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    Nitroimidazolyl-triazolo-pyridazine compounds
    1.
    发明授权
    Nitroimidazolyl-triazolo-pyridazine compounds 失效
    硝基咪唑基 - 三唑并 - 哒嗪化合物

    公开(公告)号：US3928349A

    公开(公告)日：1975-12-23

    申请号：US33609973

    申请日：1973-02-26

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： BERGER HERBERT ,  GALL RUDI ,  STACH KURT ,  VOMEL WOLFGANG ,  HOFFMANN RITA

    IPC分类号： A61K31/50 ,  A61P31/04 ,  C07D403/04 ,  C07D487/04 ,  C07D237/00

    CPC分类号： C07D487/04

    摘要： Nitroimidazolyl-s-triazolo(4,3-b)pyridazines of the formula:
    wherein R1 and R2 are, individually, hydrogen or a numbe organic radicals or, taken together, can be an alkylene bridge; AND R3 is hydrogen or lower alkyl; or, together with R2, R3 can form an alkylene bridge; N IS 0 OR 1; AND THE PHARMACEUTICALLY COMPATIBLE THEREOF, POSSESS HIGH IN VIVO EFFECTIVENESS AS ANTIMICROBIALS.

    WHEREIN R is hydrogen or lower alkyl optionally substituted in the 2position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula:

    摘要翻译： 具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪

    Nitrofuryl-triazolo(4,3-b)pyridazine compounds and bacteriostatic compositions
    2.
    发明授权
    Nitrofuryl-triazolo(4,3-b)pyridazine compounds and bacteriostatic compositions 失效
    硝基糠基 - 三唑并（4,3-b）哒嗪化合物和抑菌组合物

    公开(公告)号：US3928342A

    公开(公告)日：1975-12-23

    申请号：US31619772

    申请日：1972-12-18

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： BERGER HERBERT ,  GALL RUDI ,  THIEL MAX ,  VOMEL WOLFGANG ,  SAUER WINFRIEDE

    IPC分类号： C07D487/04 ,  C07D295/04 ,  C07D237/00

    CPC分类号： C07D487/04

    摘要： Nitrofuryl-triazolo(4,3-b)pyridazine compounds of the formula

    WHEREIN R1 is lower alkoxy radical or a saturated 5- or 6-membered heterocyclic ring attached via a cyclic nitrogen atom, which heterocyclic ring can also contain, in addition to said cyclic nitrogen atom, a cyclic oxygen atom or an optionally lower alkylated cyclic nitrogen atom and R2 is a hydrogen atom or R1 and R2 together represent an additional valency bond, ARE OUTSTANDINGLY EFFECTIVE AS BACTERIOSTATS AND ARE PARTICULARLY USEFUL IN THE TREATMENT OF BACTERIAL INFECTIONS IN THE URINARY TRACT.

    摘要翻译： 具有式WHERE R1的硝基糠基 - 三唑并[4,3-b]哒嗪化合物是低级烷氧基或通过环状氮原子连接的饱和的5-或6-元杂环，该杂环除了所述 环状氮原子，环状氧原子或任选的低级烷基化环状氮原子，R 2是氢原子，或者R 1和R 2一起代表额外的价键，作为细菌的特异性有效，特别是在治疗细菌感染中有用 URINARY TRACT。

    Certain nitrofuryl(hydrazino)pyrimidines
    5.
    发明授权
    Certain nitrofuryl(hydrazino)pyrimidines 失效
    某些硝酸（羟丙基）嘧啶

    公开(公告)号：US3706745A

    公开(公告)日：1972-12-19

    申请号：US3706745D

    申请日：1970-02-10

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： BERGER HERBERT ,  GALL RUDI ,  MERDES HARTMUT ,  STACH KURT ,  SAUER WINFRIEDE ,  VOMEL WOLFGANG

    IPC分类号： A61K31/505 ,  C07D405/04 ,  H01R4/38 ,  C07D51/42

    CPC分类号： A61K31/505 ,  C07D405/04

    摘要： NOVEL HYDRAZINO-PYRIMIDINES OF THE FORMULA

    R1,R2,(R4-N(-R5)-N(-R3)-),(5-(O2N-)FURAN-2-YL)PYRIMIDINE

    WHEREIN R1 IS HYDROGEN OR LOWER ALKYL OR AZIDO; R2 IS HYDROGEN OR LOWER ALKYL; AND R3, R4 AND R5, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN OR LOWER ALKYL, LOWER ACYL, LOWER CARBALKOXY, LOWER ALKYL-SULFONYL, CARBAMYL, THIOCARBAMYL OR GUANYL; AND TH EPHYSIOLOGICALLY COMPATIBLE SALTS THEREOF, ESPECIALLY THOSE WHEREIN THE HYDRAZINE FUNCTION IS IN THE 4-POSITION, R2 IS IN THE 5-POSITION, AND THE NITROFURYL RING IS IN THE 2-POSITION OF THE PYRIMIDINE RING, ARE OUTSTANDINGLY ACTIVE IN VIVO IN THE TREATMENT OF URINARY TRACT INFECTIONS.