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    Preparation of alpha-hydroxyketones
    3.
    发明授权
    Preparation of alpha-hydroxyketones 有权
    α-羟基酮的制备

    公开(公告)号：US08575394B2

    公开(公告)日：2013-11-05

    申请号：US13557281

    申请日：2012-07-25

    申请人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    发明人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    IPC分类号： C07C225/00 ,  C07C223/00

    CPC分类号： C07F7/1892 ,  C07C45/30 ,  C07C45/58 ,  C07C49/82 ,  C07C49/83 ,  C07C49/747 ,  C07C49/84

    摘要： A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding α-hydroxyketone or α-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The α-hydroxyketones and α-aminoketones thus obtainable are useful inter alia as photoinitiators.

    摘要翻译： 公开了一种制备1,1-二取代的环氧乙烷的方法，其中有机硫化物在极性溶剂中与含有连接到伯或仲碳原子的离去基团的离子和/或在 在碱和极性溶剂的存在下，与酮反应。 所得类型的环氧乙烷可以通过在过渡金属催化剂存在下进行有氧氧化，或者在两步骤中在水溶液存在下进行水解，可以在一个步骤中进一步转化为相应的α-羟基酮或α-氨基酮 酸至相应的二醇并随后进行选择性氧化。 进一步描述了一些新型的环氧化物中间体。 因此可获得的α-羟基酮和α-氨基酮特别可用作光引发剂。

    PREPARATION OF ALPHA-HYDROXY AND ALPHA-AMINO KETONES
    4.
    发明申请
    PREPARATION OF ALPHA-HYDROXY AND ALPHA-AMINO KETONES 有权
    ALPHA-羟基和氨基 - 氨基酸的制备

    公开(公告)号：US20090018354A1

    公开(公告)日：2009-01-15

    申请号：US11631448

    申请日：2005-06-29

    申请人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    发明人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    IPC分类号： C07D301/02 ,  C07C49/00

    CPC分类号： C07F7/1892 ,  C07C45/30 ,  C07C45/58 ,  C07C49/82 ,  C07C49/83 ,  C07C49/747 ,  C07C49/84

    摘要： A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding α-hydroxyketone or α-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The α-hydroxyketones and α-aminoketones thus obtainable are useful inter alga as photoinitiators.

    摘要翻译： 公开了一种制备1,1-二取代的环氧乙烷的方法，其中有机硫化物在极性溶剂中与含有连接到伯或仲碳原子的离去基团的离子和/或在 在碱和极性溶剂的存在下，与酮反应。 所得类型的环氧乙烷可以通过在过渡金属催化剂存在下进行有氧氧化，或者在两步骤中在水溶液存在下进行水解，可以在一个步骤中进一步转化为相应的α-羟基酮或α-氨基酮 酸至相应的二醇并随后进行选择性氧化。 进一步描述了一些新型的环氧化物中间体。 因此获得的α-羟基酮和α-氨基酮可以作为光引发剂是有效的藻类。

    Isoxazoline derivatives as P N ligands
    5.
    发明授权
    Isoxazoline derivatives as P N ligands 失效
    异恶唑啉衍生物作为P N配体

    公开(公告)号：US07081536B2

    公开(公告)日：2006-07-25

    申请号：US10485839

    申请日：2002-08-01

    申请人： Nicole End ,  Catherine Stoessel ,  Ulrich Berens ,  Pier Giorgio Cozzi

    发明人： Nicole End ,  Catherine Stoessel ,  Ulrich Berens ,  Pier Giorgio Cozzi

    IPC分类号： C07D263/08

    CPC分类号： C07F15/065 ,  C07C29/143 ,  C07C45/29 ,  C07F9/65583 ,  C07F9/65586 ,  C07F15/004 ,  C07F15/0053 ,  C07F15/0066 ,  C07F15/008 ,  C07F15/0093 ,  C07F15/045 ,  C07C33/22

    摘要： The invention relates to novel ligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of formula I and mixtures of such compounds, wherein X is oxygen, sulfur, selenium or NQ, wherein Q is unsubstituted or substituted aryl, or alkyl or substituted alkyl; n is 0, 1, 2, 3 or 4; A1 and A2 are each an organic radical capable of bonding to phosphorus, especially unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted cycloalkyl, or —N(D)2 wherein D2 is alkyl or substituted alkyl; or A1 and A2 together with the bonding phosphorus atom form a ring, which may be unsubstituted or substituted; Y, Y′, Y″ and Y′″ are each independently of the other hydrogen or alkyl, substituted alkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heterocyclyl, at least one of the radicals Y, Y′, Y″ or Y′″ being one of the mentioned radicals with the exception of hydrogen; and Z, when present, is a substituent, it being possible when a plurality of substituents Z is present for those substituents to be selected independently of one another, and to processes for their preparation, to novel precursors and intermediates, to complexes with the said ligands, to their preparation and to their use as catalysts in organic synthesis (especially asymmetric organic synthesis).

    摘要翻译： 本发明涉及膦酰基苯并噻吩基 - 二氢恶唑啉，膦基 - 二氢恶唑基 - 吲哚和膦基 - 二氢恶唑基 - 苯并呋喃型的新配体，特别是式I化合物及其混合物，其中X是氧，硫，硒或NQ，其中Q是 未取代或取代的芳基，或烷基或取代的烷基; n为0,1,2,3或4; A 1和A 2分别是能够与磷结合的有机基团，特别是未取代或取代的烷基，未取代或取代的芳基，未取代或取代的杂环基，未取代或取代的环烷基 或-N（D）2，其中D 2是烷基或取代的烷基; 或A 1和A 2与键合磷原子一起形成环，其可以是未取代的或取代的; Y，Y'，Y“和Y”'各自独立地为另一个氢或烷基，取代的烷基，未取代或取代的芳基，或未取代或取代的杂环基，基团Y，Y'，Y' '或Y''是除了氢之外的所提及的基团之一; 当存在时，Z是一个取代基，当对于那些彼此独立选择的那些取代基存在多个取代基Z，并且其制备方法，新的前体和中间体与所述的 配体，它们的制备和用作有机合成（特别是不对称有机合成）中的催化剂。

    Preparation of α-hydroxy and α-amino ketones
    9.
    发明授权
    Preparation of α-hydroxy and α-amino ketones 有权
    α-羟基和α-氨基酮的制备

    公开(公告)号：US08252959B2

    公开(公告)日：2012-08-28

    申请号：US11631448

    申请日：2005-06-29

    申请人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    发明人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    IPC分类号： C07C49/00 ,  C07C45/00 ,  C07D301/24

    CPC分类号： C07F7/1892 ,  C07C45/30 ,  C07C45/58 ,  C07C49/82 ,  C07C49/83 ,  C07C49/747 ,  C07C49/84

    摘要： A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding α-hydroxyketone or α-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The α-hydroxyketones and α-aminoketones thus obtainable are useful inter alga as photoinitiators.

    摘要翻译： 公开了一种制备1,1-二取代的环氧乙烷的方法，其中有机硫化物在极性溶剂中与含有连接到伯或仲碳原子的离去基团的离子和/或在 在碱和极性溶剂的存在下，与酮反应。 所得类型的环氧乙烷可以通过在过渡金属催化剂的存在下进行好氧氧化，或者在水溶液存在下通过水解两步在一个步骤中进一步转化为相应的α-羟基酮或α-氨基酮 酸至相应的二醇并随后进行选择性氧化。 进一步描述了一些新型的环氧化物中间体。 因此获得的α-羟基酮和α-氨基酮可以作为光引发剂是有效的藻类。