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公开(公告)号：US10583429B2
公开(公告)日：2020-03-10
申请号：US14657701
申请日：2015-03-13
Inventor： Steven Cramer , James Woo , Hong Chen , Jiali Liao , Russell Frost
Abstract: The present disclosure is directed to mixed mode chromatography media comprising a ligand directly attached to a solid support. In some aspects, the ligand has a chemical formula of The mixed mode chromatography media is useful for binding and purifying proteins from a solution.
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Patent Agency Ranking
公开(公告)号：US20150258539A1
公开(公告)日：2015-09-17
申请号：US14657701
申请日：2015-03-13
Inventor： Steven Cramer , James Woo , Hong Chen , Jiali Liao , Russell Frost
Abstract: Mixed mode ligands, as well their use for purifying proteins, are provided.
Abstract translation: 提供了混合模式配体，以及它们用于纯化蛋白质的用途。
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公开(公告)号：US20200224144A1
公开(公告)日：2020-07-16
申请号：US16499780
申请日：2018-03-30
Inventor： J. Christopher Love , Kerry R. Love , Laura Crowell , Alan Stockdale , Richard Dean Braatz , Amos Enshen Lu , Steven Cramer , Steven Timmick , Nicholas Vecchiarello , Chaz Goodwine , Craig A. Mascarenhas
Abstract: Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments, these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.
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公开(公告)号：US20230053902A1
公开(公告)日：2023-02-23
申请号：US17690876
申请日：2022-03-09
Inventor： J. Christopher Love , Kerry R. Love , Laura Crowell , Alan Stockdale , Richard Dean Braatz , Amos Enshen Lu , Steven Cramer , Steven Timmick , Nicholas Vecchiarello , Chaz Goodwine , Craig A. Mascarenhas
Abstract: Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments; these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.
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公开(公告)号：US20250092089A1
公开(公告)日：2025-03-20
申请号：US18890289
申请日：2024-09-19
Applicant: North Carolina State University , Merck Sharp and Dohme LLC , EMD Millipore Corporation , Rensselaer Polytechnic Institute
Inventor： Stefano Menegatti , Ruben G. Carbonell , Jacob P. LeBarre , Cristiana Boi , Steven Cramer , Michael Phillips , David Roush
Abstract: The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
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6.发明申请公开(公告)号：US20200251186A1
公开(公告)日：2020-08-06
申请号：US16499776
申请日：2018-03-30
Inventor： J. Christopher Love , Kerry R. Love , Steven Cramer , Steven Timmick , Nicholas Vecchiarello , Chaz Goodwine , Laura Crowell , Alan Stockdale , Richard Dean Braatz , Amos Enshen Lu
Abstract: Systems and methods for generating and evaluating candidate sequences of partitioning steps to partition at least one biologically produced product from at least one impurity. In some embodiments, a plurality of candidate sequences of partitioning steps may be generated, wherein at least one candidate sequence of the plurality of candidate sequences comprises a plurality of partitioning steps in a specified order. The plurality of candidate sequences may be evaluated. For instance, a data set associated with the at least one partitioning step may be accessed, the data set comprising: first data indicative of a behavior of the at least one biologically produced product with respect to the at least one partitioning step; and second data indicative of a behavior of the at least one impurity with respect to the at least one partitioning step. The at least one candidate sequence may be scored based at least in part on the data set.
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