专利检索 ap:("Bang-Chi Chen" OR "Rulin Zhao" OR "Joseph Edward Sundeen" OR "Katerina Leftheris" OR "John Hynes" OR "Stephen T. Wrobleski") AND inv:"John Hynes" 第 1 页

1.

发明授权
Process for preparing pyrrolotriazine kinase inhibitors 失效
标题翻译：吡咯并三嗪激酶抑制剂的制备方法

公开(公告)号：US07034151B2

公开(公告)日：2006-04-25

申请号：US10773002

申请日：2004-02-05

申请人： Bang-Chi Chen , Rulin Zhao , Joseph Edward Sundeen , Katerina Leftheris , John Hynes , Stephen T. Wrobleski

发明人： Bang-Chi Chen , Rulin Zhao , Joseph Edward Sundeen , Katerina Leftheris , John Hynes , Stephen T. Wrobleski

IPC分类号： C07D487/04 , C07D253/07

CPC分类号： C07D487/04

摘要： An improved process for the preparation of certain pyrrolotriazine compounds is disclosed. The compounds exhibit utility as kinase inhibitors.

摘要翻译： 公开了制备某些吡咯并三嗪化合物的改进方法。这些化合物表现出作为激酶抑制剂的作用。

2.

发明申请
Process for preparing pyrrolotriazine kinase inhibitors 审中-公开

公开(公告)号：US20060041124A1

公开(公告)日：2006-02-23

申请号：US11250335

申请日：2005-10-14

申请人： Bang-Chi Chen , Rulin Zhao , Joseph Sundeen , Katerina Leftheris , John Hynes , Stephen Wrobleski

发明人： Bang-Chi Chen , Rulin Zhao , Joseph Sundeen , Katerina Leftheris , John Hynes , Stephen Wrobleski

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： An improved process for the preparation of certain pyrrolotriazine compounds is disclosed. The compounds exhibit utility as kinase inhibitors.

3.

发明授权
Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors 有权
标题翻译：用作激酶抑制剂的苯基苯胺取代的双环化合物

公开(公告)号：US07642257B2

公开(公告)日：2010-01-05

申请号：US12047550

申请日：2008-03-13

申请人： Jagabandhu Das , John Hynes , Katerina Leftheris , Shuqun Lin , Stephen T. Wrobleski , Hong Wu

发明人： Jagabandhu Das , John Hynes , Katerina Leftheris , Shuqun Lin , Stephen T. Wrobleski , Hong Wu

IPC分类号： C07D487/04 , A61K31/4985 , A61P19/02

CPC分类号： C07D471/04 , C07D487/04 , C07D495/04

摘要： Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.

摘要翻译： 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R，R1，R2，R5，R6a，R6b，J，K，X和Z如规范。

4.

发明授权
Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors 有权
标题翻译：用作激酶抑制剂的苯基苯胺取代的双环化合物

公开(公告)号：US07419978B2

公开(公告)日：2008-09-02

申请号：US10970420

申请日：2004-10-21

申请人： Jagabandhu Das , John Hynes , Katerina Leftheris , Shuqun Lin , Stephen T. Wrobleski , Hong Wu

发明人： Jagabandhu Das , John Hynes , Katerina Leftheris , Shuqun Lin , Stephen T. Wrobleski , Hong Wu

IPC分类号： C07D487/04 , C07D487/14 , A61K31/53 , A61P19/02 , A61P19/10

CPC分类号： C07D471/04 , C07D487/04 , C07D495/04

摘要： Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.

摘要翻译： 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R 1，R 2，R 2，R 2， R 5，R 6a，R 6b，J，K，X和Z如说明书中所述。

5.

发明授权
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors 失效
标题翻译：治疗p38激酶相关病症的方法和可用作激酶抑制剂的吡咯并三嗪化合物

公开(公告)号：US06670357B2

公开(公告)日：2003-12-30

申请号：US10036293

申请日：2001-11-07

申请人： Katerina Leftheris , John Hynes , Stephen T. Wrobleski , Joel Barrish

发明人： Katerina Leftheris , John Hynes , Stephen T. Wrobleski , Joel Barrish

IPC分类号： C07D48704

CPC分类号： C07D487/04 , C07D207/50

摘要： Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups —ZR4R5 taken together comprise an —NH-substituted aryl.

摘要翻译： 公开了治疗与p38激酶活性相关的一种或多种病症的方法，包括向有需要的患者施用至少一种具有式（I）的化合物或其药学上可接受的盐，前药或溶剂化物，其中R 3是氢，甲基，全氟甲基，甲氧基，卤素，氰基或NH 2，优选甲基，X，R 1至R 6和Z如说明书所述。有利的是基团-ZR 4 R 5一起包含-NH-取代的芳基。

6.

发明授权
Heterocyclic amide compounds useful as kinase inhibitors 有权
标题翻译：用作激酶抑制剂的杂环酰胺化合物

公开(公告)号：US08404689B2

公开(公告)日：2013-03-26

申请号：US13038488

申请日：2011-03-02

申请人： Stephen T. Wrobleski , Jagabandhu Das , T. G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin

发明人： Stephen T. Wrobleski , Jagabandhu Das , T. G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin

IPC分类号： A61K31/495 , A61K31/445 , A61K31/404 , C07D209/04 , C07D211/06 , C07D241/04

CPC分类号： C07D261/18 , C07C237/42 , C07C2601/02 , C07D207/456 , C07D209/08 , C07D209/42 , C07D211/62 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/90 , C07D235/06 , C07D249/06 , C07D271/06 , C07D271/10 , C07D275/03 , C07D295/192 , C07D307/68 , C07D333/38 , C07D409/04 , C07D487/04 , C07D513/04

摘要： A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.

