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公开(公告)号:US20120202782A1
公开(公告)日:2012-08-09
申请号:US13445644
申请日:2012-04-12
申请人: Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
发明人: Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
IPC分类号: A61K31/536 , A61K31/551 , A61K31/496 , A61K31/4985 , C07D487/08 , A61K31/538 , C07D401/14 , A61K31/517 , A61P37/06 , A61P29/00 , A61P19/02 , A61P17/06 , A61P7/06 , A61P35/00 , C07D413/14
CPC分类号: C07D413/14 , C07D413/02
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的B细胞活性有关的疾病或病症的方法,特别是涉及肌醇1,4异常活化的疾病或病症, 5-三磷酸3-激酶B(ITPKb)。
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公开(公告)号:US20100184748A1
公开(公告)日:2010-07-22
申请号:US12664651
申请日:2008-06-12
申请人: Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
发明人: Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
IPC分类号: A61K31/536 , C07D413/14 , A61K31/551 , A61P35/00
CPC分类号: C07D413/14 , C07D413/02
摘要: The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
摘要翻译: 本发明提供了一类新颖的式(I)化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的B细胞活性有关的疾病或病症的方法,特别是涉及异常活化的疾病或病症 肌醇1,4,5-三磷酸3-激酶B(ITPKb)。
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公开(公告)号:US08178526B2
公开(公告)日:2012-05-15
申请号:US12664651
申请日:2008-06-12
申请人: Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
发明人: Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
IPC分类号: C07D413/02 , C07D413/14 , A61K31/536 , A61K31/551
CPC分类号: C07D413/14 , C07D413/02
摘要: The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
摘要翻译: 本发明提供了一类新颖的式(I)化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调B细胞活性相关的疾病或病症的方法,特别是涉及异常活化的疾病或病症 肌醇1,4,5-三磷酸3-激酶B(ITPKb)。
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公开(公告)号:US20090306039A1
公开(公告)日:2009-12-10
申请号:US12374481
申请日:2007-07-20
申请人: Shifeng Pan , Yi Liu , Yun Feng Xie , Dai Cheng , yongqin Wan , Dong Han , Yang Yang , Wenqi Gao , Jiqing Jiang , Badry Bursulaya , Philip Chamberlain , Donald Karanewsky , Xia Wang
发明人: Shifeng Pan , Yi Liu , Yun Feng Xie , Dai Cheng , yongqin Wan , Dong Han , Yang Yang , Wenqi Gao , Jiqing Jiang , Badry Bursulaya , Philip Chamberlain , Donald Karanewsky , Xia Wang
IPC分类号: A61K31/496 , C07D403/06 , C07D401/14 , C07D403/14 , C07D413/14 , A61K31/506 , A61K31/551 , A61K31/5377
CPC分类号: C07D401/12 , C07D231/12 , C07D401/14 , C07D413/14 , C07D487/08 , C07D491/04
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的B细胞活性相关的疾病或病症的方法,特别是涉及肌醇1,4异常活化的疾病或病症, 5-三磷酸3-激酶B(ITPKb)。
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公开(公告)号:US07501408B2
公开(公告)日:2009-03-10
申请号:US11932679
申请日:2007-10-31
申请人: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
发明人: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
IPC分类号: C07D417/12 , C07D295/10 , A61K31/541
CPC分类号: C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula (I): wherein Q is thiomorpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
摘要翻译: 本发明提供了用于选择性抑制组织蛋白酶S的化合物,组合物和方法。在优选的方面,组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地,本发明提供具有式(I)的化合物:其中Q是硫代吗啉基; A,R5,R6,R7,R8,R9和Ar为取代基。
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公开(公告)号:US07314872B2
公开(公告)日:2008-01-01
申请号:US10922515
申请日:2004-08-18
申请人: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
发明人: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
IPC分类号: C07D413/12 , C07D295/10 , A61K31/5377 , A61K31/5375
CPC分类号: C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula I: wherein Q is morpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
摘要翻译: 本发明提供了选择性抑制组织蛋白酶S的化合物,组合物和方法。在优选的方面,组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地,本发明提供具有式I的化合物:其中Q是吗啉基; 和A,R 5,R 6,R 7,R 8,R 9, SUP>和Ar是取代基。
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公开(公告)号:US20100204200A1
公开(公告)日:2010-08-12
申请号:US12764772
申请日:2010-04-21
申请人: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
发明人: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
IPC分类号: A61K31/5377 , C07D413/12 , C07D295/145 , C07D413/14 , C07C245/00 , C07D401/12 , C07D403/12 , A61K31/5375 , A61K31/54 , A61K31/496 , A61K31/404
CPC分类号: C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula 1: wherein Q is an optionally substituted azetidinyl, pyrrolidinyl, piperidyl, and indolinyl; or Q is NR25R26; and A, R5, R6, R7, R8, R9, R25, R26 and Ar are substituents.
