公开(公告)号：US20100029685A1

公开(公告)日：2010-02-04

申请号：US12447205

申请日：2007-10-24

申请人： Bjarne H. Dahl ,  Dan Peters ,  Gunnar M. Olsen ,  Daniel B. Timmermann ,  Susanne Jorgensen

发明人： Bjarne H. Dahl ,  Dan Peters ,  Gunnar M. Olsen ,  Daniel B. Timmermann ,  Susanne Jorgensen

IPC分类号： A61K31/4965 ,  C07D271/07 ,  C07D401/14 ,  C07D285/08 ,  C07D413/04 ,  C07D417/04 ,  A61K31/4439 ,  A61K31/4155 ,  A61P25/28 ,  A61P25/02

CPC分类号： C07D413/14 ,  C07D285/12 ,  C07D285/135 ,  C07D413/04 ,  C07D417/04

摘要： This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及恶二唑基和噻二唑基衍生物，其被发现是烟碱型乙酰胆碱受体的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20060235090A1

公开(公告)日：2006-10-19

申请号：US10541224

申请日：2003-12-09

申请人： Poul Nielsen ,  Susanne Jorgensen

发明人： Poul Nielsen ,  Susanne Jorgensen

IPC分类号： C07C27/26

CPC分类号： C07C29/145 ,  B01J23/72 ,  B01J23/80 ,  C07C29/141 ,  C07C29/1516 ,  C07C29/154 ,  C07C29/156 ,  Y02P20/142 ,  Y02P20/52 ,  C07C31/04 ,  C07C31/10 ,  C07C31/12

摘要： The invention provides a process for production of methanol from a feed stream rich in hydrogen carbon monoxide and carbon dioxide. The feed stream is converted to a converted process stream comprising methanol and small amounts of higher alcohols, aldehydes and ketones in the presence of a catalyst active in conversion of hydrogen and carbon monoxide into methanol. The converted process stream is cooled to a cooled process stream to 20-200° C. The cooled process stream is hydrogenated into a hydrogenated process stream rich in methanol and depleted in aldehydes and ketones in presence of a hydrogenation catalyst. The catalyst is active in conversion of aldehydes and ketones into alcohols in a process stream rich in methanol and further comprising hydrogen, carbon monoxide and carbon dioxide. The hydrogenated process stream is cooled to a cooled, condensed process stream, and subsequently the cooled, condensed process stream is separated into a gas phase and a liquid crude methanol phase.

摘要翻译： 本发明提供从富含氢一氧化碳和二氧化碳的进料流中生产甲醇的方法。 在催化剂存在下，将氢气和一氧化碳转化成甲醇，将原料流转化成包含甲醇和少量高级醇，醛和酮的转化过程物流。 将转化的工艺流冷却至冷却的工艺流至20-200℃。将冷却的工艺流体氢化成氢化催化剂存在下富含甲醇并在醛和酮中消耗的氢化工艺流。 催化剂在富含甲醇的工艺流中将醛和酮转化为醇是有活性的，并且还包含氢气，一氧化碳和二氧化碳。 将氢化工艺流冷却至冷却的冷凝工艺物流，随后将冷却的冷凝工艺物流分离成气相和液体粗甲醇相。