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公开(公告)号:US20100113414A1
公开(公告)日:2010-05-06
申请号:US12685213
申请日:2010-01-11
申请人: Bodo BETZEMEIER , Trixi BRANDL , Steffen BREITFELDER , Ralph BRUECKNER , Thomas GERSTBERGER , Michael GMACHL , Matthias GRAUERT , Frank HILBERG , Christoph HOENKE , Matthias HOFFMANN , Maria IMPAGNATIELLO , Dirk KESSLER , Christian KLEIN , Bernd KRIST , Udo MAIER , Darryl McCONNELL , Charlotte REITHER , Stefan SCHEUERER , Andreas SCHOOP , Norbert SCHWEIFER , Oliver SIMON , Martin STEEGMAIER , Steffen STEURER , Irene WAIZENEGGER , Ulrike WEYER-CZERNILOFSKY , Andreas ZOEPHEL
发明人: Bodo BETZEMEIER , Trixi BRANDL , Steffen BREITFELDER , Ralph BRUECKNER , Thomas GERSTBERGER , Michael GMACHL , Matthias GRAUERT , Frank HILBERG , Christoph HOENKE , Matthias HOFFMANN , Maria IMPAGNATIELLO , Dirk KESSLER , Christian KLEIN , Bernd KRIST , Udo MAIER , Darryl McCONNELL , Charlotte REITHER , Stefan SCHEUERER , Andreas SCHOOP , Norbert SCHWEIFER , Oliver SIMON , Martin STEEGMAIER , Steffen STEURER , Irene WAIZENEGGER , Ulrike WEYER-CZERNILOFSKY , Andreas ZOEPHEL
IPC分类号: A61K31/397 , C07D417/14 , A61K31/4439 , C07D513/02 , A61K31/429 , C07D213/02 , A61K31/4545 , C07D401/14 , A61K31/444 , C07D403/02 , A61K31/497 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D267/10 , A61K31/553 , C07D223/02 , A61K31/55 , C07D243/08 , A61K31/551 , A61P35/00
CPC分类号: C07D513/04 , C07D277/84
摘要: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗特征为过度或异常细胞增殖的疾病,以及其用于制备具有上述 属性。
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公开(公告)号:US20100152167A1
公开(公告)日:2010-06-17
申请号:US12711364
申请日:2010-02-24
申请人: Georg DAHMANN , Frank HIMMELSBACH , Bernd KRIST , Martin LENTER , Alexander PAUTSCH , Gisela SCHNAPP , Martin STEEGMAIER , Helmut WITTNEBEN , Anthony S. PROKOPOWICZ , Walter SPEVAK , Andreas SCHOOP , Steffen STEURER
发明人: Georg DAHMANN , Frank HIMMELSBACH , Bernd KRIST , Martin LENTER , Alexander PAUTSCH , Gisela SCHNAPP , Martin STEEGMAIER , Helmut WITTNEBEN , Anthony S. PROKOPOWICZ , Walter SPEVAK , Andreas SCHOOP , Steffen STEURER
IPC分类号: A61K31/505 , C07D239/50 , C07D413/12 , A61K31/5377 , A61K31/506 , C07D403/04 , A61K31/55 , C07D403/12 , A61K31/551 , A61P31/00 , A61P35/00 , A61P9/00 , A61P19/08
CPC分类号: C07D239/48 , C07D231/12 , C07D233/56 , C07D239/50 , C07D239/80 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10
摘要: The present invention relates to trisubstituted pyrimidines of formula (I) wherein0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterised by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
摘要翻译: 本发明涉及式(I)的三取代嘧啶,其中0Ra至Re如权利要求1所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,其用于制备具有上述药物组合物的用途 性质及其制备方法。
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公开(公告)号:US20130281429A1
公开(公告)日:2013-10-24
申请号:US13850711
申请日:2013-03-26
申请人: Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
发明人: Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
IPC分类号: C07D239/48 , C07D401/14 , C07D401/12 , C07D487/08 , A61K31/5377 , A61K45/06 , A61K31/506 , A61K31/505 , A61K31/551 , C07D403/12 , C07D409/14
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D487/08
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述药物组合物的用途 提到的属性。
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公开(公告)号:US20110251174A1
公开(公告)日:2011-10-13
申请号:US13159787
申请日:2011-06-14
申请人: Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
发明人: Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
IPC分类号: A61K31/506 , A61K31/505 , C07D403/12 , A61K31/551 , C07D413/14 , A61P35/00 , C07D401/14 , C07D401/12 , C07D413/12 , C07D487/08 , C07D409/14 , C07D239/48 , A61K31/5377
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D487/08
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述药物组合物的用途 提到的属性。
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公开(公告)号:US20110086842A1
公开(公告)日:2011-04-14
申请号:US12972976
申请日:2010-12-20
申请人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号: A61K31/553 , A61K31/506 , A61K31/5355 , A61P35/00 , A61P31/00 , A61P37/00
CPC分类号: C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中A,W,X,Y,Z,Ra,Rb,Rc,R 1和R 3如权利要求1中所定义,其适用于治疗以过量 或异常细胞增殖,以及其用于制备具有上述性质的药物组合物的用途。
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公开(公告)号:US20090149438A1
公开(公告)日:2009-06-11
申请号:US12366078
申请日:2009-02-05
申请人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号: A61K31/5377 , C07D413/14 , C07D403/12 , A61K31/506 , A61K31/551 , C07D409/14 , A61K31/553
CPC分类号: C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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公开(公告)号:US20090163465A1
公开(公告)日:2009-06-25
申请号:US12366075
申请日:2009-02-05
申请人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号: A61K31/506 , A61K31/55 , A61K31/553 , A61K31/551 , A61P35/00
CPC分类号: C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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公开(公告)号:US20110257207A1
公开(公告)日:2011-10-20
申请号:US13105957
申请日:2011-05-12
申请人: Alexander BACKES , Joachim VOGT , Peter AMON , Igor IVANOV , Stefan HANNUS , Matthias BORGMANN , Kerrin HANSEN , Rebecca CASAUBON , Chase SMITH , Krishna MURTHI , Arthur KLUGE , Andreas SCHOOP , Lars NEUMANN , Jan EICKHOFF
发明人: Alexander BACKES , Joachim VOGT , Peter AMON , Igor IVANOV , Stefan HANNUS , Matthias BORGMANN , Kerrin HANSEN , Rebecca CASAUBON , Chase SMITH , Krishna MURTHI , Arthur KLUGE , Andreas SCHOOP , Lars NEUMANN , Jan EICKHOFF
IPC分类号: A61K31/519 , A61P35/00 , C07D471/04
CPC分类号: C07D471/04
摘要: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
摘要翻译: 本发明提供吡啶并[2,3-d]嘧啶-7-酮的衍生物。 这些化合物是抑制剂或激酶如Raf,包括显示抗增殖活性的化合物,包括抗肿瘤细胞,并且可用于治疗包括癌症在内的疾病。
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