摘要翻译: 本发明提供了选择性抑制组织蛋白酶S的化合物,组合物和方法。在优选的方面,组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地,本发明提供了具有式1的化合物:其中Q是任选取代的氮杂环丁烷基,吡咯烷基,哌啶基和二氢吲哚基; 或Q为NR25R26; A,R 5,R 6,R 7,R 8,R 9,R 25,R 26和Ar为取代基。
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公开(公告)号:US07495016B2
公开(公告)日:2009-02-24
申请号:US10690873
申请日:2003-10-21
申请人: Baogen Wu , Yun He , Truc Ngoc Nguyen , Kelli L. Kuhen , David Archer Ellis , Tao Jiang , Xiaohui He , Kunyong Yang , Badry Bursulaya
发明人: Baogen Wu , Yun He , Truc Ngoc Nguyen , Kelli L. Kuhen , David Archer Ellis , Tao Jiang , Xiaohui He , Kunyong Yang , Badry Bursulaya
IPC分类号: A61K31/443 , A61K31/402 , C07D401/04 , C07D207/08
CPC分类号: C07D207/26 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要: The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.
摘要翻译: 本发明涉及使用吡咯烷酮和与吡咯烷酮有关的化合物来抑制病毒,例如HIV。 本发明还涉及用于鉴定和使用试剂的方法,包括抑制细胞中HIV的小分子化学组合物; 以及与艾滋病毒感染和相关疾病状态如艾滋病相关的预防和治疗方法。
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公开(公告)号:US20150152083A1
公开(公告)日:2015-06-04
申请号:US14405694
申请日:2013-06-05
申请人: Gerald Lelais , Robert Epple , Pierre-Yves Michellys , Badry Bursulaya , Songchun Jiang , Thomas H. Marsilje III , Matthew MCneill
发明人: Gerald Lelais , Robert Epple , Pierre-Yves Michellys , Badry Bursulaya , Songchun Jiang , Thomas H. Marsilje III , Matthew MCneill
IPC分类号: C07D401/12 , A61K31/5377 , A61K45/06 , A61K31/4439 , C07D235/30 , A61K31/4184
CPC分类号: C07D401/12 , A61K31/4184 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D235/30 , Y02A50/411
摘要: The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated EGFR activity.
摘要翻译: 本发明提供了可用于调节EGFR活性的化合物及其药物组合物,以及使用这些化合物治疗,改善或预防与异常或失调的EGFR活性相关的病症的方法。
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公开(公告)号:US08440681B2
公开(公告)日:2013-05-14
申请号:US12675379
申请日:2008-08-27
申请人: Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Xiaohui He , Badry Bursulaya , Christian Cho-Hua Lee
发明人: Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Xiaohui He , Badry Bursulaya , Christian Cho-Hua Lee
IPC分类号: A61K31/4965 , A61K31/497 , C07D239/48
CPC分类号: C07D403/12 , C07D239/48 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The invention provides novel pyrimidine derivatives of formula (1) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or anaplastic lymphoma kinase (ALK).
摘要翻译: 本发明提供式(1)的新型嘧啶衍生物及其药物组合物,以及使用这些化合物的方法。 例如,本发明的嘧啶衍生物可用于治疗,改善或预防对胰岛素样生长因子(IGF-1R)或间变性淋巴瘤激酶(ALK)的抑制作出反应的病症。
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