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公开(公告)号:US09273028B2
公开(公告)日:2016-03-01
申请号:US13882449
申请日:2011-10-28
申请人: Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
发明人: Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
IPC分类号: A01N43/00 , A61K31/00 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D487/04 , C07D519/00 , C07D473/34 , C07D513/04
CPC分类号: A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
摘要: The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供可用作Tec家族激酶抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US20120157443A1
公开(公告)日:2012-06-21
申请号:US13393192
申请日:2010-09-03
申请人: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号: A61K31/553 , C07D487/04 , A61K31/519 , C07D401/04 , A61K31/506 , C07D473/34 , A61K31/52 , C07D417/14 , C07D413/12 , C07D401/14 , A61K31/55 , A61P37/06 , A61P29/00 , A61P35/00 , A61P35/02 , C12N9/99
CPC分类号: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US08785440B2
公开(公告)日:2014-07-22
申请号:US13393192
申请日:2010-09-03
申请人: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号: A61K31/535
CPC分类号: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US20130345192A1
公开(公告)日:2013-12-26
申请号:US13882449
申请日:2011-10-28
申请人: Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
发明人: Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
IPC分类号: C07D401/12 , C07D513/04 , C07D473/34 , C07D471/04 , C07D487/04
CPC分类号: A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
摘要: The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供可用作Tec家族激酶抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US20120157442A1
公开(公告)日:2012-06-21
申请号:US13393191
申请日:2010-09-03
申请人: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
发明人: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC分类号: A61K31/553 , A61K31/519 , A61K31/5377 , C07D401/04 , A61K31/506 , A61P35/02 , A61K31/55 , C12N9/99 , A61P37/06 , A61P29/00 , A61P35/00 , C07D487/04 , C07D471/04
CPC分类号: C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US09029359B2
公开(公告)日:2015-05-12
申请号:US13393191
申请日:2010-09-03
申请人: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
发明人: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC分类号: C07D473/34 , C07D471/04 , C07D239/70 , C07D401/04 , C07D487/04
CPC分类号: C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US20090005359A1
公开(公告)日:2009-01-01
申请号:US12164905
申请日:2008-06-30
申请人: Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人: Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号: A61K31/55 , C07D487/04 , A61K31/551 , A61K31/5377 , A61K31/519
CPC分类号: C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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公开(公告)号:US20120040951A1
公开(公告)日:2012-02-16
申请号:US13142603
申请日:2009-12-30
申请人: Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
发明人: Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
IPC分类号: A61K31/437 , A61K31/5377 , C07D417/14 , A61P35/00 , A61P9/00 , A61P25/28 , A61P37/00 , A61P37/06 , A61P29/00 , A61P31/12 , A61P19/08 , A61P1/16 , A61P7/00 , A61P3/10 , C12N9/99 , C07D471/04
CPC分类号: C07D261/08 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要: The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作Raf蛋白激酶抑制剂的式(I)化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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公开(公告)号:US07968536B2
公开(公告)日:2011-06-28
申请号:US12164905
申请日:2008-06-30
申请人: Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人: Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号: C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/505
CPC分类号: C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要: The present invention provides compounds useful as inhibitors of protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作蛋白激酶抑制剂的化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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公开(公告)号:US08293752B2
公开(公告)日:2012-10-23
申请号:US12164762
申请日:2008-06-30
申请人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号: A61K31/535 , A61K31/52 , C07D239/42 , C07D413/14 , C07D401/14
CPC分类号: C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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