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1.Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents 有权
标题翻译: 取代的2-芳基亚氨基杂环和含有它们的组合物,用作孕激素受体结合剂公开(公告)号:US06353006B1
公开(公告)日:2002-03-05
申请号:US09453613
申请日:1999-12-03
申请人: Brian R. Dixon , Cedo M. Bagi , Catherine R. Brennan , David R. Brittelli , William H. Bullock , Jinshan Chen , William L. Collibee , Robert Dally , Jeffrey S. Johnson , Harold C. E. Kluender , William F. Lathrop , Peiying Liu , Carol Ann Mase , Anikó M. Redman , William J. Scott , Klaus Urbahns , Donald J. Wolanin
发明人: Brian R. Dixon , Cedo M. Bagi , Catherine R. Brennan , David R. Brittelli , William H. Bullock , Jinshan Chen , William L. Collibee , Robert Dally , Jeffrey S. Johnson , Harold C. E. Kluender , William F. Lathrop , Peiying Liu , Carol Ann Mase , Anikó M. Redman , William J. Scott , Klaus Urbahns , Donald J. Wolanin
IPC分类号: A01N4340
CPC分类号: C07D263/28 , C07D263/58 , C07D277/18 , C07D277/60 , C07D279/06 , C07D281/02 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10
摘要: This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.
摘要翻译: 本发明涉及2-芳基亚氨基杂环,包括2-芳基亚氨基-1,3-噻唑烷,2-芳基亚氨基-2,3,4,5-四氢-1,3-噻嗪,2-芳基亚氨基-1,3-噻唑烷-2-酮, 4-芳基亚氨基-1,3-噻唑烷-5-酮和2-芳基亚氨基-1,3-恶唑烷,以及它们在调节孕酮受体介导的过程中的用途,以及用于这些疗法的药物组合物。
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2.2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效
标题翻译: 用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号:US06919371B2
公开(公告)日:2005-07-19
申请号:US10666903
申请日:2003-09-17
申请人: Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人: Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号: A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号: C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译: 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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3.2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效
标题翻译: 用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号:US06660752B2
公开(公告)日:2003-12-09
申请号:US10131448
申请日:2002-04-22
申请人: Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人: Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号: A61K3144
CPC分类号: C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译: 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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公开(公告)号:US20060183736A1
公开(公告)日:2006-08-17
申请号:US10521896
申请日:2003-07-16
申请人: Robert Dally , Jeffrey Dodge , Scott Frank , Scott Jones , Timothy Shepherd , Owen Wallace , Kin Fong , Conrad Hummel , George Lewis
发明人: Robert Dally , Jeffrey Dodge , Scott Frank , Scott Jones , Timothy Shepherd , Owen Wallace , Kin Fong , Conrad Hummel , George Lewis
IPC分类号: A61K31/55 , A61K31/453 , A61K31/445 , A61K31/4025 , C07D409/02 , A61K31/40
CPC分类号: C07D295/088 , C07D295/13 , C07D333/56 , C07D333/64 , C07D333/72 , C07D409/02
摘要: The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.
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公开(公告)号:US20120178780A1
公开(公告)日:2012-07-12
申请号:US13424111
申请日:2012-03-19
申请人: Jill E. WOOD , Hanno Wild , Daniel H. Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger A. Smith , Cheri Blum
发明人: Jill E. WOOD , Hanno Wild , Daniel H. Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger A. Smith , Cheri Blum
IPC分类号: A61K31/381 , A61K31/4155 , A61K31/437 , A61K31/34 , A61K31/40 , A61K31/404 , A61K31/427 , A61K31/4025 , C07D333/38 , C07D417/12 , C07D409/12 , C07D307/68 , C07D207/34 , C07D471/04 , A61P35/00 , A61K31/433
CPC分类号: C07D207/34 , C07D307/68 , C07D333/38 , C07D409/12 , C07D417/12 , C07D471/04
摘要: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译: 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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公开(公告)号:US20050272791A1
公开(公告)日:2005-12-08
申请号:US10522227
申请日:2003-07-31
申请人: Rosanne Bonjouklian , Jose De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi , Tiecho Li , Beatriz De Uralde Garmendia , Michal Vieth , Jeremy York , Robert Dally , Miriam Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Shepherd , James Wikel
发明人: Rosanne Bonjouklian , Jose De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi , Tiecho Li , Beatriz De Uralde Garmendia , Michal Vieth , Jeremy York , Robert Dally , Miriam Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Shepherd , James Wikel
IPC分类号: A61K31/41 , A61K31/4184 , A61P35/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D513/04 , C07D43/02
CPC分类号: C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D513/04
摘要: The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis.
摘要翻译: 本发明提供式I的激酶抑制剂:其中W代表由苯基或噻吩取代的咪唑,恶唑,吡唑,噻唑三唑。 所公开的化合物抑制p-38激酶,并且可用于治疗转移或类风湿性关节炎。
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公开(公告)号:US20070213331A1
公开(公告)日:2007-09-13
申请号:US10599129
申请日:2005-04-08
IPC分类号: A61K31/41 , A61K31/53 , C07D295/00 , C07D413/00
CPC分类号: C07D295/00 , C07D207/08 , C07D207/12 , C07D401/12 , C07D403/12 , C07D413/00 , C07D413/04 , C07D413/14
摘要: The present invention provides BACE inhibitors of Formula I: methods for their use and preparation, and intermediates for their preparation.
摘要翻译: 本发明提供式I的BACE抑制剂:其使用和制备方法及其制备中间体。
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8.2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 审中-公开
标题翻译: 用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号:US20050215594A1
公开(公告)日:2005-09-29
申请号:US11117759
申请日:2005-04-28
申请人: Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
发明人: Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
IPC分类号: A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D45/02
CPC分类号: C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译: 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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公开(公告)号:US20070111988A1
公开(公告)日:2007-05-17
申请号:US10597008
申请日:2005-01-18
申请人: Robert Dally , Jeffrey Dodge , Conrad Hummel , Scott Jones , Timothy Shepherd , Owen Wallace , Wayne Weber
发明人: Robert Dally , Jeffrey Dodge , Conrad Hummel , Scott Jones , Timothy Shepherd , Owen Wallace , Wayne Weber
IPC分类号: A61K31/55 , A61K31/453 , C07D409/02 , A61K31/445
CPC分类号: C07D209/46 , C07D209/48 , C07D295/088 , C07D295/192 , C07D307/83 , C07D311/78 , C07D333/64 , C07D409/04
摘要: The present invention relates to a selective estrogen receptor modulators of formula I (I); or a pharmaceutical acid addition salt thereof; and of formula II (II); or a pharmaceutical salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.
摘要翻译: 本发明涉及式I(I)的选择性雌激素受体调节剂; 或其药用酸加成盐; 和式II(II); 或其药学盐; 有用的,例如用于治疗子宫内膜异位症和/或子宫平滑肌瘤/平滑肌瘤。
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公开(公告)号:US06187799B1
公开(公告)日:2001-02-13
申请号:US09083399
申请日:1998-05-22
申请人: Jill E Wood , Hanno Wild , Daniel H Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger A. Smith , Cheri Blum
发明人: Jill E Wood , Hanno Wild , Daniel H Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger A. Smith , Cheri Blum
IPC分类号: A61K3138
CPC分类号: C07D207/34 , C07D307/68 , C07D333/38 , C07D409/12 , C07D417/12 , C07D471/04
摘要: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译: 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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