-
公开(公告)号:US07691888B2
公开(公告)日:2010-04-06
申请号:US11243796
申请日:2005-10-05
申请人: Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人: Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号: A61K31/429 , A61K31/4162 , C07D513/02 , C07D417/14
CPC分类号: C07D513/04 , C07D277/84
摘要: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗特征为过度或异常细胞增殖的疾病,以及其用于制备具有上述 属性。
-
公开(公告)号:US08207349B2
公开(公告)日:2012-06-26
申请号:US12685213
申请日:2010-01-11
申请人: Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人: Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号: C07D277/60
CPC分类号: C07D513/04 , C07D277/84
摘要: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗特征为过度或异常细胞增殖的疾病,以及其用于制备具有上述 属性。
-
公开(公告)号:US20060100254A1
公开(公告)日:2006-05-11
申请号:US11243796
申请日:2005-10-05
申请人: Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人: Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号: A61K31/429 , C07D513/02
CPC分类号: C07D513/04 , C07D277/84
摘要: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in Claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3定义如权利要求1,其适用于治疗以下特征的疾病: 过度或异常细胞增殖,以及它们用于制备具有上述性质的药物。
-
公开(公告)号:US08304556B2
公开(公告)日:2012-11-06
申请号:US13347797
申请日:2012-01-11
申请人: Darryl McConnell , Maria Impagnatiello , Dirk Kessler , Oliver Kraemer , Siegfried Schneider , Lars Van Der Veen , Ulrike Weyer-Czernilofsky , Tobias Wunberg
发明人: Darryl McConnell , Maria Impagnatiello , Dirk Kessler , Oliver Kraemer , Siegfried Schneider , Lars Van Der Veen , Ulrike Weyer-Czernilofsky , Tobias Wunberg
IPC分类号: A61K31/429 , C07D513/04
CPC分类号: C07D513/04
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述特征的药物的用途, 上述属性。
-
公开(公告)号:US20110118208A1
公开(公告)日:2011-05-19
申请号:US12921588
申请日:2009-03-13
申请人: Darryl Mcconnell , Maria Impagnatiello , Dirk Kessler , Oliver Kraemer , Siegfried Schneider , Lars Van Der Veen , Ulrike Weyer-Czernilofsky , Tobias Wunberg
发明人: Darryl Mcconnell , Maria Impagnatiello , Dirk Kessler , Oliver Kraemer , Siegfried Schneider , Lars Van Der Veen , Ulrike Weyer-Czernilofsky , Tobias Wunberg
IPC分类号: A61K31/69 , C07D513/04 , C07F5/02 , A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/444 , A61K31/496 , A61P35/00 , A61P31/00 , A61P29/00 , A61P37/06
CPC分类号: C07D513/04
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述特征的药物的用途, 上述属性。
-
公开(公告)号:US20110281838A1
公开(公告)日:2011-11-17
申请号:US13055949
申请日:2009-07-28
申请人: Tobias Wunberg , Ralph Brueckner , Dirk Kessler , Oliver Kraemer , Darryl McConnell , Siegfried Schneider , Lars van der Veen
发明人: Tobias Wunberg , Ralph Brueckner , Dirk Kessler , Oliver Kraemer , Darryl McConnell , Siegfried Schneider , Lars van der Veen
IPC分类号: A61K31/506 , C07D401/06 , C07D471/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/505 , A61K31/5377 , A61K31/541 , A61P35/00 , A61P31/00 , A61P29/00 , A61P37/00 , C07D239/42
CPC分类号: C07D401/06 , C07D239/48 , C07D401/04 , C07D403/06 , C07D403/14 , C07D409/06 , C07D413/14
摘要: The present invention encompasses compounds of general Formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 4如权利要求1所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述药物的药物的用途, 上述属性。
-
公开(公告)号:US08916548B2
公开(公告)日:2014-12-23
申请号:US13055949
申请日:2009-07-28
申请人: Tobias Wunberg , Ralph Brueckner , Dirk Kessler , Oliver Kraemer , Darryl McConnell , Siegfried Schneider , Lars van der Veen
发明人: Tobias Wunberg , Ralph Brueckner , Dirk Kessler , Oliver Kraemer , Darryl McConnell , Siegfried Schneider , Lars van der Veen
IPC分类号: C07D239/48 , C07D401/04 , C07D403/06
CPC分类号: C07D401/06 , C07D239/48 , C07D401/04 , C07D403/06 , C07D403/14 , C07D409/06 , C07D413/14
摘要: The present invention encompasses compounds of general Formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 4如权利要求1所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述药物的药物的用途, 上述属性。
-
公开(公告)号:US09422290B2
公开(公告)日:2016-08-23
申请号:US14076507
申请日:2013-11-11
申请人: Harald Engelhardt , Davide Gianni , Dirk Kessler , Ulrich Reiser , Christian Smethurst , Andreas Steffen
发明人: Harald Engelhardt , Davide Gianni , Dirk Kessler , Ulrich Reiser , Christian Smethurst , Andreas Steffen
IPC分类号: C07D487/04 , A61K31/5025 , A61K45/06
CPC分类号: C07D487/04 , A61K31/5025 , A61K45/06 , A61K2300/00
摘要: Disclosed are compounds of general formula (I) wherein the groups R1 to R3 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译: 公开了通式(I)的化合物,其中基团R 1至R 3具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物,其含有这些化合物及其作为药物的用途。
-
公开(公告)号:US09321771B2
公开(公告)日:2016-04-26
申请号:US14087179
申请日:2013-11-22
IPC分类号: A61K31/495 , C07D239/26 , C07D471/10 , C07D239/48 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/08
CPC分类号: A61K31/553 , A61K31/495 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , C07D239/26 , C07D239/48 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/08
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗以细胞增殖过度或异常为特征的疾病,以及其用于制备具有上述特征的药物的用途, 上述属性。
-
公开(公告)号:US08935752B1
公开(公告)日:2015-01-13
申请号:US12409449
申请日:2009-03-23
申请人: Shun Chen , Richard Bruce Dandliker , Phillip DiCorpo , Bruce Christopher Wootton , Dirk Kessler , Timothy Micheal Wyatt
发明人: Shun Chen , Richard Bruce Dandliker , Phillip DiCorpo , Bruce Christopher Wootton , Dirk Kessler , Timothy Micheal Wyatt
CPC分类号: H04W12/08 , G06Q10/10 , H04L63/1408
摘要: A method and apparatus for identity consolidation for a plurality of electronic identities is described. In one embodiment, the method includes receiving user identification data extracted from an electronic communication, the user identification data corresponding to an unknown identity of a sender of the electronic communication. The method further includes determining a known identity for the sender using the user identification data extracted from the electronic communication and associating the known identity with the unknown identity of the sender of the electronic communication. In one embodiment, an association between the known identity and the unknown identity is maintained to determine whether parties of subsequent information transfers are authorized to participate in the information transfers.
摘要翻译: 描述了用于多个电子身份的身份合并的方法和装置。 在一个实施例中,该方法包括接收从电子通信提取的用户标识数据,与电子通信的发送者的未知身份相对应的用户标识数据。 该方法还包括使用从电子通信提取的用户标识数据确定发送者的已知身份,并将已知身份与电子通信的发送者的未知身份相关联。 在一个实施例中,保持已知身份和未知身份之间的关联,以确定后续信息传送的各方是否被授权参与信息传送。
-
-
-
-
-
-
-
-
-