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    Antisense oligonucleotide inhibition of ras
    4.
    发明授权
    Antisense oligonucleotide inhibition of ras 失效
    反义寡核苷酸抑制ras

    公开(公告)号：US06784290B1

    公开(公告)日：2004-08-31

    申请号：US09575554

    申请日：2000-05-22

    申请人： Brett P. Monia ,  Lex M. Cowsert ,  Muthiah Manoharan

    发明人： Brett P. Monia ,  Lex M. Cowsert ,  Muthiah Manoharan

    IPC分类号： C07H2102

    CPC分类号： C12N15/1135 ,  A61K38/00 ,  C07K14/82 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/333 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12Q2525/125 ,  C12N2310/3525

    摘要： Compositions and methods are provided for the modulation of ras expression. Oligonucleotides are provided which are targeted to nucleic acids encoding human ras. Oligonucleotides specifically hybridizable with mRNA encoding human H-ras, Ki-ras and N-ras are provided. Such oligonucleotides can be used for therapeutics and diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of activated ras. Methods for diagnosis, detection and treatment of conditions, or particular cancers, associated with ras are also disclosed.

    摘要翻译： 提供了ras表达调控的组成和方法。 提供了靶向编码人ras的核酸的寡核苷酸。 提供与编码人H-ras，Ki-ras和N-ras的mRNA特异性杂交的寡核苷酸。 这样的寡核苷酸可用于治疗和诊断以及用于研究目的。 还公开了使用所提供的寡核苷酸调节细胞和组织中的ras基因表达以及用于特异性调节活化的ras表达的方法。 还公开了与ras有关的病症或特定癌症的诊断，检测和治疗方法。

    Antisense modulation of PKA catalytic subunit C-alpha expression
    6.
    发明授权
    Antisense modulation of PKA catalytic subunit C-alpha expression 失效
    PKA催化亚基C-α表达的反义调制

    公开(公告)号：US06248586B1

    公开(公告)日：2001-06-19

    申请号：US09467082

    申请日：1999-12-17

    申请人： Brett P. Monia ,  Lex M. Cowsert

    发明人： Brett P. Monia ,  Lex M. Cowsert

    IPC分类号： C12N1585

    CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of PKA catalytic subunit C-alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PKA catalytic subunit C-alpha. Methods of using these compounds for modulation of PKA catalytic subunit C-alpha expression and for treatment of diseases associated with expression of PKA catalytic subunit C-alpha are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节PKA催化亚基C-α的表达。 组合物包含靶向编码PKA催化亚基C-α的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PKA催化亚基C-α表达和治疗与PKA催化亚基C-α表达相关的疾病的方法。

    Antisense oligonucleotide inhibition of ras
    9.
    发明授权
    Antisense oligonucleotide inhibition of ras 有权
    反义寡核苷酸抑制ras

    公开(公告)号：US6117848A

    公开(公告)日：2000-09-12

    申请号：US128494

    申请日：1998-08-03

    申请人： Brett P. Monia ,  Lex M. Cowsert ,  Muthiah Manoharan

    发明人： Brett P. Monia ,  Lex M. Cowsert ,  Muthiah Manoharan

    IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C07H21/04 ,  C07K14/82 ,  C12Q1/68 ,  C07H21/02

    CPC分类号： C07K14/82 ,  A61K38/00 ,  C12N2310/322 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12Q2525/125

    摘要： Compositions and methods are provided for the modulation of ras expression. Oligonucleotides are provided which are targeted to nucleic acids encoding human ras. Oligonucleotides specifically hybridizable with mRNA encoding human H-ras, Ki-ras and N-ras are provided. Such oligonucleotides can be used for therapeutics and diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of activated ras. Methods for diagnosis, detection and treatment of conditions associated with ras are also disclosed.

    摘要翻译： 提供了ras表达调控的组成和方法。 提供了靶向编码人ras的核酸的寡核苷酸。 提供与编码人H-ras，Ki-ras和N-ras的mRNA特异性杂交的寡核苷酸。 这样的寡核苷酸可用于治疗和诊断以及用于研究目的。 还公开了使用所提供的寡核苷酸调节细胞和组织中的ras基因表达以及用于特异性调节活化的ras表达的方法。 还公开了与ras相关的病症的诊断，检测和治疗方法。