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公开(公告)号：US07825277B2
公开(公告)日：2010-11-02
申请号：US11801385
申请日：2007-05-09
申请人： Bernhard Gutsche , Stefan Franzen , Markus Kloeker
发明人： Bernhard Gutsche , Stefan Franzen , Markus Kloeker
CPC分类号： C07B41/08 , C07C51/34 , C07C55/18 , C07C53/126
摘要： A process for the ozonolysis of unsaturated starting materials, which is characterized in that the reaction is carried out in a structured reactor.
摘要翻译： 一种不饱和原料的臭氧分解方法，其特征在于反应在结构化的反应器中进行。
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公开(公告)号：US20070276165A1
公开(公告)日：2007-11-29
申请号：US11801385
申请日：2007-05-09
申请人： Bernhard Gutsche , Stefan Franzen , Markus Kloeker
发明人： Bernhard Gutsche , Stefan Franzen , Markus Kloeker
IPC分类号： C07C27/00
CPC分类号： C07B41/08 , C07C51/34 , C07C55/18 , C07C53/126
摘要： A process for the ozonolysis of unsaturated starting materials, which is characterized in that the reaction is carried out in a structured reactor.
摘要翻译： 一种不饱和原料的臭氧分解方法，其特征在于反应在结构化的反应器中进行。
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公开(公告)号：US08674146B2
公开(公告)日：2014-03-18
申请号：US12440461
申请日：2007-08-29
CPC分类号： C07C41/02 , B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , C07C41/03 , C07C213/04 , C08G65/2696 , C11D1/44 , C11D1/72 , C11D1/74 , C07C43/11
摘要： The invention relates to a method for producing alkylene oxide addition products by reaction of compounds having a nucleophilic center with alkylene oxides in a reactor having a large inner surface. The invention is characterized in that the reaction is carried out exclusively in the liquid phase.
摘要翻译： 本发明涉及通过在具有大内表面的反应器中使具有亲核中心的化合物与烯化氧反应制备环氧烷加成产物的方法。 本发明的特征在于反应仅在液相中进行。
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公开(公告)号：US20110218349A1
公开(公告)日：2011-09-08
申请号：US12440459
申请日：2007-08-29
申请人： Stefan Franzen , Bernhard Gutsche , Bernd Fabry , Eik Ulf Mahnke
发明人： Stefan Franzen , Bernhard Gutsche , Bernd Fabry , Eik Ulf Mahnke
IPC分类号： C07D301/10
CPC分类号： C07C41/03 , C07D301/10 , C08G65/2603 , C08G65/2609 , C08G65/2696 , C07C43/11
摘要： The invention relates to a method for producing alkylene oxide addition products. The method according to the invention is characterized by (a) contacting ethylene and/or propylene with an oxidizing agent in a first structured reactor (“μ reactor”) and (b) feeding the ethylene oxide and/or propylene oxide so obtained, optionally after purification, to a second structured reactor where it is reacted with a compound having a nucleophilic molecular group.
摘要翻译： 本发明涉及一种生产环氧烷加成产物的方法。 根据本发明的方法的特征在于：（a）在第一结构化反应器（“μ反应器”）中将乙烯和/或丙烯与氧化剂接触，和（b）将如此获得的环氧乙烷和/或环氧丙烷 纯化后的第二结构反应器与其具有亲核分子基团的化合物反应。
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公开(公告)号：US07943790B2
公开(公告)日：2011-05-17
申请号：US12295679
申请日：2007-03-23
申请人： Bernhard Gutsche , Bernd Fabry , Stefan Franzen
发明人： Bernhard Gutsche , Bernd Fabry , Stefan Franzen
IPC分类号： C07D303/00 , C07D301/12
CPC分类号： C07D301/12 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , C07D301/14
摘要： The invention provides a process for preparing alkene oxides by contacting in a microreaction system (μ-reactor) a C2- C3 alkene with an oxidizing agent comprising a peroxo compound.
摘要翻译： 本发明提供了一种通过使C 2 -C 3烯与包含过氧化合物的氧化剂的微反应系统（μ-反应器）接触来制备烯烃的方法。
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公开(公告)号：US20090253944A1
公开(公告)日：2009-10-08
申请号：US12295679
申请日：2007-03-23
申请人： Bernhard Gutsche , Bernd Fabry , Stefan Franzen
发明人： Bernhard Gutsche , Bernd Fabry , Stefan Franzen
IPC分类号： C07C29/04
CPC分类号： C07D301/12 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , C07D301/14
摘要： The invention provides a process for preparing ethylene oxide and/or propylene oxide by contacting ethylene and/or propylene with an oxidizing agent, wherein (i) the reaction takes place in a microreaction system (p-reactor) and (ii) the oxidizing agent used is a peroxo compound.
摘要翻译： 本发明提供了通过使乙烯和/或丙烯与氧化剂接触来制备环氧乙烷和/或环氧丙烷的方法，其中（i）反应在微反应系统（p反应器）中进行，和（ii）氧化剂 使用过氧化合物。
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公开(公告)号：US20100041923A1
公开(公告)日：2010-02-18
申请号：US12440461
申请日：2007-08-29
IPC分类号： C07C41/02
CPC分类号： C07C41/02 , B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , C07C41/03 , C07C213/04 , C08G65/2696 , C11D1/44 , C11D1/72 , C11D1/74 , C07C43/11
摘要： The invention relates to a method for producing alkylene oxide addition products by reaction of compounds having a nucleophilic center with alkylene oxides in a reactor having a large inner surface. The invention is characterized in that the reaction is carried out exclusively in the liquid phase.
