公开(公告)号：US3845035A

公开(公告)日：1974-10-29

申请号：US27109872

申请日：1972-07-12

申请人： BOEHRINGER MANNHEIM GMBH

发明人： KAMPE W ,  FAULAND E ,  JUHRAN W ,  STORK H

IPC分类号： C07H19/16 ,  C07D51/54

CPC分类号： C07H19/16

摘要： 1. N(6)-SUBSITUTED ADENOSINE COMPOUND OF THE FORMULA:

2-R1,6-((R3,R2-PHENYL)-CH2-NH-),9-(3,4-DI(HO-),5-(HO-

CH2-)-TETRAHYDROFUR-2-YL-)-9H-PURINE

WHEREIN R1 IS HYDROGEN, HALOGEN, AMINO, OR HYDROXYL; R2 IS CYANO OR HYDROXY-METHYL; AND R3 IS HYDROGEN, HALOGEN, LOWER ALKYL OR LOWER ALKOXY RADICAL; OR A PHARMACOLOGICALLY COMPATIBLE SALT THEREOF.

公开(公告)号：US3851056A

公开(公告)日：1974-11-26

申请号：US18940971

申请日：1971-10-14

申请人： BOEHRINGER MANNHEIM GMBH

发明人： STORK H ,  SCHMIDT F ,  KAMPE W ,  THIEL M ,  FAULAND E

IPC分类号： C07H19/16 ,  A61K27/00

CPC分类号： C07H19/16

摘要： 1. METHOD OF DEPRESSING FATTY ACIDS AND TRIGLYCERIDES IN MAMMAL IN NEED OF EACH THERAPYL AN EFFECTIVE AMOUNT OF A MAMMALS, WHICH COMPRISES ADMINISTERING TO THE AFFLICTED COMPOUND OF THE GENERA FORMULA

2-R1,6-(B-X-A-N(-R2)-),9-(3,4-DI(HO-),5-(HO-CH2-)-

TETRAHYDROFUR-2-YL-)-9H-PURINE

WHEREIN R1 IS HYDROGEN, CHLORIDE, HYDROXYL OR AMINO; R2 IS HYDROGEN LOWER STRAIGHT-CHAINED OR BRANCHED ALKYL; A IS A VALENCY BOND OR STURATED OR UNSATURATED STRAIGHTCHAINED, LOWER BRANCED OR CYCLIC ALKYLENE, UNSUBSTITUTED OR SUBSTITUTED BY HYDROXYL, CARBOXYL OR LOWER ACYLOXY; X IS A VALENCY BOND OR, IF A IS ALKYLENE, CAN ALSO BE OXYGEN, SULFUR, IMINO, LOWER ALKYLATED IMINO, OR LOWER ACYLATED IMINO; B IS UNSUBSTITUTED OR SUBSTITUTED PHENYL OR NAPHTHYL WHEREIN THE SUBSTITUENTS ARE FROM 1 TO 3 MEMBERS OF THE GROUP CONSISTING OF CHLORO OR FLUORO, LOWER ALKYL, CHLORO- OR FLUORO-ALKYL, ALKOXY, ARYLOXY OF FROM 6 TO 10 CARBON ATOMS, LOWER ACYLOXY, ALKYLTHIO, CARBOXY AND HYDROXYL AND WHEREIN ANY TWO SUBSTITUENTS IN B CAN TOGETHER ALSO REPRESENT A DIOXOMETHYLENE BRIDGE; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF.

公开(公告)号：US3817981A

公开(公告)日：1974-06-18

申请号：US19972771

申请日：1971-11-17

申请人： BOEHRINGER MANNHEIM GMBH

发明人： DIETMANN K ,  STORK H ,  JUHRAN W ,  KAMPE W ,  FAULAND E

IPC分类号： C07D239/70 ,  C07D247/00 ,  C07D487/04 ,  C07H19/16 ,  C07D51/54

CPC分类号： C07H19/16 ,  Y02P20/55 ,  Y10S514/929

摘要： WHEREIN R1 is hydrogen, halogen or hydroxyl; R2 is hydrogen, halogen, hydroxyl, alkyl or alkoxy; R3 is hydroxyl, amino, alkoxy, alkylamino or dialkylamino; and X is straight or branched-chain alkylene containing up to 3 carbon atoms; and the physiologically compatible salts thereof, ARE OUTSTANDINGLY EFFECTIVE IN PRODUCING A PROLONGED CORONARY VASODILATING EFFECT, AND FURTHERMORE, ARE EFFECTIVE IN DEPRESSING SERUM LIPIDS.

