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    Biosensing meter with ambient temperature estimation method and system
    1.
    发明授权
    Biosensing meter with ambient temperature estimation method and system 失效
    具有环境温度估计方法和系统的生物传感仪

    公开(公告)号：US5405511A

    公开(公告)日：1995-04-11

    申请号：US073179

    申请日：1993-06-08

    申请人： Bradley E. White ,  Michael L. Brown ,  Paul G. Ritchie ,  Vladimir Svetnik ,  Robert A. Parks ,  Stefan Weinert

    发明人： Bradley E. White ,  Michael L. Brown ,  Paul G. Ritchie ,  Vladimir Svetnik ,  Robert A. Parks ,  Stefan Weinert

    IPC分类号： G01N27/26 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

    CPC分类号： G01N27/3274 ,  G01K7/42

    摘要： A biosensing meter is provided that determines a value of an analyte in a biological sample. The meter employs an algorithm for determining the analyte value, which value is dependent upon ambient temperature about the biological sample when it is present in a reaction zone. The biosensing meter includes a processor and a temperature sensor. The temperature sensor is positioned within the meter's structure and thereby exhibits a delayed response to changes in the ambient temperature. The meter performs a temperature estimation method to overcome the delayed temperature response. The method commences by the meter repetitively and periodically acquiring temperature readings from the temperature sensor when the biosensing meter is both in an on state and in an off state. When the meter is in the on state, the algorithm estimates the ambient temperature by employing at least two most recent temperature readings and extrapolating therefrom to achieve an ambient temperature estimate. Temperature readings are acquired by the meter at first intervals when the meter is in the off state and at second, shorter intervals when the meter is in the on state, the temperature extrapolations only occurring when the meter is in the on state.

    摘要翻译： 提供了生物传感计，其确定生物样品中分析物的值。 仪表采用一种用于确定分析物值的算法，该值取决于生物样品当存在于反应区域时的环境温度。 生物传感计包括处理器和温度传感器。 温度传感器位于仪表结构内，从而对环境温度的变化表现出延迟的响应。 仪表执行温度估计方法以克服延迟温度响应。 当生物传感仪处于打开状态并处于关闭状态时，该仪器重复开始并周期性地从温度传感器获取温度读数。 当仪表处于打开状态时，该算法通过采用至少两个最近的温度读数来估计环境温度，并从中推断出来以实现环境温度估计。 当仪表处于关闭状态时，仪表以第一时间间隔获取温度读数，当仪表处于打开状态时以秒为单位，温度外推仅在仪表处于打开状态时发生。

    Biosensing meter with fail/safe procedures to prevent erroneous indications
    2.
    发明授权
    Biosensing meter with fail/safe procedures to prevent erroneous indications 失效
    生物传感仪具有故障/安全程序，以防止错误的指示

    公开(公告)号：US5352351A

    公开(公告)日：1994-10-04

    申请号：US73180

    申请日：1993-06-08

    申请人： Bradley E. White ,  Robert A. Parks ,  Paul G. Ritchie ,  Vladimir Svetnik

    发明人： Bradley E. White ,  Robert A. Parks ,  Paul G. Ritchie ,  Vladimir Svetnik

    IPC分类号： G01N27/26 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

    CPC分类号： G01N27/3273

    摘要： A biosensing meter receives a sample strip that includes electrically isolated sense and excitation electrodes bridged by a reaction zone. When a drop of biological sample fluid is placed in the reaction zone, a plurality of fail/safe tests are performed. A drop size test is performed by a circuit that detects the size of the drop placed in the reaction zone. The circuit both detects that a drop has been placed in the reaction zone and further measures a test current level, after a delay, to determine that the drop size is sufficient to enable hydration of reactants in the reaction zone. Subsequently, during the reaction, a "delta" current change is measured at succeeding sample time. This test measures the difference between succeeding current samples during a measurement time. If each succeeding sample is not less than preceding sample by a delta value, a determination is made that the current is not monotonically decreasing and the test is aborted. At the termination of the measurement time, a current sum test is performed wherein a processor calculates a linear sum of all sample test currents and calculates a ratio between that sum and the last current sample. If that ratio matches a pre-calculated constant for the Cottrell relationship, then it is known that the measurement values exhibit the Cottrell relationship.

