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13 条记录 (耗时 0.011 秒)

    Method of depressing fatty acids and triglycerides
    3.
    发明授权
    Method of depressing fatty acids and triglycerides 失效
    消除脂肪酸和苦味酸的方法

    公开(公告)号：US3851056A

    公开(公告)日：1974-11-26

    申请号：US18940971

    申请日：1971-10-14

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： STORK H ,  SCHMIDT F ,  KAMPE W ,  THIEL M ,  FAULAND E

    IPC分类号： C07H19/16 ,  A61K27/00

    CPC分类号： C07H19/16

    摘要： 1. METHOD OF DEPRESSING FATTY ACIDS AND TRIGLYCERIDES IN MAMMAL IN NEED OF EACH THERAPYL AN EFFECTIVE AMOUNT OF A MAMMALS, WHICH COMPRISES ADMINISTERING TO THE AFFLICTED COMPOUND OF THE GENERA FORMULA

    2-R1,6-(B-X-A-N(-R2)-),9-(3,4-DI(HO-),5-(HO-CH2-)-

    TETRAHYDROFUR-2-YL-)-9H-PURINE

    WHEREIN R1 IS HYDROGEN, CHLORIDE, HYDROXYL OR AMINO; R2 IS HYDROGEN LOWER STRAIGHT-CHAINED OR BRANCHED ALKYL; A IS A VALENCY BOND OR STURATED OR UNSATURATED STRAIGHTCHAINED, LOWER BRANCED OR CYCLIC ALKYLENE, UNSUBSTITUTED OR SUBSTITUTED BY HYDROXYL, CARBOXYL OR LOWER ACYLOXY; X IS A VALENCY BOND OR, IF A IS ALKYLENE, CAN ALSO BE OXYGEN, SULFUR, IMINO, LOWER ALKYLATED IMINO, OR LOWER ACYLATED IMINO; B IS UNSUBSTITUTED OR SUBSTITUTED PHENYL OR NAPHTHYL WHEREIN THE SUBSTITUENTS ARE FROM 1 TO 3 MEMBERS OF THE GROUP CONSISTING OF CHLORO OR FLUORO, LOWER ALKYL, CHLORO- OR FLUORO-ALKYL, ALKOXY, ARYLOXY OF FROM 6 TO 10 CARBON ATOMS, LOWER ACYLOXY, ALKYLTHIO, CARBOXY AND HYDROXYL AND WHEREIN ANY TWO SUBSTITUENTS IN B CAN TOGETHER ALSO REPRESENT A DIOXOMETHYLENE BRIDGE; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF.

    Flavonyloxyalkyl-piperazine compounds
    5.
    发明授权
    Flavonyloxyalkyl-piperazine compounds 失效
    氟草酰胺 - 哌嗪化合物

    公开(公告)号：US3810896A

    公开(公告)日：1974-05-14

    申请号：US24213472

    申请日：1972-04-07

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： WITTE E ,  STACH K ,  ROESCH E ,  THIEL M ,  ROESCH A

    IPC分类号： C07D311/30 ,  C07D51/70

    CPC分类号： C07D311/30

    摘要： CERTAIN NOVEL 4-(FLAVON-7-OYLOXY)-ALKYL)-PIPERAZINE COMPOUNDS OF THE FORMULA

    2-PHENYL,7-((4-R-PIPERAZINO)-(CH2)N-O-)-4H-CHROMEN-4-ONE

    WHEREIN R IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS BEING HALOGEN ATOMS OR LOWER ALKYL OR ALKOXY RADICALS, E.G., OF FROM 1 TO 6 CARBON ATOMS, AND N IS 1, 2 OR 3; AND THE PHRMACOLOGICALLY COMPATIBLE SALTS THEREOF. HAVE OUTSTANDING ANTI-EDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.

    Pyrido(2,3-d)pyrimidin-4(3h)-ones
    6.
    发明授权
    Pyrido(2,3-d)pyrimidin-4(3h)-ones 失效
    吡啶（2,3-D）嘧啶-4（3H） - 酮

    公开(公告)号：US3794637A

    公开(公告)日：1974-02-26

    申请号：US3794637D

    申请日：1971-07-22

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： WIEDEMANN F ,  THIEL M ,  HARDEBECK K ,  STACH K ,  ROESCH E

    IPC分类号： C07D471/04 ,  C07D51/46

    CPC分类号： C07D471/04 ,  Y10S514/869

    摘要： PYRIDO-(2,3-D)PYRIMIDIN-4(3H)-ONES OF THE GENERAL FORMULA 2-(R1-N(-R2)-),4-(O=)-3,4-DIHYDROPYRIDO(2,3-D)PYRIMIDINE WHEREIN R1 IS A LOWER ALKYL, ALKENUL, CYCLOALKYL, ARALKYL, FURYLALKYL, THIENYLALKYL OR TETRAHYDROFURYLALKYL RADICAL, OPTIONALLY SUBSTITUTED BY HYDROXY. ALKOXY OR ALKYLMERCAPTO RADICALS AND R2 IS R1 OR HYDROGEN, AND THE SALTS THEREOF WITH PHYSIOLOGICALLY COMPATIBLE ACIDS. THESE COMPOUNDS EXHIBIT LONGLASTING DIURETIC ACTION.