Novel N(6)-Aralkyl-Adenosine Compounds of the formula

摘要翻译： 新型N（6） - 烷基 - 腺苷式WHEREIN R1的化合物是氢，卤素或羟基; R2是氢，卤素，羟基，烷基或烷氧基; R3是羟基，氨基，烷氧基，烷基氨基或二烷基氨基; 并且X是含有至多3个碳原子的直链或支链亚烷基; 和其生理上相容的盐，在产生冠状动脉血管扩张作用方面是非常有效的，而且在进一步减少血清脂质中有效。

公开(公告)号：US3787391A

公开(公告)日：1974-01-22

申请号：US3787391D

申请日：1971-11-22

申请人： BOEHRINGER MANNHEIM GMBH

发明人： FAULAND E ,  JUHRAN W ,  JAHN W ,  KAMPE W ,  STORK H

IPC分类号： C07D239/70 ,  A61K31/522 ,  C07C243/38 ,  C07H19/16 ,  C07H19/167 ,  C07D51/54

CPC分类号： C07H19/16 ,  C07C243/38 ,  Y02P20/55

摘要： NEW ADENOSINE COMPOUNDS OF THE FORMULA:

2-R1,6-((R2,(R3-NH-NH-CO-)PHENYL)-X-A-NH-),9-(3,4-DI(HO-),

5-(HO-CH2-)-TETRAHYDROFURAN-2-YL)-9H-PURINE

WHERE R1 IS HYDROGRN OR HALOGEN; R2 IS HYDROGEN, HALOGEN, HYDROXYL, ALKYL OR ALKOXY; R3 IS HYDROGEN OR -CO-R4, WHEREIN R4 IS ARYL WHICH IS OPTIONALLY SUBSTITUTED ONE OR MORE TIMES BY HALOGEN AND/OR LKYL, ALKOXY AND/OR HYDROXYALKYLENEOXY; A IS A STRAIGHTCHAINED OR BRANCHED ALKYLENE RADICAL CONTAINING UP TO 3 CARBON ATOMS AND X IS A VALENCY BOND OR OXYGEN: AND THE PHYSIOLOGICALLY COMPATIBLE SALTS THEREOF, EXHIBIT REMARKABLE EFFECTIVENES IN IMPROVING THE BLOOD CIRCULATION OF MAMMALS AND ALSO BRING ABOUT A DEPRESSION OF SERUM LIPIDS.

公开(公告)号：US3778350A

公开(公告)日：1973-12-11

申请号：US3778350D

申请日：1970-08-05

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BERGMEYER H ,  SCHMIDT F ,  STORK H ,  BERNT E ,  GRUBER W

IPC分类号： G01N33/66 ,  C12Q1/54 ,  G01N31/14

CPC分类号： C12Q1/54

摘要： GLUCOSE IS DETERMINED ENZYMATICALLY WITH A STABLE DIAGNOSTIC AGENT MIXTURE COMPRISING HEXOLKINASE, GLUCOSE-6PHOSPHATE DEHYDROGENASE, ATP, MAGNESIUM SULFATE, NADP. AND A BUFFER CONTAINING AN AZIDE.

公开(公告)号：US3840521A

公开(公告)日：1974-10-08

申请号：US28711572

申请日：1972-09-07

申请人： BOEHRINGER MANNHEIM GMBH

发明人： FAULAND E ,  KAMPE W ,  ROESCH E ,  THIEL M ,  STORK H

IPC分类号： C07H19/16 ,  C07D51/54

CPC分类号： C07H19/16

摘要： 1. N(6)-DISUBSTITUTED ADENOSINE COMPOUND OF THE FORMULA

6-(R1-N(-R2)-),9-(3,4,5-TRI(HO-)-TETRAHYROFUR-2-YL-)-

9H-PURINE

WHEREIN R1 IS ALKYL OF FROM 1 TO 6 CARBON ATOMS; AND R2 IS STRAIGHT-CHAINED OR BRANCHED ALKYL OF FROM 4 TO 10 CARBON ATOMS; CYCLOALKYL OR METHYLCYCLOALKYL WHEREIN THE CYCLOALKYL MOIETY CONTAINS FROM 3 TO 10 CARBON ATOMS, CYCLOALKYL-ALKYL WITH FROM 3 TO 10 CARBON ATOMS IN THE CYCLOALKYL GROUP AND FROM 1 TO 4 CARBON ATOMS IN THE ALKYL SIDE-CHAIN OR BICYCLOALKYL OF FROM 5 TO 7 CARBON ATOMS IN EACH RING; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF.

