公开(公告)号：US3781328A

公开(公告)日：1973-12-25

申请号：US3781328D

申请日：1972-09-07

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WITTE E ,  STACH K ,  STORK H ,  THIEL M ,  SCHMIDT F

IPC分类号： A61K31/215 ,  A61K20060101 ,  A61K31/16 ,  A61K31/19 ,  A61K31/195 ,  A61K31/22 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/73 ,  C07C235/48 ,  C07C103/30

CPC分类号： Y02P20/55 ,  Y10S514/824

摘要： NOVEL PHENOXY-ALKYL-CARBOXYLIC ACID COMPOUNDS OF THE FORMULA:

(R1,R2-PHENYL)-CO-NH-(CH2)N-(1,4-PHENYLENE)-O-C(-R3)(-R4)-

AND THE PHARMACOLOGICAL COMPATIBLE SALTS THEREOF, ARE REMARKABLY EFFECTIVE IN LOWERING THE SERUM LIPID LEVEL AND CHOLESTEROL LEVEL WITHOUT INDUCING UNDESIRABLE SIDE EFFECTS.

R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN, HALOGEN, LOWER ALKYL OR LOWER ALKOXY; R3 AND R4, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN OR LOWER ALKYL; N IS 1, 2 OR 3; AND Z IS HYDROXYL OR LOWER ALKOXY;

WHEREIN

CO-Z

公开(公告)号：US3810896A

公开(公告)日：1974-05-14

申请号：US24213472

申请日：1972-04-07

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WITTE E ,  STACH K ,  ROESCH E ,  THIEL M ,  ROESCH A

IPC分类号： C07D311/30 ,  C07D51/70

CPC分类号： C07D311/30

摘要： CERTAIN NOVEL 4-(FLAVON-7-OYLOXY)-ALKYL)-PIPERAZINE COMPOUNDS OF THE FORMULA

2-PHENYL,7-((4-R-PIPERAZINO)-(CH2)N-O-)-4H-CHROMEN-4-ONE

WHEREIN R IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS BEING HALOGEN ATOMS OR LOWER ALKYL OR ALKOXY RADICALS, E.G., OF FROM 1 TO 6 CARBON ATOMS, AND N IS 1, 2 OR 3; AND THE PHRMACOLOGICALLY COMPATIBLE SALTS THEREOF. HAVE OUTSTANDING ANTI-EDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.