公开(公告)号：US11266720B2

公开(公告)日：2022-03-08

申请号：US16270302

申请日：2019-02-07

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Jennifer A. Dumont ,  Susan Low ,  Alan J. Bitonti ,  Glenn Pierce ,  Alvin Luk ,  Haiyan Jiang ,  Byron McKinney ,  Matt Ottmer ,  Jurg Sommer ,  Karen Nugent ,  Lian Li ,  Robert Peters

IPC: C07K14/755 ,  A61K38/37 ,  A61K47/64 ,  A61K47/68 ,  C07K16/46

Abstract: The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

公开(公告)号：US10881742B2

公开(公告)日：2021-01-05

申请号：US15991629

申请日：2018-05-29

Applicant: Bioverativ Therapeutics Inc.

Inventor： Jennifer A. Dumont ,  Susan Low ,  Alan J. Bitonti ,  Glenn Pierce ,  Alvin Luk ,  Haiyan Jiang ,  Byron McKinney ,  Matt Ottmer ,  Jurg Sommer ,  Karen Nugent ,  Lian Li ,  Robert T. Peters

IPC: A61K38/37 ,  A61K47/68 ,  A61K47/60 ,  C07K14/755 ,  G01N33/86

Abstract: The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

公开(公告)号：US11168125B2

公开(公告)日：2021-11-09

申请号：US16518642

申请日：2019-07-22

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K14/755 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  A61K47/68 ,  C07K14/565 ,  C12N9/96 ,  A61K47/60 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64 ,  A61K38/00

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US10023628B2

公开(公告)日：2018-07-17

申请号：US14412823

申请日：2013-07-05

Applicant: Bioverativ Therapeutics Inc.

Inventor： Susan Low ,  Jennifer A. Dumont ,  Alan J. Bitonti

IPC: C07K14/765 ,  A61K38/00 ,  A61K35/00 ,  C07K14/755

Abstract: The present invention provides cell lines for producing single chain FVIII polypeptides, e.g., chimeric single chain FVIII polypeptides, methods of producing single chain FVIII polypeptides, single chain FVIII polypeptides, and methods of treating Hemophilia A with a single chain Factor VIII polypeptide.

公开(公告)号：US09725496B1

公开(公告)日：2017-08-08

申请号：US15491742

申请日：2017-04-19

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K14/715 ,  C07K14/72 ,  C07K14/475 ,  C07K14/755 ,  C07K14/705 ,  C07K14/61 ,  C07K14/56 ,  C07K14/505 ,  C07K14/59 ,  C07K14/565 ,  A61K47/48 ,  C12N9/64 ,  C12N9/96 ,  A61K38/00

CPC classification number: C07K14/755 ,  A61K38/00 ,  A61K47/60 ,  A61K47/642 ,  A61K47/68 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6835 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/59 ,  C07K14/61 ,  C07K14/70503 ,  C07K14/745 ,  C07K16/00 ,  C07K2317/52 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/647 ,  C12N9/96 ,  C12Y304/21021 ,  C12Y304/21022

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US12186375B2

公开(公告)日：2025-01-07

申请号：US17112280

申请日：2020-12-04

Applicant: Bioverativ Therapeutics Inc.

Inventor： Jennifer A. Dumont ,  Susan Low ,  Alan J. Bitonti ,  Glenn Pierce ,  Alvin Luk ,  Haiyan Jiang ,  Byron McKinney ,  Matt Ottmer ,  Jurg Sommer ,  Karen Nugent ,  Lian Li ,  Robert T. Peters

IPC: A61K38/37 ,  A61K47/60 ,  A61K47/68 ,  C07K14/755 ,  G01N33/86

Abstract: The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

公开(公告)号：US20200071385A1

公开(公告)日：2020-03-05

申请号：US16518642

申请日：2019-07-22

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K14/755 ,  A61K47/68 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  C07K14/565 ,  C12N9/96 ,  A61K47/60 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US20190010212A1

公开(公告)日：2019-01-10

申请号：US16006594

申请日：2018-06-12

Applicant: Bioverativ Therapeutics Inc.

Inventor： Susan Low ,  Jennifer A. Dumont ,  Alan J. Bitonti

IPC: C07K14/755 ,  A61K35/00 ,  A61K38/00

Abstract: The present invention provides cell lines for producing single chain FVIII polypeptides, e.g., chimeric single chain FVIII polypeptides, methods of producing single chain FVIII polypeptides, single chain FVIII polypeptides, and methods of treating Hemophilia A with a single chain Factor VIII polypeptide.

公开(公告)号：US11084866B2

公开(公告)日：2021-08-10

申请号：US15465319

申请日：2017-03-21

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K19/00 ,  A61K39/00 ,  C07K14/755 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  A61K47/68 ,  C07K14/565 ,  C12N9/96 ,  A61K47/60 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64 ,  A61K38/00

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US10513551B2

公开(公告)日：2019-12-24

申请号：US15465319

申请日：2017-03-21

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K19/00 ,  A61K39/00 ,  C07K14/755 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  C12N9/96 ,  A61K47/60 ,  A61K47/68 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64 ,  A61K38/00

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.