公开(公告)号：US07108707B2

公开(公告)日：2006-09-19

申请号：US10600817

申请日：2003-06-20

申请人： Benjamin C. Huter ,  Kevin M. Magrini ,  John E. Papp

发明人： Benjamin C. Huter ,  Kevin M. Magrini ,  John E. Papp

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A filtering device for capturing and removing embolic debris from a body vessel and a system for insertion and removal of the filtering device to facilitate an interventional procedure in a stenosed or occluded region of a body vessel. The filtering device is adapted to be expandable in the body vessel, allowing blood to pass therethrough while maintaining apposition with the body vessel wall and capturing embolic material released into the bloodstream during the interventional procedure, and to be collapsible to remove the captured embolic material from the body vessel. The filtering device includes a guide wire, an expandable cage assembly secured to the guide wire, filter material secured to the expandable cage assembly, and at least one hinge, the hinge allowing the expandable cage assembly to bend independent from the guide wire. The system, which includes a delivery sheath and filtering device, is adapted to retain the expandable cage assembly in a collapsed condition and deliver and deploy the filtering device at a location in the body vessel distal the treatment site.

公开(公告)号：US06592606B2

公开(公告)日：2003-07-15

申请号：US09944633

申请日：2001-08-31

申请人： Benjamin C. Huter ,  Kevin M. Magrini ,  John E. Papp

发明人： Benjamin C. Huter ,  Kevin M. Magrini ,  John E. Papp

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A filtering device for capturing and removing embolic debris from a body vessel and a system for insertion and removal of the filtering device to facilitate an interventional procedure in a stenosed or occluded region of a body vessel. The filtering device is adapted to be expandable in the body vessel, allowing blood to pass therethrough while maintaining apposition with the body vessel wall and capturing embolic material released into the bloodstream during the interventional procedure, and to be collapsible to remove the captured embolic material from the body vessel. The filtering device includes a guide wire, an expandable cage assembly secured to the guide wire, filter material secured to the expandable cage assembly, and at least one hinge, the hinge allowing the expandable cage assembly to bend independent from the guide wire. The system, which includes a delivery sheath and filtering device, is adapted to retain the expandable cage assembly in a collapsed condition and deliver and deploy the filtering device at a location in the body vessel distal the treatment site.

摘要翻译： 一种用于从身体容器捕获和去除栓塞碎片的过滤装置，以及用于插入和移除过滤装置的系统，以便于在体内容器的狭窄或阻塞区域进行介入手术。 过滤装置适于在身体容器中扩张，允许血液通过其中，同时保持与身体血管壁的配合并且在介入手术过程中捕获释放到血流中的栓塞物质，并且可收缩以将捕获的栓塞材料从 身体血管。 过滤装置包括引导线，固定到引导线的可膨胀保持架组件，固定到可膨胀保持架组件的过滤材料以及至少一个铰链，铰链允许可膨胀笼组件独立于导丝弯曲。 包括输送护套和过滤装置的系统适于将可膨胀笼组件保持在折叠状态，并将过滤装置输送并部署在远离治疗部位的体内血管的位置。

公开(公告)号：US07842064B2

公开(公告)日：2010-11-30

申请号：US11496854

申请日：2006-08-01

申请人： Benjamin C. Huter ,  Kevin M. Magrini ,  John E. Papp

发明人： Benjamin C. Huter ,  Kevin M. Magrini ,  John E. Papp

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A filtering device for capturing and removing embolic debris from a body vessel and a system for insertion and removal of the filtering device to facilitate an interventional procedure in a stenosed or occluded region of a body vessel. The filtering device is adapted to be expandable in the body vessel, allowing blood to pass therethrough while maintaining apposition with the body vessel wall and capturing embolic material released into the bloodstream during the interventional procedure, and to be collapsible to remove the captured embolic material from the body vessel. The filtering device includes a guidewire, an expandable cage assembly secured to the guide wire, filter material secured to the expandable cage assembly, and at least one hinge, the hinge allowing the expandable cage assembly to bend independent from the guide wire. The system, which includes a delivery sheath and filtering device, is adapted to retain the expandable cage assembly in a collapsed condition and deliver and deploy the filtering device at a location in the body vessel distal the treatment site.

摘要翻译： 一种用于从身体容器捕获和去除栓塞碎片的过滤装置，以及用于插入和移除过滤装置的系统，以便于在体内容器的狭窄或阻塞区域进行介入手术。 过滤装置适于在身体容器中扩张，允许血液通过其中，同时保持与身体血管壁的配合并且在介入手术过程中捕获释放到血流中的栓塞物质，并且可收缩以将捕获的栓塞材料从 身体血管。 过滤装置包括导丝，固定到导丝的可膨胀保持架组件，固定到可膨胀笼组件的过滤材料以及至少一个铰链，该铰链允许可膨胀笼组件独立于导丝弯曲。 包括输送护套和过滤装置的系统适于将可膨胀笼组件保持在折叠状态，并将过滤装置输送并部署在远离治疗部位的体内血管的位置。

公开(公告)号：US07252675B2

公开(公告)日：2007-08-07

申请号：US10260710

申请日：2002-09-30

申请人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

发明人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.

