公开(公告)号：US20160333013A1

公开(公告)日：2016-11-17

申请号：US15150492

申请日：2016-05-10

Applicant: Bristol-Myers Squibb Company

Inventor： Derek J. Norris ,  Wayne Vaccaro ,  Mikkel V. DeBenedetto ,  Andrew P. Degnan ,  George V. Delucca ,  Jeffrey A. Deskus ,  Wen-Ching Han ,  Godwin Kwame Kumi ,  William D. Schmitz ,  John E. Starrett, JR. ,  Matthew D. Hill ,  Hong Huang

IPC: C07D471/14 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/444 ,  A61K31/541 ,  A61K31/675 ,  A61K31/4545 ,  C07D519/00 ,  A61K31/439 ,  A61K31/554 ,  C07F9/6561 ,  A61K31/683 ,  A61K31/4375 ,  A61K31/519

CPC classification number: C07D471/14 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/554 ,  A61K31/675 ,  A61K31/683 ,  C07D519/00 ,  C07F9/6561

Abstract: The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract translation: 其中所有取代基在本文中定义，以及包含本发明化合物的药学上可接受的组合物以及使用所述组合物治疗各种疾病的方法。

公开(公告)号：US09725449B2

公开(公告)日：2017-08-08

申请号：US15150492

申请日：2016-05-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Derek J. Norris ,  Wayne Vaccaro ,  Mikkel V. DeBenedetto ,  Andrew P. Degnan ,  George V. Delucca ,  Jeffrey A. Deskus ,  Wen-Ching Han ,  Godwin Kwame Kumi ,  William D. Schmitz ,  John E. Starrett, Jr. ,  Matthew D. Hill ,  Hong Huang

IPC: C07D471/14 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/554 ,  A61K31/675 ,  A61K31/683 ,  C07D519/00 ,  C07F9/6561

CPC classification number: C07D471/14 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/554 ,  A61K31/675 ,  A61K31/683 ,  C07D519/00 ,  C07F9/6561

Abstract: The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US10174024B2

公开(公告)日：2019-01-08

申请号：US15573151

申请日：2016-05-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Wen-Ching Han ,  Andrew P. Degnan ,  Jeffrey A. Deskus ,  Ashvinikumar V. Gavai ,  Patrice Gill ,  William D. Schmitz ,  John E. Starrett, Jr.

IPC: C07D471/04

Abstract: The present invention is directed to tricyclic compounds of formula (I), pharmaceutically acceptable compositions comprising compounds of the invention and said compositions for use in methods for the treatment of various disorders in particular cancer.