公开(公告)号：US09751879B2

公开(公告)日：2017-09-05

申请号：US15219611

申请日：2016-07-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Derek J. Norris ,  George V. Delucca ,  Ashvinikumar V. Gavai ,  Claude A. Quesnelle ,  Patrice Gill ,  Daniel O'Malley ,  Wayne Vaccaro ,  Francis Y. Lee ,  Mikkel V. DeBenedetto ,  Andrew P. Degnan ,  Haiquan Fang ,  Matthew D. Hill ,  Hong Huang ,  William D. Schmitz ,  John E. Starrett, Jr. ,  Wen-Ching Han ,  John S. Tokarski ,  Sunil Kumar Mandal

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US09725449B2

公开(公告)日：2017-08-08

申请号：US15150492

申请日：2016-05-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Derek J. Norris ,  Wayne Vaccaro ,  Mikkel V. DeBenedetto ,  Andrew P. Degnan ,  George V. Delucca ,  Jeffrey A. Deskus ,  Wen-Ching Han ,  Godwin Kwame Kumi ,  William D. Schmitz ,  John E. Starrett, Jr. ,  Matthew D. Hill ,  Hong Huang

IPC: C07D471/14 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/554 ,  A61K31/675 ,  A61K31/683 ,  C07D519/00 ,  C07F9/6561

CPC classification number: C07D471/14 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/554 ,  A61K31/675 ,  A61K31/683 ,  C07D519/00 ,  C07F9/6561

Abstract: The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US10174024B2

公开(公告)日：2019-01-08

申请号：US15573151

申请日：2016-05-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Wen-Ching Han ,  Andrew P. Degnan ,  Jeffrey A. Deskus ,  Ashvinikumar V. Gavai ,  Patrice Gill ,  William D. Schmitz ,  John E. Starrett, Jr.

IPC: C07D471/04

Abstract: The present invention is directed to tricyclic compounds of formula (I), pharmaceutically acceptable compositions comprising compounds of the invention and said compositions for use in methods for the treatment of various disorders in particular cancer.