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公开(公告)号：US10526314B2
公开(公告)日：2020-01-07
申请号：US16098202
申请日：2017-05-02
Applicant: BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Hanna Tinel , Heiko Schirmer
IPC: C07D401/14 , C07D403/14 , C07D417/14 , A61P9/10 , A61P9/12 , A61P13/12 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06
Abstract: The present invention relates to novel 5-(hydroxyalkyl)-1-heteroaryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US11319324B2
公开(公告)日：2022-05-03
申请号：US16759262
申请日：2018-10-18
Applicant: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
Inventor： Marcus Koppitz , Holger Siebeneicher , Nico Bräuer , Elisabeth Pook , Andrea Rotgeri , Roland Neuhaus , Oliver Martin Fischer , Jens Nagel , Adam James Davenport , James Lindsay Carr , Robert James Townsend , Nina Connelly Ursinyova , Shelley Anne Parrott
IPC: C07D487/14
Abstract: The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11298367B2
公开(公告)日：2022-04-12
申请号：US16758742
申请日：2018-10-17
Applicant: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
Inventor： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Hana Cernecka , Karoline Droebner , Hanna Tinel , Anja Buchmueller , Thomas Mondritzki , Axel Kretschmer , Klemens Lustig , Robert Fricke , Guillaume Levilain , Ursula Krenz , Norbert Witowski
IPC: A61K31/675 , A61P13/12 , A61K45/06 , C07F9/6558
Abstract: The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US11173151B2
公开(公告)日：2021-11-16
申请号：US16756623
申请日：2018-10-17
Applicant: BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Hanna Tinel , Niels Lindner , Heiko Schirmer
IPC: A61K31/4439 , A61K31/4188 , A61K31/4196 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/10
Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10472348B2
公开(公告)日：2019-11-12
申请号：US15969222
申请日：2018-05-02
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC: A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US11230540B2
公开(公告)日：2022-01-25
申请号：US16758744
申请日：2018-10-17
Applicant: Bayer Pharma Aktiengesellschaft
Inventor： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Hanna Tinel , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Klemens Lustig
IPC: C07D403/14 , A61P9/10 , A61K45/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14
Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US11149023B2
公开(公告)日：2021-10-19
申请号：US16758345
申请日：2018-10-17
Applicant: Bayer Pharma Aktiengesellschaft
Inventor： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Heiko Schirmer , Hanna Tinel
IPC: C07D401/14 , A61K45/06
Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10927098B2
公开(公告)日：2021-02-23
申请号：US16343150
申请日：2017-10-16
Applicant: Bayer Pharma Aktiengesellschaft
Inventor： Chantal Fuerstner , Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Elisabeth Pook , Heiko Schirmer , Carsten Schmeck , Pierre Wasnaire , Matthias Beat Wittwer
IPC: C07D403/06 , A61P13/12 , C07D403/14
Abstract: The present invention relates to novel 3-(hydroxyalkyl)-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and/or cardiovascular diseases.
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公开(公告)号：US09988367B2
公开(公告)日：2018-06-05
申请号：US15581064
申请日：2017-04-28
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC: A61K31/4439 , C07D401/14 , A61K45/06
CPC classification number: C07D401/14 , A61K31/4439 , A61K45/06
Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10525041B2
公开(公告)日：2020-01-07
申请号：US16098255
申请日：2017-05-02
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Thomas Neubauer , Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer
IPC: A61K31/4196 , C07D403/06 , A61P9/10 , A61P13/12 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D405/14 , C07D249/12
Abstract: The present invention relates to novel 5-(fluoroalkyl)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