    摘要翻译： 生物传感仪接收包含由反应区桥接的电隔离的感应和激发电极的样品条。 当将一滴生物样品流体置于反应区域中时，进行多次故障/安全试验。 通过检测放置在反应区中的液滴尺寸的电路进行液滴尺寸测试。 电路两者都检测到液滴已经放置在反应区域中，并且在延迟之后进一步测量测试电流水平，以确定液滴尺寸足以使反应物质在反应区域中水合。 随后，在反应期间，在随后的采样时间测量“delta”电流变化。 该测试测量测量时间中后续电流样本之间的差异。 如果每个后续样本不小于先前样本的Δ值，则确定电流不是单调递减，并且测试中止。 在测量时间结束时，执行电流和测试，其中处理器计算所有采样测试电流的线性和，并且计算该和与最后一个当前采样之间的比率。 如果该比率匹配Cottrell关系的预先计算的常数，则已知测量值表现出Cottrell关系。

    Biosensing meter with pluggable memory key
    3.
    发明授权
    Biosensing meter with pluggable memory key 失效
    具有可插拔内存密钥的Biosensing仪表

    公开(公告)号：US5366609A

    公开(公告)日：1994-11-22

    申请号：US73316

    申请日：1993-06-08

    申请人： Bradley E. White ,  Robert A. Parks ,  Paul G. Ritchie ,  Terry A. Beaty

    发明人： Bradley E. White ,  Robert A. Parks ,  Paul G. Ritchie ,  Terry A. Beaty

    IPC分类号： G01N27/26 ,  A61B5/00 ,  G01N27/416 ,  G01N27/49 ,  G01N33/487 ,  G01N35/00

    CPC分类号： G01N33/48792 ,  A61B2560/0475 ,  A61B5/1486 ,  G01N35/00732 ,  Y10S435/817

    摘要： A biosensing meter is enabled to receive a sample strip that includes a sample well with an analyte reactant therein and electrodes in contact therewith. The biosensing meter includes an excitation supply for supplying potentials to a sample strip electrode. A sense amplifier is also provided for connection to another electrode of an inserted sample strip and produces an output signal indicative of sensed currents when an analyte containing fluid is present in the strip's sample well. A pluggable memory key is insertable into the meter and includes a plurality of stored parameter values and procedure routines that control operations of the meter. A microprocessor is responsive to a procedure routine and parameter values accessed from the pluggable memory key to cause the excitation supply to apply a plurality of potentials for preset durations, both the values of the potentials and the time duration of their application determined from parameter values derived from the memory key. The microprocessor controls the sense amplifier to provide a plurality of signal outputs over a predetermined duration, the sense amplifier being operated under control of specific parameter values derived from the pluggable memory key. Replacement of a pluggable memory key with a memory key containing alternative procedures and parameters enables the biosensing meter to carry out substantially modified test procedures without a requirement for modification of the structure of the meter.

    摘要翻译： 生物传感仪能够接收包含样品孔的样品条，其中分析物反应物和与其接触的电极。 生物传感计包括用于向样品条电极供电的激励源。 还提供读出放大器用于连接到插入的样品条的另一电极，并且当带状样品阱中存在含有分析物的流体时，产生指示感测电流的输出信号。 可插拔存储器密钥可插入到仪表中，并且包括控制仪表操作的多个存储的参数值和过程程序。 微处理器响应于从可插拔存储器键访问的程序程序和参数值，以使激励电源施加多个电位以用于预设的持续时间，这两个值的电位值和其应用的持续时间是根据派生的参数值确定的 从内存密钥。 微处理器控制读出放大器在预定的持续时间内提供多个信号输出，读出放大器在来自可插拔存储器键的特定参数值的控制下操作。 使用包含备用程序和参数的存储钥匙替换可插拔存储钥匙使得生物传​​感计能够执行基本上改进的测试程序，而不需要修改仪表的结构。

    Biosensing meter which detects proper electrode engagement and distinguishes sample and check strips
    4.
    发明授权
    Biosensing meter which detects proper electrode engagement and distinguishes sample and check strips 失效
    检测适当的电极接合和区分样品和检查条的生物传感计

