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1.
公开(公告)号:US11299543B2
公开(公告)日:2022-04-12
申请号:US16306282
申请日:2017-06-01
发明人: Benedetto Farsaci , Neil Josephson , Anthony Cao , Ryan Heiser
IPC分类号: C07K16/28 , A61P35/00 , A61K39/395 , A61K39/00
摘要: This disclosure provides methods for treating a tumor in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD30 antibody. In some embodiments, the tumor is derived from a lymphoma (e.g., a Hodgkin lymphoma or a non-Hodgkin lymphoma). In certain embodiments, the anti-CD30 antibody is an antibody-drug conjugate, e.g., brentuximab vedotin.
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公开(公告)号:US20210221901A1
公开(公告)日:2021-07-22
申请号:US16755403
申请日:2018-10-11
发明人: Thomas Manley , Neil Josephson
IPC分类号: C07K16/28 , A61K31/4164 , A61K31/475 , A61K31/704 , A61P35/02 , A61K47/68
摘要: The present disclosure, relates, in general to methods for improving adverse events in subjects receiving treatment with an anti-CD30 antibody drug conjugate, optionally also receiving accompanying chemotherapy. Adverse events include peripheral neuropathy and neutropenia.
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