公开(公告)号：US3781328A

公开(公告)日：1973-12-25

申请号：US3781328D

申请日：1972-09-07

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WITTE E ,  STACH K ,  STORK H ,  THIEL M ,  SCHMIDT F

IPC分类号： A61K31/215 ,  A61K20060101 ,  A61K31/16 ,  A61K31/19 ,  A61K31/195 ,  A61K31/22 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/73 ,  C07C235/48 ,  C07C103/30

CPC分类号： Y02P20/55 ,  Y10S514/824

摘要： NOVEL PHENOXY-ALKYL-CARBOXYLIC ACID COMPOUNDS OF THE FORMULA:

(R1,R2-PHENYL)-CO-NH-(CH2)N-(1,4-PHENYLENE)-O-C(-R3)(-R4)-

AND THE PHARMACOLOGICAL COMPATIBLE SALTS THEREOF, ARE REMARKABLY EFFECTIVE IN LOWERING THE SERUM LIPID LEVEL AND CHOLESTEROL LEVEL WITHOUT INDUCING UNDESIRABLE SIDE EFFECTS.

R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN, HALOGEN, LOWER ALKYL OR LOWER ALKOXY; R3 AND R4, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN OR LOWER ALKYL; N IS 1, 2 OR 3; AND Z IS HYDROXYL OR LOWER ALKOXY;

WHEREIN

CO-Z

公开(公告)号：US3751408A

公开(公告)日：1973-08-07

申请号：US3751408D

申请日：1971-05-21

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BERGMEYER H ,  STORK H ,  WEIMANN G ,  MICHAEL G ,  NELBOECK HOCHSTETTER M

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7056 ,  A61P3/06 ,  C07H19/052 ,  C07D51/52

CPC分类号： C07H19/052

摘要： CERTAIN NOVEL IMIDAZOLE-RIBOSYL CYCLOPHOSPHATE COMPOUNDS OF THE GENERAL FORMULA:

1-(3-HO,4,5-(-O-P(=O)(-OH)-O-CH2-)TETRAHYDROFUR-2-YL),

WHEREIN R IS A HYDROGEN ATOM OR A (CH2)N-A RADICAL, IN WHICH N IS 2 OR 3 A IS A SULFO OR COR'' GROUP AND R'' IS HYDROXYL, ALKOXY CONTAINING FROM 1 TO 6 CARBON ATOMS OR PROPIONAMIDO; AND THE SALTS THERREOF ARE OUTSTANDINGLY EFFECTIVE ANTI-HYPERLIPEMIC AGENTS AND, PARTICULARLY, AS ANTI-CHOLESTEROL AGENTS.

4-(R-NH-CO-),5-NH2-IMIDAZOLE

公开(公告)号：US3736334A

公开(公告)日：1973-05-29

申请号：US3736334D

申请日：1971-01-19

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WINTER W ,  THIEL M ,  STACH K ,  SCHMIDT F ,  STORK H

IPC分类号： C07D311/86 ,  C07D313/12 ,  C07D337/12 ,  C07D7/42

CPC分类号： C07D311/86 ,  C07C2603/18 ,  C07D313/12 ,  C07D337/12

摘要： WHEREIN X IS A VALENCY BOND, A SULFUR OR OXYGEN ATOM, A SATURATED OR UNSATURATED ALKYLENE RADICAL OR AN OXAMETHYLENE OR THIAMETHYLENE RADICAL, R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN ATOMS OR METHYL RADICALS, AND R3 IS A HYDROGEN OR HALOGEN ATOM, WHICH COMPOUNDS SERVE TO REDUCE THE CHOLESTEROL LEVEL IN BLOOD. THE PROCESS OF MAKING AND USING THE COMPOUNDS ARE ALSO COVERED.

PHENYLENE)-)

X
PHENOXYACETIC ACID ESTERS OF THE FORMULA