摘要翻译： 用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架 第二控制臂通过部分回路。 部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。 可以改变每个半框架的第一和第二控制臂的长度和定位，以便产生符合过滤装置展开的身体容器的尺寸和形状的可扩张框架。 此外，部分回路的半径以及部分回路的圆弧的长度可以在每个框架上变化以产生可以容易地适应身体血管的尺寸和形状的复合过滤组件。 此外，半框架的控制臂可以在复合环路的近侧或远端设置，以产生不同的过滤结构。

公开(公告)号：US07241304B2

公开(公告)日：2007-07-10

申请号：US10027915

申请日：2001-12-21

申请人： William J. Boyle ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp

发明人： William J. Boyle ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/008

摘要： A self-expanding cage for use in conjunction with an embolic filtering device includes one or more circumferential members adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. At least one proximal strut and at least one distal strut are attached to the circumferential member to form the basket. The circumferential member may include a plurality of bending regions which enhance the ability of the circumferential member to move between the unexpanded and expanded positions. The proximal and distal struts can be attached to one of the bending regions. When two or more circumferential members are utilized, each member may be connected by a connecting strut which may be connected at a bending region. The connecting strut can be a straight segment or may have a non-linear shape to provide additional flexibility. The expandable cage can be mounted to a elongated member, such as a guide wire, and can be either permanently mounted or rotatably mounted thereto.

摘要翻译： 用于与栓塞过滤装置结合使用的自膨胀笼包括适于从未膨胀位置扩展到患者体内容器内的扩张位置的一个或多个周向构件。 至少一个近端支柱和至少一个远端支柱附接到周向构件以形成篮。 周向构件可以包括多个弯曲区域，这些弯曲区域增强了圆周构件在未膨胀和膨胀位置之间移动的能力。 近端和远端支柱可以附接到一个弯曲区域。 当使用两个或更多个周向构件时，每个构件可以通过可在弯曲区域处连接的连接支柱连接。 连接支柱可以是直线段，或者可以具有非线性形状以提供额外的灵活性。 可扩展的保持架可以安装到诸如导丝的细长构件上，并且可以永久地安装或可旋转地安装在其上。

公开(公告)号：US08029530B2

公开(公告)日：2011-10-04

申请号：US12904001

申请日：2010-10-13

申请人： Douglas H. Gesswein ,  Wayne E. Cornish ,  Scott J. Huter ,  Benjamin C. Huter ,  John E. Papp

发明人： Douglas H. Gesswein ,  Wayne E. Cornish ,  Scott J. Huter ,  Benjamin C. Huter ,  John E. Papp

IPC分类号： A61F2/01

CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/008

摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.

摘要翻译： 一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时 步骤。 该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。 导丝连接器能够与导丝的螺旋线圈耦合。 以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。 或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。 这种布置允许过滤器组件可旋转地安装在导丝上。

公开(公告)号：US07976560B2

公开(公告)日：2011-07-12

申请号：US11654426

申请日：2007-01-17

申请人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

发明人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.

摘要翻译： 用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架 第二控制臂通过部分回路。 部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。 可以改变每个半框架的第一和第二控制臂的长度和定位，以便产生符合过滤装置展开的身体容器的尺寸和形状的可扩张框架。 此外，部分回路的半径以及部分回路的圆弧的长度可以在每个框架上变化以产生可以容易地适应身体血管的尺寸和形状的复合过滤组件。 此外，半框架的控制臂可以在复合环路的近侧或远端设置，以产生不同的过滤结构。

公开(公告)号：US07678128B2

公开(公告)日：2010-03-16

申请号：US09897295

申请日：2001-06-29

申请人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

发明人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.

摘要翻译： 部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。 部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。 用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。 在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。 恢复护套可以在内导管上推进以使可膨胀过滤器折叠。 内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

公开(公告)号：US08672991B2

公开(公告)日：2014-03-18

申请号：US12724140

申请日：2010-03-15

申请人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

发明人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

IPC分类号： A61F2/06

CPC分类号： A61F2/013 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.

摘要翻译： 部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。 部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。 用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。 在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。 恢复护套可以在内导管上推进以使可膨胀过滤器折叠。 内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

公开(公告)号：US07959646B2

公开(公告)日：2011-06-14

申请号：US11768685

申请日：2007-06-26

申请人： Benjamin C. Huter ,  John E. Papp ,  Anuja Patel ,  John D. Whitfield

发明人： Benjamin C. Huter ,  John E. Papp ,  Anuja Patel ,  John D. Whitfield

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/008

摘要： A system for enabling the insertion and removal of an embolic protection device, for capturing and retaining embolic debris which may be created during the performance of a therapeutic interventional procedure in a stenosed or occluded region of a blood vessel. The system, in an embodiment thereof, enables the device to be snap-fitted so as to engage the distal end of a guide wire, to provide a reference for positioning the device at a location distal to the interventional procedure site, and to enable an end of the device to be in tension, enabling a portion of the device to be in tension and another portion to be in compression, so as to assist in bending thereof in tortuous vasculature.

摘要翻译： 一种能够插入和移除栓塞保护装置的系统，用于捕获和保留在血管的狭窄或阻塞区域中执行治疗介入手术期间可产生的栓塞碎片。 该系统在其一个实施例中使得装置能够被卡扣配合以便与导丝的远端接合，以提供用于将装置定位在远离介入手术部位的位置处的参考，并使得能够 所述装置的端部处于张紧状态，使得所述装置的一部分处于张紧位置，另一部分被压缩，从而有助于弯曲弯曲的脉管系统。