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公开(公告)号：US20070117782A1
公开(公告)日：2007-05-24
申请号：US11566171
申请日：2006-12-01
申请人： Bruce Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran Moghaddam , Babak Borhan , David Grant , Jessica Greene , Marlene Sisemore , James Sanborn
发明人： Bruce Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran Moghaddam , Babak Borhan , David Grant , Jessica Greene , Marlene Sisemore , James Sanborn
摘要： The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
摘要翻译： 本发明提供在治疗高血压的治疗应用中抑制环氧化物水解酶的化合物。 用于实施本发明的一类优选的化合物具有式1所示的结构，其中Z是氧或硫，W是碳磷或硫，X和Y各自独立地是氮，氧或硫，并且X还可以是碳， R 1至R 4中的至少一个为氢，当X为氮时，R 2为氢，但当X为硫或不存在时不存在 当Y为氮时，氧，R 4为氢，但当Y为硫或氧时不存在，R 1和R 3各自独立地为 C 1 -C 20取代或未取代的烷基，环烷基，芳基，酰基或杂环。
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公开(公告)号：US08815951B2
公开(公告)日：2014-08-26
申请号：US11566171
申请日：2006-12-01
申请人： Bruce D Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran F. Moghaddam , Babak Borhan , David F. Grant , Jessica Greene , Marlene F. Sisemore , James Sanborn
发明人： Bruce D Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran F. Moghaddam , Babak Borhan , David F. Grant , Jessica Greene , Marlene F. Sisemore , James Sanborn
摘要： The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
摘要翻译： 本发明提供在治疗高血压的治疗应用中抑制环氧化物水解酶的化合物。 用于实施本发明的一类优选的化合物具有式1所示的结构，其中Z是氧或硫，W是碳磷或硫，X和Y各自独立地是氮，氧或硫，并且X还可以是碳， 当X为氮时，R 1为R 4为氢，R 2为氢时，当X为硫或氧时不存在，当Y为氮时为R4，当Y为硫或氧时不存在，R 1和R 3为 各自独立地为C1-C20取代或未取代的烷基，环烷基，芳基，酰基或杂环。
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公开(公告)号：US20050067291A1
公开(公告)日：2005-03-31
申请号：US10915401
申请日：2004-08-11
申请人： Kenji Haiki , Kazuhiko Motoba , Hiroshi Oda
发明人： Kenji Haiki , Kazuhiko Motoba , Hiroshi Oda
摘要： A method of producing high purity electrolytic copper through halide-bath electrowinning is provided. The method includes the steps of: growing copper in dendritic form to be deposited on a cathode; and recovering growth ends of 3.0 mm or shorter from the dendrites.
摘要翻译： 提供了一种通过卤化物浴电解冶金生产高纯度电解铜的方法。 该方法包括以下步骤：生长沉淀在阴极上的树枝状铜; 并从枝晶中回收3.0mm或更短的生长末端。
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公开(公告)号：US20050067299A1
公开(公告)日：2005-03-31
申请号：US10896965
申请日：2004-07-23
申请人： Kenji Haiki , Kazuhiko Motoba , Hiroshi Oda
发明人： Kenji Haiki , Kazuhiko Motoba , Hiroshi Oda
CPC分类号： C25C1/12 , C22B11/042 , C22B15/0069 , Y02P10/214 , Y02P10/236
摘要： In a metal-winning method, copper ore or copper-ore concentrates is effectively hydraulically leached in a chloride leach liquor and the resultant leached liquor is diaphragm-electrolyzed. A chloride electrolyte containing Br− ions and the leached metals is subjected to a diaphragm-electrolysis in an electrolytic cell comprising an anode compartment (4) and a cathode compartment (3). A portion of the electrolyte in the anode compartment (4) is withdrawn from below an anode (2) of the anode compartment (4) and is returned to the leaching step so as to increase the oxidation potential of the chloride leach liquor.
