公开(公告)号：US20080176811A1

公开(公告)日：2008-07-24

申请号：US12057425

申请日：2008-03-28

申请人： Bernadette Geers ,  Ralf Otto ,  Albrecht Weiss ,  Dirk Petersohn ,  Klaus Rudolf Schroeder ,  Kordula Schlotmann

发明人： Bernadette Geers ,  Ralf Otto ,  Albrecht Weiss ,  Dirk Petersohn ,  Klaus Rudolf Schroeder ,  Kordula Schlotmann

IPC分类号： A61K31/7048 ,  C07H17/06 ,  C12P19/60 ,  A61P17/00 ,  A61Q19/02

CPC分类号： A61K8/602 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/73 ,  A61Q19/02 ,  C07H17/07 ,  C12P7/62 ,  C12P17/06 ,  C12P19/60 ,  A23V2250/2116 ,  A23V2250/1866

摘要： Substituted and unsubstituted flavone or isoflavone glycoside derivatives of the formula [A1-C(═O)O]m—[X—O-Z]—[O—C(═O)-A2]n, wherein [X—O-Z] represents a flavone or isoflavone glycoside structure, particularly a naringin residue, X is a flavone or isoflavone corresponding to formula (IIa) or formula (IIb): wherein the flavone or isoflavone residue is substituted one or more times and/or reduced one or more times; Z represents a mono-, di- or polysaccharide, which is acetally-bound at the benzopyran group to X and ester-substituted by —O—C(═O)-A2; [A1-C(═O)] is an acyl group on the flavone or isoflavone; A1 and A2 independently, represent a polyunsaturated C15-26 alkenyl group containing at least four isolated and/or at least two conjugated double bonds, or an arylaliphatic radical with 1-to-4 methylene groups between the ester group and the aromatic ring; [C(═O)A2] is an acyl group; n is an integer other than 0; m is an integer, including 0; and R1, R2 and R are hydroxyl groups or hydrogen atoms.

摘要翻译： 取代和未取代的式[A-1-C（-O）O] - [XOZ] - [OC（-O）-A）的黄酮或异黄酮糖苷衍生物 其中[XOZ]表示黄酮或异黄酮糖苷结构，特别是柚皮苷残基，X是与式（IIa）或式（IIa）相应的黄酮或异黄酮 IIb）：其中所述黄酮或异黄酮残基被一次或多次取代和/或还原一次或多次; Z表示一种，二或多糖，其在苯并吡喃基团处与X缩合而X和被-O-C（-O）-A 2 - 被酯取代。 [A-1] -C（-O）]是黄酮或异黄酮上的酰基; A 1和A 2独立地表示含有至少四个分离和/或至少两个共轭双键的多不饱和C 15-26亚烯基 或在酯基和芳香环之间具有1至4个亚甲基的芳基脂族基; [C（-O）A 2]是酰基; n是0以外的整数; m是整数，包括0; 并且R 1，R 2和R 2是羟基或氢原子。