    N(6)-benzyl-adenosine compounds and therapeutic compositions
    7.
    发明授权
    N(6)-benzyl-adenosine compounds and therapeutic compositions 失效
    N（6） - 苯亚胺化合物和治疗组合物

    公开(公告)号：US3781273A

    公开(公告)日：1973-12-25

    申请号：US3781273D

    申请日：1971-02-03

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： KAMPE W ,  DIETMANN K ,  JUHRAN W ,  FAULAND E ,  THIEL M

    IPC分类号： C07H19/167 ,  C07H19/16 ,  C07D51/54

    CPC分类号： C07H19/16

    摘要： NOVEL 2,3- OR 2-5 DISUBSTITUTED N (6)-BENZYL-ADENOSINE DERIVATIVES OF THE FOLLOWING FORMULA

    9-(3,4,5-TRI(HO-)TETRAHYDROFUR-2-YL),6-((2-R1,3-R2,5-R3-

    PHENYL)-CH2-NH-)-9H-PURINE

    WHEREIN

    R1 IS HALOGEN, ALKYL, ALKOXY OR ALKYLTHIO; R2 AND R3 ARE MEMBERS OF THE GROUP CONSISTING OF HYDROGEN, HALOGEN, ALKYL, ALKOXY AND ALKYLTHIO WITH THE PROVISO THAT ONE AND ONLY ONE OF R2 AND R3 IS HYDROGEN; ARE OUTSTANDING EFFECTIVE CORONARY DILATORS AND LOWER THE FREE FATTY ACID CONTENT OF SERUM.

    N(6)-disubstituted adenosine compounds
    8.
    发明授权
    N(6)-disubstituted adenosine compounds 失效
    N（6） - 衍生腺苷化合物

    公开(公告)号：US3840521A

    公开(公告)日：1974-10-08

    申请号：US28711572

    申请日：1972-09-07

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： FAULAND E ,  KAMPE W ,  ROESCH E ,  THIEL M ,  STORK H

    IPC分类号： C07H19/16 ,  C07D51/54

    CPC分类号： C07H19/16

    摘要： 1. N(6)-DISUBSTITUTED ADENOSINE COMPOUND OF THE FORMULA

    6-(R1-N(-R2)-),9-(3,4,5-TRI(HO-)-TETRAHYROFUR-2-YL-)-

    9H-PURINE

    WHEREIN R1 IS ALKYL OF FROM 1 TO 6 CARBON ATOMS; AND R2 IS STRAIGHT-CHAINED OR BRANCHED ALKYL OF FROM 4 TO 10 CARBON ATOMS; CYCLOALKYL OR METHYLCYCLOALKYL WHEREIN THE CYCLOALKYL MOIETY CONTAINS FROM 3 TO 10 CARBON ATOMS, CYCLOALKYL-ALKYL WITH FROM 3 TO 10 CARBON ATOMS IN THE CYCLOALKYL GROUP AND FROM 1 TO 4 CARBON ATOMS IN THE ALKYL SIDE-CHAIN OR BICYCLOALKYL OF FROM 5 TO 7 CARBON ATOMS IN EACH RING; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF.

    Amino acid derivatives
    10.
    发明授权
    Amino acid derivatives 失效
    氨基酸衍生物

    公开(公告)号：US3793365A

    公开(公告)日：1974-02-19

    申请号：US3793365D

    申请日：1970-04-10

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： WINTER W ,  THIEL M ,  STACH K ,  DIETMANN K ,  BARTSCH W

    IPC分类号： A41B3/00 ,  A61K31/195 ,  C07C237/00 ,  C07D265/32 ,  C07D295/12 ,  C07C101/08

    CPC分类号： C07D295/12 ,  A41B3/00 ,  A61K31/195 ,  C07C237/00 ,  C07D265/32

    摘要： NEW AMINO ACID DERIVATIVES OF THE FORMULA

    R1-O-CH2-CH(-OH)-CH2-N(-R2)-A-CO-R3

    WHEREIN R1 IS ARYL, SUCH AS NAPHTHYL OR PHENYL, WHICH MAY BE SUBSTITUTED BY HALOGEN OR HYDROXYL, ALKOXY, ALKENYL, ALKENYLOXY, ALKYL, ALKOXYALKYL, TRIFLUOROALKYL, ALKYLMERCAPTO, ALKENYLMERCAPTO, AMINO, ALKYLSULFONYLAMINO, OR ACYLAMINO; R1 MAY ALSO BE INDENYL OR HYDROGENATED INDENYL OR HYDROGENATED NAPHTHYL; R2 IS HYDROGEN OR LOWER ALKYL OR ARALKYL; R3 IS HYDROXYL OR AMINO OT ALKOXY, ALKYLAMINO OR DIALKYLAMINO, OR AN N-PIPERAZYL RADICAL, WHICH MAY BE N''-SUBSTITUTED; AND A IS AN ALKYLATED, OR ARYLATED LOWER ALKYLENE CHAIN, WHICH CAN CARRY A FURTHER CARBOXYL OR CARBALKOXY RADICAL; AND THE PHYSIOLOGICALLY COMPATIBLE SALTS THEREOF; ARE OUTSTANDINGLY EFFECTIVE AS B-ADRENERGIC AGENTS.