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    Indazolyl derivatives useful as potassium channel modulating agents
    1.
    发明授权
    Indazolyl derivatives useful as potassium channel modulating agents 有权
    可用作钾通道调节剂的吲唑基衍生物

    公开(公告)号：US08222262B2

    公开(公告)日：2012-07-17

    申请号：US12444344

    申请日：2007-10-03

    申请人： Birgitte L. Eriksen ,  Ulrik Svane Sørensen ,  Charlotte Hougaard ,  Lene Teuber ,  Dan Peters ,  Palle Christophersen ,  Tina Holm Johansen

    发明人： Birgitte L. Eriksen ,  Ulrik Svane Sørensen ,  Charlotte Hougaard ,  Lene Teuber ,  Dan Peters ,  Palle Christophersen ,  Tina Holm Johansen

    IPC分类号： A61K31/517

    CPC分类号： C07D403/04 ,  C07D401/04

    摘要： Potassium channel modulating agents of Formula Ia or Ib and enantiomers and mixtures enantiomers and N-oxides thereof, and pharmaceutically acceptable salts thereof, and their use in the preparation of pharmaceutical compositions. Also, pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, e.g., respiratory diseases, epilepsy, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, schizophrenia, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labor, baldness, cancer, immune suppression, or pain.

    摘要翻译： 式Ia或Ib的钾通道调节剂及其对映异构体及其混合物对映异构体和N-氧化物及其药学上可接受的盐及其在制备药物组合物中的用途。 此外，可用于治疗或缓解与钾通道活动相关的疾病或病症的药物组合物，例如呼吸系统疾病，癫痫，惊厥，血管痉挛，冠状动脉痉挛，肾脏疾病，多囊肾病，膀胱痉挛，尿失禁 ，膀胱流出阻塞，肠易激综合征，胃肠功能障碍，分泌性腹泻，局部缺血，脑缺血，缺血性心脏病，心绞痛，冠心病，创伤性脑损伤，精神病，精神分裂症，焦虑症，抑郁症，痴呆，记忆和注意力缺陷， 老年痴呆症，痛经，发作性睡眠，雷诺病，间歇性跛行，Sjorgren综合征，偏头痛，心律失常，高血压，不存在癫痫发作，强直肌营养不良，口干燥症，II型糖尿病，高胰岛素血症，早产，秃发，癌症，免疫抑制或疼痛。

    INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS
    10.
    发明申请
    INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS 有权
    有用的盐酸衍生物作为钾通道调节剂

    公开(公告)号：US20090325989A1

    公开(公告)日：2009-12-31

    申请号：US12444344

    申请日：2007-10-03

    申请人： Birgitte L. Eriksen ,  Ulrik Svane Sorensen ,  Charlotte Hougaard ,  Lene Teuber ,  Dan Peters ,  Palle Christophersen ,  Tina Holm Johansen

    发明人： Birgitte L. Eriksen ,  Ulrik Svane Sorensen ,  Charlotte Hougaard ,  Lene Teuber ,  Dan Peters ,  Palle Christophersen ,  Tina Holm Johansen

    IPC分类号： A61K31/506 ,  C07D401/04 ,  A61P9/10

    CPC分类号： C07D403/04 ,  C07D401/04

    摘要： This invention relates to novel indazolyl derivatives useful as potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions.Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular respiratory diseases, epilepsy, convulsions, seizures, absence seizures, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, erectile dysfunction, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, autism, ataxia, traumatic brain injury, Parkinson's disease, bipolar disorder, psychosis, schizophrenia, anxiety, depression, mania, mood disorders, dementia, memory and attention deficits, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, arrhythmia, hypertension, myotonic muscle dystrophia, spasticity, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, irritable bowel syndrome, immune suppression, migraine and pain.

    摘要翻译： 本发明涉及可用作钾通道调节剂的新的吲唑基衍生物及其在制备药物组合物中的用途。 此外，本发明涉及可用于治疗或减轻与钾通道活性相关的疾病或病症的药物组合物，特别是呼吸系统疾病，癫痫，抽搐，癫痫发作，不发作，痉挛，血管痉挛，冠状动脉痉挛，肾脏疾病， 多囊肾病，膀胱痉挛，尿失禁，膀胱流出阻塞，勃起功能障碍，胃肠功能障碍，分泌性腹泻，局部缺血，脑局部缺血，缺血性心脏病，心绞痛，冠心病，自闭症，共济失调，创伤性脑损伤，帕金森病， 双相障碍，精神病，精神分裂症，焦虑症，抑郁症，躁狂症，情绪障碍，痴呆，记忆和注意力缺陷，阿尔茨海默病，肌萎缩性侧索硬化（ALS），痛经，发作性睡眠，雷诺病，间歇性跛行，Sjorgren综合征，心律失常，高血压， 肌筋膜肌营养不良，痉挛，x 老年糖尿病，II型糖尿病，高胰岛素血症，早产，秃发，癌症，肠易激综合征，免疫抑制，偏头痛和疼痛。