Device used in parallel microsynthesis
    1.
    发明授权
    Device used in parallel microsynthesis 有权
    平行微合成中使用的装置

    公开(公告)号:US07132081B2

    公开(公告)日:2006-11-07

    申请号:US10296056

    申请日:2001-04-27

    IPC分类号: B01L3/00

    摘要: Microwells, which are open on both sides and are arranged two-dimensionally in a microwell matrix (4), are hermetically closed by pressure on both sides using plugs (6) covered with a sealing sheet (11). A layer of elastic material (9), which is arranged between the plug (6) and the sealing sheet (11), guarantees uniform pressure on all the microwells of a microwell matrix (4) which is loosely held by a frame structure (1). Continuous peripheral elevations (2), which protrude in both directions at right angles to the plane of the microwell matrix (4), ensure that the deformable thin layer of elastic material (9) does not escape sideways between the plug (6) and the microwell matrix (4) during the pressing process. A plurality of microwell matrices (4) are held simultaneously by the frame structure (1) and are hermetically closed by a corresponding number of allocated plugs (6), which are fastened to a base plate (7) and a cover plate (8), respectively.

    摘要翻译: 在两侧开口并且在微孔矩阵(4)中二维布置的微孔通过用密封片(11)覆盖的塞子(6)在两侧通过压力气密封闭。 布置在塞子(6)和密封片(11)之间的一层弹性材料(9)保证了均匀的压力,所述的微孔基体(4)的所有微孔被框架结构(1)松动地保持 )。 在与微孔矩阵(4)的平面成直角的两个方向上突出的连续周边高度(2)确保弹性材料(9)的可变形薄层不会在插头(6)和 微孔基质(4)。 多个微孔矩阵(4)由框架结构(1)同时保持,并被相应数量的分配的塞子(6)气密地封闭,该插头固定到基板(7)和盖板(8)上, , 分别。

    Sampling device for a microreaction system
    2.
    发明申请
    Sampling device for a microreaction system 审中-公开
    微反应系统采样装置

    公开(公告)号:US20070110629A1

    公开(公告)日:2007-05-17

    申请号:US10563241

    申请日:2004-06-05

    IPC分类号: B01L3/02

    摘要: The invention relates to a sampling device (1) for a microreaction system (3), comprising an outlet (4) and a suction line opening (9) which is arranged next to the outlet (4). A depression can be produced in the suction line (9) for the suction of the substances (13) leaving the outlet (4). The outlet (4) is embodied as a capillary and can be positioned in relation to the opening of the suction line (9). The outlet (4) is surrounded by a housing (6) comprising a discharge outlet (14) for the substances (13) leaving the outlet (4), and a through-opening (8) for the suction line (9). Said suction line (9) opens up into a collecting tank (10) that is connected to a vacuum line (12) by means of an electrovalve (1).

    摘要翻译: 本发明涉及一种用于微反应系统(3)的采样装置(1),其包括邻近出口(4)布置的出口(4)和吸入管路开口(9)。 可以在吸入管线(9)中产生用于抽出离开出口(4)的物质(13)的凹陷。 出口(4)被实施为毛细管并且可以相对于吸入管线(9)的开口定位。 出口(4)由包括用于离开出口(4)的物质(13)的排出口(14)和用于吸入管线(9)的通孔(8))的壳体(6)围绕。 所述吸入管线(9)通过电阀(1)打开到与真空管线(12)连接的收集罐(10)中。

    Adhesion receptor antagonists III
    10.
    发明授权
    Adhesion receptor antagonists III 失效
    粘附受体拮抗剂III

    公开(公告)号:US5561148A

    公开(公告)日:1996-10-01

    申请号:US310085

    申请日:1994-09-22

    摘要: Novel oxazolidinone derivatives of the formula I ##STR1## in which R.sup.1 is a phenyl radical which is unsubstituted or is monosubstituted by CN, H.sub.2 N--CH.sub.2 --, A.sub.2 N--CH.sub.2 --, H.sub.2 N--C(.dbd.NH)--, H.sub.2 N--C(.dbd.NH)--NH--, H.sub.2 N--C(.dbd.NH)--NH--CH.sub.2 --, HO--NH--C(.dbd.NH)-- or HO--NH--C(.dbd.NH)--NH--,X is O, S, SO, SO.sub.2, --NH-- or --NA--,B is ##STR2## or ##STR3## A is alkyl having from 1 to 6 C atoms,R.sup.2 is H, A, Li, Na, K, NH.sub.4 or benzyl,R.sup.3 is H or (CH.sub.2).sub.n --COOR.sup.2,E is, in each case independently of each other, CH or N,Q is O, S or NH,m is 1, 2 or 3, andn is 0, 1, 2 or 3,and physiologically compatible salts thereof are provided, which inhibit the binding of fibrinogen to the corresponding receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and also tumors.

    摘要翻译: 式I的新型恶唑烷酮衍生物,其中R 1是未取代的或被CN,H 2 N-CH 2 - ,A 2 N-CH 2 - ,H 2 N-C(= NH) - ,H 2 N-C(= = NH)-NH-,H 2 N-C(= NH)-NH-CH 2 - ,HO-NH-C(= NH) - 或HO-NH-C(= NH)-NH-,X为O, SO,SO 2,-NH-或-NA-,B为或A为具有1至6个C原子的烷基,R 2为H,A,Li,Na,K,NH 4或苄基,R 3为 H或(CH 2)n -COOR 2,E各自独立地为CH或N,Q为O,S或NH,m为1,2或3,n为0,1,2或3 和其生理上相容的盐,其抑制纤维蛋白原与相应受体的结合,并且可用于治疗血栓形成,中风,心肌梗塞,炎症,动脉硬化,骨质疏松症以及肿瘤。