摘要翻译： 在金属获取方法中，铜矿石或铜矿精矿在氯化浸出液中有效地液压浸出，所得浸出液进行隔膜电解。 含有Br离子的氯化物电解质和浸出的金属在包括阳极室（4）和阴极室（3）的电解槽中进行隔膜电解。 阳极室（4）中的电解质的一部分从阳极室（4）的阳极（2）的下方排出，并返回到浸出步骤，以增加氯化物浸出液的氧化电位。
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公开(公告)号：US5989430A
公开(公告)日：1999-11-23
申请号：US107327
申请日：1998-06-30
申请人： Kazuhiko Motoba , Katutoshi Narita
发明人： Kazuhiko Motoba , Katutoshi Narita
CPC分类号： B01J45/00
摘要： In a method for recovering antimony from the electrolyte of copper electro-refining process, the antimony is adsorbed on the chelating resin and is then eluted by acid. The eluate is then neutralized to recover antimony. In a conventional method, a large amount of acid and alkali is used. In the inventive eluting method, the antimony concentration in the acidic eluting solution is adjusted to 4 g/L or more in the first step and 3 g/L or less in the second step.
摘要翻译： 在从铜电解法的电解质中回收锑的方法中，锑被吸附在螯合树脂上，然后被酸洗脱。 然后将洗脱液中和以回收锑。 在常规方法中，使用大量的酸和碱。 在本发明的洗脱方法中，酸性洗脱液中的锑浓度在第一步骤中调节至4g / L以上，在第二步骤中调节为3g / L以下。
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公开(公告)号：US07465386B2
公开(公告)日：2008-12-16
申请号：US10896965
申请日：2004-07-23
申请人： Kenji Haiki , Kazuhiko Motoba , Hiroshi Oda
发明人： Kenji Haiki , Kazuhiko Motoba , Hiroshi Oda
CPC分类号： C25C1/12 , C22B11/042 , C22B15/0069 , Y02P10/214 , Y02P10/236
摘要： In a metal-winning method, copper ore or copper-ore concentrates is effectively hydraulically leached in a chloride leach liquor and the resultant leached liquor is diaphragm-electrolyzed. A chloride electrolyte containing Br− ions and the leached metals is subjected to a diaphragm-electrolysis in an electrolytic cell comprising an anode compartment (4) and a cathode compartment (3). A portion of the electrolyte in the anode compartment (4) is withdrawn from below an anode (2) of the anode compartment (4) and is returned to the leaching step so as to increase the oxidation potential of the chloride leach liquor.
摘要翻译： 在金属获取方法中，铜矿石或铜矿精矿在氯化浸出液中有效地液压浸出，所得浸出液进行隔膜电解。 含有Br离子和浸出的金属的氯化物电解质在包括阳极室（4）和阴极室（3）的电解槽中进行隔膜电解。 阳极室（4）中的电解质的一部分从阳极室（4）的阳极（2）的下方排出，并返回到浸出步骤，以增加氯化物浸出液的氧化电位。
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公开(公告)号：US4242314A
公开(公告)日：1980-12-30
申请号：US58771
申请日：1979-07-19
申请人： Kazuhiko Motoba , Eiji Itoh
发明人： Kazuhiko Motoba , Eiji Itoh
CPC分类号： C22B3/0067 , C01G51/003 , Y02P10/234
摘要： Disclosed in the present invention is a process for selectively separating and recovering cobalt by liquid-liquid extraction from an aqueous solution containing cobalt such as those obtained by leaching a cobalt-containing ore with an acid by utilizing an organic solvent containing an alkyl ester of alkylphosphonic acid as the extractant.
摘要翻译： 在本发明中公开了一种通过液体萃取从含有钴的水溶液中选择性分离和回收钴的方法，所述钴水溶液是通过使用含有烷基膦酸烷基酯的有机溶剂，通过用酸浸出含钴矿石而获得的那些 酸作为萃取剂。
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公开(公告)号：US07335289B2
公开(公告)日：2008-02-26
申请号：US10915401
申请日：2004-08-11
申请人： Kenji Haiki , Kazuhiko Motoba , Hiroshi Oda
发明人： Kenji Haiki , Kazuhiko Motoba , Hiroshi Oda
IPC分类号： C25C1/12
摘要： A method of producing high purity electrolytic copper through halide-bath electrowinning is provided. The method includes the steps of: growing copper in dendritic form to be deposited on a cathode; and recovering growth ends of 3.0 mm or shorter from the dendrites.
摘要翻译： 提供了一种通过卤化物浴电解冶金生产高纯度电解铜的方法。 该方法包括以下步骤：生长沉淀在阴极上的树枝状铜; 并从枝晶中回收3.0mm或更短的生长末端。
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