摘要翻译： 式I化合物及其对映异构体，非对映异构体和药学上可接受的盐。还公开了含有式I化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

7.

发明授权
Heterocyclic amide compounds useful as kinase inhibitors 有权
标题翻译：用作激酶抑制剂的杂环酰胺化合物

公开(公告)号：US07935696B2

公开(公告)日：2011-05-03

申请号：US11923760

申请日：2007-10-25

申请人： Stephen T. Wrobleski , Jagabandhu Das , T. G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin

发明人： Stephen T. Wrobleski , Jagabandhu Das , T. G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin

IPC分类号： A61K31/5377 , A61K31/44 , A61K31/381 , C07D413/06 , C07D409/04 , C07D333/10

CPC分类号： C07D261/18 , C07C237/42 , C07C2601/02 , C07D207/456 , C07D209/08 , C07D209/42 , C07D211/62 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/90 , C07D235/06 , C07D249/06 , C07D271/06 , C07D271/10 , C07D275/03 , C07D295/192 , C07D307/68 , C07D333/38 , C07D409/04 , C07D487/04 , C07D513/04

摘要： A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.

摘要翻译： 式I化合物及其对映异构体，非对映异构体和药学上可接受的盐。还公开了含有式I化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

8.

发明授权
Pyrrolo-triazine aniline compounds useful as kinase inhibitors 有权

公开(公告)号：US07160883B2

公开(公告)日：2007-01-09

申请号：US10420399

申请日：2003-04-22

申请人： Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen T. Wrobleski

发明人： Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen T. Wrobleski

IPC分类号： C07D487/04 , C07D413/08 , A61K31/53 , A61K31/5377 , A61P19/02 , A61P19/04 , A61P9/10

CPC分类号： C07D487/04

摘要： Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.

9.

发明申请
HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权
标题翻译：杂环化合物作为激酶抑制剂有用

公开(公告)号：US20080171741A1

公开(公告)日：2008-07-17

申请号：US11923760

申请日：2007-10-25

申请人： Stephen T. Wrobleski , Jagabandhu Das , T.G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin

发明人： Stephen T. Wrobleski , Jagabandhu Das , T.G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin

IPC分类号： A61K31/5377 , C07D261/06 , C07D271/10 , C07D271/06 , C07D211/86 , C07D253/06 , C07D333/06 , C07D413/10 , A61P29/00 , C07D413/06 , A61K31/42 , A61K31/4245 , A61K31/4412 , A61K31/53 , A61K31/381

CPC分类号： C07D261/18 , C07C237/42 , C07C2601/02 , C07D207/456 , C07D209/08 , C07D209/42 , C07D211/62 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/90 , C07D235/06 , C07D249/06 , C07D271/06 , C07D271/10 , C07D275/03 , C07D295/192 , C07D307/68 , C07D333/38 , C07D409/04 , C07D487/04 , C07D513/04

摘要： A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.

摘要翻译： 式I化合物及其对映异构体，非对映异构体和药学上可接受的盐。还公开了含有式I化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

10.

发明申请
HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权
标题翻译：杂环化合物作为激酶抑制剂有用

公开(公告)号：US20110160207A1

公开(公告)日：2011-06-30

申请号：US13038488

申请日：2011-03-02

申请人： Stephen T. Wrobleski , Jagabandhu Das , T.G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin

发明人： Stephen T. Wrobleski , Jagabandhu Das , T.G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin

IPC分类号： A61K31/5377 , C07D261/18 , A61K31/42 , C07D271/10 , A61K31/4245 , C07D271/06 , C07D213/81 , A61K31/4412 , C07D487/04 , A61K31/53 , C07D513/04 , A61K31/519 , C07D233/90 , A61K31/4164 , C07D249/06 , A61K31/4192 , C07D403/12 , C07D295/195 , A61K31/495 , C07D211/62 , A61K31/445 , A61K31/407 , A61K31/44 , C07D333/38 , A61K31/381 , C07D413/14 , C07D409/04 , A61K31/4436 , C07D413/10 , C07D209/08 , C07D413/06 , A61P11/00 , A61P11/06 , A61P29/00 , A61P11/08 , A61P3/10 , A61P1/00 , A61P17/06 , A61P19/10 , A61P37/06 , A61P9/10 , A61P35/00 , A61P19/02

CPC分类号： C07D261/18 , C07C237/42 , C07C2601/02 , C07D207/456 , C07D209/08 , C07D209/42 , C07D211/62 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/90 , C07D235/06 , C07D249/06 , C07D271/06 , C07D271/10 , C07D275/03 , C07D295/192 , C07D307/68 , C07D333/38 , C07D409/04 , C07D487/04 , C07D513/04

摘要： A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.

摘要翻译： 式I化合物及其对映异构体，非对映异构体和药学上可接受的盐。还公开了含有式I化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

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