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公开(公告)号:US20100323994A1
公开(公告)日:2010-12-23
申请号:US12866365
申请日:2009-02-06
申请人: Brian E. Fink , Soong-Hoon Kim , Yufen Zhao , Ping Chen , Wayne Vaccaro , Litai Zhang , Ashvinikumar V. Gaval , Dharmpal S. Dodd , Libing Chen
发明人: Brian E. Fink , Soong-Hoon Kim , Yufen Zhao , Ping Chen , Wayne Vaccaro , Litai Zhang , Ashvinikumar V. Gaval , Dharmpal S. Dodd , Libing Chen
IPC分类号: A61K31/5025 , C07D487/04 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/397 , A61P35/00 , A61P17/06 , A61P19/02
CPC分类号: C07D487/04
摘要: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译: 本发明提供式I化合物及其药学上可接受的盐。 式I咪唑并哒嗪抑制蛋白激酶活性,从而使其成为抗癌剂。
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公开(公告)号:US08389527B2
公开(公告)日:2013-03-05
申请号:US12866365
申请日:2009-02-06
申请人: Brian E. Fink , Soong-Hoon Kim , Yufen Zhao , Ping Chen , Wayne Vaccaro , Litai Zhang , Ashvinikumar V Gavai , Dharmpal S Dodd , Libing Chen
发明人: Brian E. Fink , Soong-Hoon Kim , Yufen Zhao , Ping Chen , Wayne Vaccaro , Litai Zhang , Ashvinikumar V Gavai , Dharmpal S Dodd , Libing Chen
IPC分类号: A01N43/58 , A01N43/60 , C61K31/50 , C07D487/00
CPC分类号: C07D487/04
摘要: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译: 本发明提供式I化合物及其药学上可接受的盐。 式I咪唑并哒嗪抑制蛋白激酶活性,从而使其成为抗癌剂。
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公开(公告)号:US08252795B2
公开(公告)日:2012-08-28
申请号:US12575589
申请日:2009-10-08
申请人: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
发明人: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC分类号: A01N43/58 , A61K31/50 , C07D487/00
CPC分类号: C07D487/04 , C07D498/04
摘要: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译: 本发明提供式(I)化合物及其药学上可接受的盐。 式(I)咪唑并哒嗪抑制蛋白激酶活性,从而使其成为抗癌剂。
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公开(公告)号:US20120283241A1
公开(公告)日:2012-11-08
申请号:US13552795
申请日:2012-07-19
申请人: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
发明人: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC分类号: A61K31/5025 , A61P35/00 , A61P17/06 , A61K31/538 , A61P35/02 , A61K31/5377 , C07D498/04 , C07D487/04 , A61P29/00
CPC分类号: C07D487/04 , C07D498/04
摘要: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译: 本发明提供式(I)化合物及其药学上可接受的盐。 式(I)咪唑并哒嗪抑制蛋白激酶活性,从而使其成为抗癌剂。
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公开(公告)号:US20100113458A1
公开(公告)日:2010-05-06
申请号:US12575589
申请日:2009-10-08
申请人: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
发明人: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC分类号: A61K31/5025 , C07D487/00
CPC分类号: C07D487/04 , C07D498/04
摘要: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译: 本发明提供式(I)化合物及其药学上可接受的盐。 式(I)咪唑并哒嗪抑制蛋白激酶活性,从而使其成为抗癌剂。
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6.1,6-naphthyridine derivatives and their use to treat diabetes and related disorders 失效
标题翻译: 1,6-萘啶衍生物及其用于治疗糖尿病和相关疾病的用途公开(公告)号:US06964971B2
公开(公告)日:2005-11-15
申请号:US10684299
申请日:2003-10-10
申请人: Yamin Wang , William H. Bullock , Libing Chen
发明人: Yamin Wang , William H. Bullock , Libing Chen
IPC分类号: A61K31/133 , A61K31/155 , A61K31/195 , A61K31/198 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/64 , A61K31/7034 , A61K38/22 , A61K38/28 , A61K45/00 , A61K45/06 , A61P3/04 , A61P3/10 , A61P5/12 , A61P5/42 , A61P9/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07D471/02 , C07D471/04
CPC分类号: A61K45/06 , A61K31/44 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , A61K2300/00
摘要: The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
摘要翻译: 本发明一般涉及下式的萘啶衍生物,其中U,X,Y和Z中的一个为氮,其余为C-R,其中R为氢或取代基。 更具体地,本发明涉及1,6-萘啶衍生物和含有这些衍生物的药物组合物。 本发明的方法包括施用本发明的萘啶衍生物用于治疗糖尿病和相关疾病。
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公开(公告)号:US07714004B2
公开(公告)日:2010-05-11
申请号:US10537630
申请日:2003-12-19
申请人: Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens
发明人: Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens
IPC分类号: A61K31/426 , C07D277/20
CPC分类号: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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8.Heteroarylaminopyrazole derivatives useful for the treatment of diabetes 失效
标题翻译: 可用于治疗糖尿病的杂芳基氨基吡唑衍生物公开(公告)号:US07517878B2
公开(公告)日:2009-04-14
申请号:US11064700
申请日:2005-02-24
申请人: Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
发明人: Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
IPC分类号: C07D403/12 , A61K31/4155
CPC分类号: C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14
摘要: The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译: 本发明涉及杂芳基氨基吡唑化合物,药物组合物和治疗糖尿病和相关疾病的方法。
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公开(公告)号:US07265144B2
公开(公告)日:2007-09-04
申请号:US10719485
申请日:2003-11-21
申请人: Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip L. Wickens
发明人: Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip L. Wickens
IPC分类号: A61K31/4152 , C07D231/44
CPC分类号: C07D231/38 , C07D401/04 , C07D403/12 , C07D413/12 , C07D471/04
摘要: The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译: 本发明涉及苯胺基吡唑化合物,药物组合物和治疗糖尿病及相关疾病的方法。
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公开(公告)号:US20060084680A1
公开(公告)日:2006-04-20
申请号:US10537630
申请日:2003-12-19
申请人: Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens
发明人: Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens
IPC分类号: A61K31/445 , A61K31/195 , A61K31/192
CPC分类号: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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