公开(公告)号：US20050075285A1

公开(公告)日：2005-04-07

申请号：US10467554

申请日：2002-02-07

申请人： Barbara Bour ,  John Chicca ,  Blake Denison ,  Frances Yen-Potin ,  Bernard Bihain ,  Stephane Bejanin ,  Hiroaki Tanaka ,  Severin Jobert ,  Jean-Yves Giordano ,  Jean-Baptiste Dumas Milne Edwards

发明人： Barbara Bour ,  John Chicca ,  Blake Denison ,  Frances Yen-Potin ,  Bernard Bihain ,  Stephane Bejanin ,  Hiroaki Tanaka ,  Severin Jobert ,  Jean-Yves Giordano ,  Jean-Baptiste Dumas Milne Edwards

IPC分类号： A61K38/00 ,  A61K38/10 ,  A61K38/08

CPC分类号： C07K14/5759 ,  A61K38/00 ,  C07K14/775 ,  Y10S514/909

摘要： The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. GSSP4 polypeptides have been identified that are believed to be beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing cholesterol levels, body mass, body fat, and for treating metabolic-related diseases and disorders. The metabolic-related diseases or disorders envisioned to be treated by the methods of the invention include, but are not limited to: obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, diabetes, glucose intolerance, insulin resistance and hypertension.

摘要翻译： 本发明涉及代谢研究领域。 代谢紊乱，如肥胖，是一个严重而广泛的公共卫生问题。 已经鉴定出GSSP4多肽被认为在治疗代谢紊乱中是有益的。 这些化合物应有效降低胆固醇水平，体重，体脂肪，以及治疗与代谢有关的疾病和病症。 预期通过本发明的方法治疗的代谢相关疾病或病症包括但不限于：肥胖症，高脂血症，高胆固醇血症，动脉粥样硬化，糖尿病，葡萄糖不耐受，胰岛素抵抗和高血压。

公开(公告)号：US07122644B2

公开(公告)日：2006-10-17

申请号：US10121034

申请日：2002-04-10

申请人： Frances Yen-Potin ,  Blake Denison ,  Aymeric Duclert ,  Lydie Bougueleret ,  Catherine Clusel ,  Jean-Baptiste Dumas Milne Edwards ,  Bernard Bihain ,  Barbara Bour ,  Dana Ebbets-Reed ,  Luisa Salter-Cid

发明人： Frances Yen-Potin ,  Blake Denison ,  Aymeric Duclert ,  Lydie Bougueleret ,  Catherine Clusel ,  Jean-Baptiste Dumas Milne Edwards ,  Bernard Bihain ,  Barbara Bour ,  Dana Ebbets-Reed ,  Luisa Salter-Cid

IPC分类号： C07H21/04

CPC分类号： C07K16/30 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4747 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/32 ,  C12N15/625

摘要： The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.

公开(公告)号：US20060189793A1

公开(公告)日：2006-08-24

申请号：US11412373

申请日：2006-04-27

申请人： Frances Yen ,  Blake Denison ,  Aymeric Duclert ,  Lydie Bougueleret ,  Catherine Clusel ,  Jean-Baptiste Dumas Milne-Edwards ,  Bernard Bihain ,  Barbara Bour ,  Dana Ebbets-Reed ,  Luisa Salter-Cid

发明人： Frances Yen ,  Blake Denison ,  Aymeric Duclert ,  Lydie Bougueleret ,  Catherine Clusel ,  Jean-Baptiste Dumas Milne-Edwards ,  Bernard Bihain ,  Barbara Bour ,  Dana Ebbets-Reed ,  Luisa Salter-Cid

IPC分类号： C07K16/30

CPC分类号： C07K16/30 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4747 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/32 ,  C12N15/625

摘要： The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptdes. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.

摘要翻译： 本发明提供GSSP-2，GSSP-2 cDNA和GSSP-2多肽的基因组序列。 此外，本发明提供了多核苷酸，其包括衍生自GSSP-2基因的双重标记和来自该基因侧翼的基因组区域。 本发明还提供适用于对含有本发明的一种或多种双重标记物的含有核酸分子的样品进行基因分型的多核苷酸和方法。 此外，本发明提供了检测双标记等位基因和表型之间和/或双重标记单倍型和表型之间的统计学相关性的方法。 本发明还涉及用于杀死肿瘤细胞或抑制肿瘤细胞生长的方法和组合物。 特别地，本发明涉及细胞增殖阻滞/抑制和凋亡/坏死诱导组合物和治疗肿瘤的方法。 本发明涉及新型多肽和编码那些多肽的核酸分子。

公开(公告)号：US20080199883A1

公开(公告)日：2008-08-21

申请号：US11693802

申请日：2007-03-30

申请人： Bernard Bihain ,  Barbara Bour ,  Lydie Bougueleret

发明人： Bernard Bihain ,  Barbara Bour ,  Lydie Bougueleret

IPC分类号： A01K67/027 ,  C07K14/00 ,  C07K16/00 ,  C12P21/00 ,  G01N33/53 ,  G01N33/566

CPC分类号： C07K14/47

摘要： The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns methods for the treatment or diagnosis of schizophrenia, bipolar disorder or related CNS disorder. The invention also concerns the interaction of PAPAP with schizophrenia candidate gene g34872.

摘要翻译： 本发明涉及PAPAP基因的多核苷酸，由PAPAP基因编码的多肽和针对这些多肽的抗体。 本发明还涉及治疗或诊断精神分裂症，双相情感障碍或相关CNS病症的方法。 本发明还涉及PAPAP与精神分裂症候选基因g34872的相互作用。

公开(公告)号：US07220581B2

公开(公告)日：2007-05-22

申请号：US10071645

申请日：2002-02-06

申请人： Bernard Bihain ,  Barbara Bour ,  Lydie Bougueleret

发明人： Bernard Bihain ,  Barbara Bour ,  Lydie Bougueleret

IPC分类号： C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N1/21 ,  C07K14/435

CPC分类号： C07K14/47

摘要： The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns methods for the treatment or diagnosis of schizophrenia, bipolar disorder or related CNS disorder. The invention also concerns the interaction of PAPAP with schizophrenia candidate gene g34872.

摘要翻译： 本发明涉及PAPAP基因的多核苷酸，由PAPAP基因编码的多肽，以及针对这些多肽的抗体。 本发明还涉及治疗或诊断精神分裂症，双相情感障碍或相关CNS病症的方法。 本发明还涉及PAPAP与精神分裂症候选基因g34872的相互作用。

公开(公告)号：US07449543B2

公开(公告)日：2008-11-11

申请号：US11693802

申请日：2007-03-30

申请人： Bernard Bihain ,  Barbara Bour ,  Lydie Bougueleret

发明人： Bernard Bihain ,  Barbara Bour ,  Lydie Bougueleret

IPC分类号： C07K14/00 ,  C07K14/435 ,  C12P21/00 ,  C07H21/04 ,  A61K38/06

CPC分类号： C07K14/47

摘要： The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns methods for the treatment or diagnosis of schizophrenia, bipolar disorder or related CNS disorder. The invention also concerns the interaction of PAPAP with schizophrenia candidate gene g34872.

摘要翻译： 本发明涉及PAPAP基因的多核苷酸，由PAPAP基因编码的多肽，以及针对这些多肽的抗体。 本发明还涉及治疗或诊断精神分裂症，双相情感障碍或相关CNS病症的方法。 本发明还涉及PAPAP与精神分裂症候选基因g34872的相互作用。