    公开(公告)号：US5438271A

    公开(公告)日：1995-08-01

    申请号：US343363

    申请日：1994-11-22

    申请人： Bradley E. White ,  Robert A. Parks ,  Paul G. Ritchie

    发明人： Bradley E. White ,  Robert A. Parks ,  Paul G. Ritchie

    IPC分类号： G01N27/26 ,  G01N27/28 ,  G01N27/416 ,  G01N33/487 ,  G01R27/02

    CPC分类号： G01N27/3273

    摘要： A biosensing meter receives a biomedical sample strip or a check strip, a sample strip including electrically isolated excitation and sense electrodes. The biosensing meter includes first and second contacts that are positioned to be electrically connected by a sense electrode when a sample strip is inserted into the biosensing meter. An operational amplifier circuit has one input connected to the first contact and a second input connected to a reference potential, the one input manifesting the reference potential as a result of a feedback within the operational amplifier. A processor is coupled to the second contact and determines the presence of the reference potential at the second contact when an inserted sense electrode connects the first and second contacts. The processor also distinguishes between a sample strip and a check strip and, when a sample strip is inserted, that the sample strip exhibits a proper impedance between its sense and excitation electrodes--to enable operation of the biosensing meter upon dosing of the sample strip.

    摘要翻译： 生物传感仪器接收生物医学样品条或检查条，包括电隔离的激发和感测电极的样品条。 生物传感计包括第一和第二触点，当将样品条插入生物传感计时，第一和第二触点定位成由感测电极电连接。 运算放大器电路具有连接到第一触点的一个输入端和连接到参考电位的第二输入，该一个输入作为运算放大器内部反馈的结果表现出参考电位。 当插入的感测电极连接第一和第二触点时，处理器耦合到第二触点并且确定在第二触点处存在参考电位。 处理器还区分样品条和检查条，并且当​​插入样品条时，样品条在其感测和激发电极之间呈现适当的阻抗，以使得能够在给样品条带上操作生物传感计。

    Biosensor electrode excitation circuit
    10.
    发明授权
    Biosensor electrode excitation circuit 失效
    生物传感器电极激励电路

    公开(公告)号：US4999582A

    公开(公告)日：1991-03-12

    申请号：US451108

    申请日：1989-12-15

    申请人： Robert A. Parks ,  Bradley E. White

    发明人： Robert A. Parks ,  Bradley E. White

    IPC分类号： G01N27/416 ,  G01N27/327 ,  G01N33/487 ,  G01R27/02

    CPC分类号： G01N27/3273

    摘要： A circuit is described for applying a potential to an electrode of a biosensing test cell, which electrode, when properly inserted in a female connector, is contacted by a pair spaced apart contacts. The circuit includes a source of excitation potential and an operational amplifier having one input connected to the source of excitation potential. A switching circuit is coupled between the operational amplifier and a first one of the spaced apart contacts, with the switch means exhibiting an impedance. A feedback circuit is connected between the second of the spaced-apart contacts and another input to the operational amplifier, to feed back a potential appearing at the second contact. The feedback is for the purpose of maintaining the output of the operational amplifier at a level which compensates for impedance losses in the swtiching circuit. The feedback circuit enables the output of the operational amplifier to be varied so that the potential applied to the electrode is equal to the source of excitation potential. A further circuit is connected to the feedback circuit for sensing when an open or high impedance state exists between the spaced-apart contacts.

    摘要翻译： 描述了将电位施加到生物传感测试电池的电极的电路，当适当地插入阴连接器中时，该电极被一对间隔开的触点接触。 该电路包括一个激励电位源和一个运算放大器，其中一个输入端连接到激励电位源。 开关电路耦合在运算放大器和间隔开的触点中的第一个之间，开关装置呈现阻抗。 反馈电路连接在第二间隔开的触点和另一个输入到运算放大器之间，以反馈在第二个触点处出现的电位。 反馈是为了将运算放大器的输出保持在补偿开关电路中的阻抗损耗的水平。 反馈电路使运算放大器的输出变化，使得施加到电极的电位等于激励电位源。 另一个电路连接到反馈电路，用于在间隔开的触点之间存在开路或高阻抗状态时进行感测。