摘要翻译： 本发明涉及通过在具有大内表面的反应器中使具有亲核中心的化合物与烯化氧反应制备环氧烷加成产物的方法。 本发明的特征在于反应仅在液相中进行。
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公开(公告)号：US09061076B2
公开(公告)日：2015-06-23
申请号：US12601736
申请日：2008-05-22
申请人： Stefan Franzen , Richard Guenther , Steven A. Lommel , LiNa Loo
发明人： Stefan Franzen , Richard Guenther , Steven A. Lommel , LiNa Loo
CPC分类号： A61K47/48776 , A61K9/5184 , A61K47/6425 , A61K47/645 , A61K47/6901 , B82Y5/00 , C12N7/00 , C12N15/09 , C12N2770/38023 , C12N2770/38043 , C12N2799/02 , C12N2810/855
摘要： This invention is a process for the manufacture of a plant viral capsid to be used for the targeted delivery of therapeutics to diseased cells. The process uses a plant virus as the starting material. The choice of the plant virus overcomes a problem in the manufacture of a uniform starting material. The final product has an advantage over other plant virus-based delivery systems in that the plant virus selected has a natural structure that is resistant to breakdown during the delivery process. This system takes advantage of the reversible divalent cation switch that this capsid employs to assemble and disassemble.
摘要翻译： 本发明是一种用于制造用于向病变细胞靶向递送治疗剂的植物病毒衣壳的方法。 该过程使用植物病毒作为起始材料。 植物病毒的选择克服了制造均匀原料的问题。 最终产品优于其他基于植物病毒的递送系统，因为所选择的植物病毒具有在递送过程中耐破坏的天然结构。 该系统利用该衣壳用于组装和拆卸的可逆二价阳离子开关。
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公开(公告)号：US20120039799A1
公开(公告)日：2012-02-16
申请号：US12601736
申请日：2008-05-22
申请人： Stefan Franzen , Richard Guenther , Steven A. Lommel , LiNa Loo
发明人： Stefan Franzen , Richard Guenther , Steven A. Lommel , LiNa Loo
IPC分类号： A61K9/00 , A61K31/704 , A61P35/00 , A61K51/00
CPC分类号： A61K47/48776 , A61K9/5184 , A61K47/6425 , A61K47/645 , A61K47/6901 , B82Y5/00 , C12N7/00 , C12N15/09 , C12N2770/38023 , C12N2770/38043 , C12N2799/02 , C12N2810/855
摘要： This invention is a process for the manufacture of a plant viral capsid to be used for the targeted delivery of therapeutics to diseased cells. The process uses a plant virus as the starting material. The choice of the plant virus overcomes a problem in the manufacture of a uniform starting material. The final product has an advantage over other plant virus-based delivery systems in that the plant virus selected has a natural structure that is resistant to breakdown during the delivery process. This system takes advantage of the reversible divalent cation switch that this capsid employs to assemble and disassemble.
摘要翻译： 本发明是一种用于制造用于向病变细胞靶向递送治疗剂的植物病毒衣壳的方法。 该过程使用植物病毒作为起始材料。 植物病毒的选择克服了制造均匀原料的问题。 最终产品优于其他基于植物病毒的递送系统，因为所选择的植物病毒具有在递送过程中耐破坏的天然结构。 该系统利用该衣壳用于组装和拆卸的可逆二价阳离子开关。
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10.发明授权公开(公告)号：US08273925B2
公开(公告)日：2012-09-25
申请号：US12524172
申请日：2007-12-08
申请人： Stefan Franzen , Thomas Koelker
发明人： Stefan Franzen , Thomas Koelker
CPC分类号： C08G65/2609 , C08G65/2615 , C08G65/2621 , C08G65/2696
摘要： A method for the production of alkylene oxide addition products comprising (i) charging a stirred reactor with a starting compound capable of adding on or inserting alkylene oxides, introducing at least one alkylene oxide plus a different diluent gas, wherein a portion of said alkylene oxide reacts in a liquid phase with said starting compound, and the remaining alkylene oxide together with said diluent gas forms a gas phase above the liquid phase, (ii) continuously drawing off said liquid phase from the bottom of the reactor via an outlet stub, and recycling to the top of the reactor via an external circulation system, which comprises at least one heat exchanger and at least one Venturi nozzle within said external circulation system, and (iii) metering said gas phase comprising alkylene oxide into said Venturi nozzle via a vacuum line.
摘要翻译： 一种用于生产环氧烷加成产物的方法，包括（i）向搅拌反应器中加入能够加入或插入烯化氧的起始化合物，引入至少一种环氧烷加上不同的稀释气体，其中一部分所述环氧烷烃 在液相中与所述起始化合物反应，剩余的环氧烷与所述稀释气体一起在液相上形成气相，（ii）经由出口残渣从反应器的底部连续地抽出液相，以及 通过外部循环系统再循环到反应器的顶部，外部循环系统包括至少一个热交换器和在所述外部循环系统内的至少一个文丘里喷嘴，以及（iii）通过真空将所述包含环氧烷的气相计量到所述文丘里喷嘴中 线。
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