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公开(公告)号:US07244727B2
公开(公告)日:2007-07-17
申请号:US10720844
申请日:2003-11-21
申请人: Brian M. Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon M. Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin L. McMinn , Nobuya Ogawa , Steven M. Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
发明人: Brian M. Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon M. Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin L. McMinn , Nobuya Ogawa , Steven M. Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
IPC分类号: C07D498/04 , A61K31/542 , A61P3/04 , A61P3/08 , C07D491/04 , C07D495/04 , A61K31/538 , A61K31/519
CPC分类号: C07D491/04
摘要: Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.
摘要翻译: 本文提供了可用于治疗或预防代谢和细胞增殖性疾病或病症的化合物,药物组合物和方法。 特别地,本发明提供调节参与脂质代谢和细胞增殖的蛋白质的活性的化合物。
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公开(公告)号:US20070244096A1
公开(公告)日:2007-10-18
申请号:US11743376
申请日:2007-05-02
申请人: Brian Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin McMinn , Nobuya Ogawa , Steven Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
发明人: Brian Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin McMinn , Nobuya Ogawa , Steven Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
IPC分类号: A61K31/55 , A61K31/542 , A61K31/5383 , C07D497/02 , C07D498/02 , C07D491/02
CPC分类号: C07D491/04
摘要: Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.
摘要翻译: 本文提供了可用于治疗或预防代谢和细胞增殖性疾病或病症的化合物,药物组合物和方法。 特别地,本发明提供调节参与脂质代谢和细胞增殖的蛋白质的活性的化合物。
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公开(公告)号:US20070027093A1
公开(公告)日:2007-02-01
申请号:US11495095
申请日:2006-07-28
申请人: Nobuya Ogawa , Chihiro Okuma , Noboru Furukawa
发明人: Nobuya Ogawa , Chihiro Okuma , Noboru Furukawa
IPC分类号: A61K31/70 , A61K31/365 , A61K31/542 , A61K31/5383 , A61K31/519 , A61K31/426 , A61K31/22 , A61K31/175
CPC分类号: A61K31/5383 , A61K31/175 , A61K31/22 , A61K31/235 , A61K31/365 , A61K31/40 , A61K31/426 , A61K31/436 , A61K31/50 , A61K31/519 , A61K31/542 , A61K31/70 , A61K45/06 , A61K2300/00
摘要: The present invention relates to an anorectic containing a compound having a DGAT inhibitory activity (DGAT1 inhibitory activity) or a prodrug thereof or a pharmaceutically acceptable salt thereof as an active ingredient. The present invention provides an anti-obesity drug which is an anorectic that does not directly act on the central nervous system and is satisfactory in terms of activity, and a therapeutic strategy for preventing or treating obesity.
摘要翻译: 本发明涉及含有具有DGAT抑制活性的化合物(DGAT1抑制活性)或其前药或其药学上可接受的盐作为活性成分的厌食症。 本发明提供一种抗肥胖药物,其是不直接作用于中枢神经系统的厌食症,并且在活性方面令人满意,以及用于预防或治疗肥胖症的治疗策略。
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