical and wherein R1 and R2 can, together, also form an alkylene ring of three to five methylene radicals, as well as the physiologically compatible salts thereof, have strong blood sugar reducing activity.

摘要翻译： 某些具有通式为WHEREIN A的新型磺酰氨基嘧啶具有低级亚烷基，B为低级烷基，X为直链或支链低级亚烷基，R1为直链或支链烷基，环烷基，环烷基 - 烷基， 芳基，例如苯基或萘基，芳烷基，例如苄基或萘基 - 乙基，烷氧基，环烷氧基，烷氧基烷基，烷氧基烷氧基或烷基巯基，R2是氢原子或低级烷基，其中R1和R2可一起形成 三至五个亚甲基的亚烷基环及其生理上相容的盐具有强烈的血糖降低活性。

公开(公告)号：US3711564A

公开(公告)日：1973-01-16

申请号：US3711564D

申请日：1969-10-13

申请人： BOEHRINGER MANNHEIM GMBH

发明人： HUBNER M ,  HEERDT R ,  SCHMIDT F ,  STACH K ,  AUMULLER W

IPC分类号： C07D239/69 ,  C07D51/42

CPC分类号： C07D239/69 ,  C07C2603/18

摘要： Novel sulfonylaminopyrimidines, particularly 4-( Beta fluorenyl-(9)-acylamido-alkylene)-N-(pyrimidinyl-(2))-benzenesulfonamide compounds and the corresponding indan-5-sulfonamide compounds, exhibit outstanding antidiabetic activity.

摘要翻译： 新的磺酰氨基嘧啶，特别是4- [芴基 - （9） - 酰氨基 - 亚烷基] -N- [嘧啶基 - （2）] - 苯 - 磺酰胺化合物和相应的茚满-5-磺酰胺化合物，表现出优异的抗糖尿病活性。

公开(公告)号：US3851056A

公开(公告)日：1974-11-26

申请号：US18940971

申请日：1971-10-14

申请人： BOEHRINGER MANNHEIM GMBH

发明人： STORK H ,  SCHMIDT F ,  KAMPE W ,  THIEL M ,  FAULAND E

IPC分类号： C07H19/16 ,  A61K27/00

CPC分类号： C07H19/16

摘要： 1. METHOD OF DEPRESSING FATTY ACIDS AND TRIGLYCERIDES IN MAMMAL IN NEED OF EACH THERAPYL AN EFFECTIVE AMOUNT OF A MAMMALS, WHICH COMPRISES ADMINISTERING TO THE AFFLICTED COMPOUND OF THE GENERA FORMULA

2-R1,6-(B-X-A-N(-R2)-),9-(3,4-DI(HO-),5-(HO-CH2-)-

TETRAHYDROFUR-2-YL-)-9H-PURINE

WHEREIN R1 IS HYDROGEN, CHLORIDE, HYDROXYL OR AMINO; R2 IS HYDROGEN LOWER STRAIGHT-CHAINED OR BRANCHED ALKYL; A IS A VALENCY BOND OR STURATED OR UNSATURATED STRAIGHTCHAINED, LOWER BRANCED OR CYCLIC ALKYLENE, UNSUBSTITUTED OR SUBSTITUTED BY HYDROXYL, CARBOXYL OR LOWER ACYLOXY; X IS A VALENCY BOND OR, IF A IS ALKYLENE, CAN ALSO BE OXYGEN, SULFUR, IMINO, LOWER ALKYLATED IMINO, OR LOWER ACYLATED IMINO; B IS UNSUBSTITUTED OR SUBSTITUTED PHENYL OR NAPHTHYL WHEREIN THE SUBSTITUENTS ARE FROM 1 TO 3 MEMBERS OF THE GROUP CONSISTING OF CHLORO OR FLUORO, LOWER ALKYL, CHLORO- OR FLUORO-ALKYL, ALKOXY, ARYLOXY OF FROM 6 TO 10 CARBON ATOMS, LOWER ACYLOXY, ALKYLTHIO, CARBOXY AND HYDROXYL AND WHEREIN ANY TWO SUBSTITUENTS IN B CAN TOGETHER ALSO REPRESENT A DIOXOMETHYLENE BRIDGE; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF.

公开(公告)号：US3752851A

公开(公告)日：1973-08-14

申请号：US3752851D

申请日：1971-09-21

申请人： BOEHRINGER MANNHEIM GMBH

发明人： STACH K ,  SCHMIDT F ,  WINTER W ,  FAULAND E ,  AUMUELLER W

IPC分类号： C07D209/86 ,  C07D295/28 ,  C07D311/82 ,  C07D313/12 ,  C07D335/02 ,  C07D337/12 ,  C07D337/16 ,  C07C127/00

CPC分类号： C07D295/32 ,  C07C2603/18 ,  C07D209/86 ,  C07D311/82 ,  C07D313/12 ,  C07D335/02 ,  C07D337/12 ,  C07D337/16 ,  Y10S514/866

摘要： NOVEL SULFONYL UREAS HAVING THE FORMULA:

X
NH-R2)-(R1-1,2-PHENYLENE)-)

WHEREIN X REPRESENTS OXYGEN, SULFUR, SATURATED, UNSATURATED, STRAIGHT OR BRANCHED CHAIN ALKYLENE CONTAINING UP TO 3 CARBON ATOMS, OXYMETHYLENE, THIAMETHYLENE, THIAETHYLENE, IMINOMETHYLENE, ALKYLATED IMINOMETHYLENE, ACYLATED IMINOMETHYLENE, CARBOXIMIDO, ALKYLATED CARBOXIMIDO, OR A VALENCY BOND, R1 IS HYDROGEN, HALOGEN, ALKYL, ALKOXY OR TRIFLUOROMETHYL, Y IS SATURATED, UNSATURATED, STRAIGHT OR BRANCHED CHAIN ALKYLENE CONTAINING UP TO 6 CARBON ATOMS OR SUCH ALKYLENE GROUP CONTAINING A NITROGEN OR OXYGEN ATOM, Z IS STRAIGHT OR BRANCHED CHAIN ALKYLENE CONTAINING UP TO 4 CARBON ATOMS AND R2 IS STRAIGHT OR BRANCHED CHAIN, SATURATED OR UNSATURATED ALKYL OR CYCLOALKYL, AND SUCH GROUPS INTERRUPTED BY OXYGEN OR SULFUR ATOMS OR CONTAINING AN ENDO-ALKYLENE GROUP AND SUBSTITUTED OR UBSUBSTITUTED ARYL OR ARALKYL. THE AFORESAID SULFONYL UREAS CONSTITUTE EXTREMELY EFFECTIVE ANTI-DIABETIC AGENTS.