公开(公告)号：US20050111610A1

公开(公告)日：2005-05-26

申请号：US10816064

申请日：2004-04-01

申请人： Bruno Kristiaan De Man ,  Samit Basu ,  Peter Edic ,  Robert Senzig ,  William Ross ,  Xiaoye Wu ,  Colin Wilson ,  Mark Vermilyea ,  Eugene Saragnese

发明人： Bruno Kristiaan De Man ,  Samit Basu ,  Peter Edic ,  Robert Senzig ,  William Ross ,  Xiaoye Wu ,  Colin Wilson ,  Mark Vermilyea ,  Eugene Saragnese

IPC分类号： A61B6/03 ,  G01N23/04 ,  G01T1/29 ,  G21K1/12 ,  A61B6/00 ,  G01N23/00 ,  G01T1/164 ,  H05G1/60

CPC分类号： A61B6/4275 ,  A61B6/027 ,  A61B6/03 ,  A61B6/032 ,  A61B6/4014 ,  G01N23/046 ,  G01N2223/419 ,  G01T1/2985

摘要： Configurations for stationary imaging systems are provided. The configurations may include combinations of various types of distributed sources of X-ray radiation, which generally include addressable emitter elements which may be triggered for emission in desired sequences and combinations. The sources may be ring-like, partial ring-like, or line-like (typically along a Z-axis), and so forth. Combinations of these are envisaged. Corresponding detectors may also be full ring detectors or partial ring detectors associated with the sources to provide sufficient coverage of imaging volumes and to provide the desired mathematical completeness of the collected data.

摘要翻译： 提供固定成像系统的配置。 这些配置可以包括各种类型的分布的X射线辐射源的组合，其通常包括可寻址的发射体元件，其可以以期望的顺序和组合被发射。 源可以是环状，部分环状或线状（通常沿Z轴），等等。 设想这些的组合。 相应的检测器还可以是与源相关联的全环检测器或部分环检测器，以提供成像体积的足够覆盖并提供收集的数据的期望的数学完整性。

公开(公告)号：US20090264753A1

公开(公告)日：2009-10-22

申请号：US12107648

申请日：2008-04-22

申请人： Gustav K. von Schulthess ,  Eugene Saragnese

发明人： Gustav K. von Schulthess ,  Eugene Saragnese

IPC分类号： A61B5/00

CPC分类号： A61B5/055 ,  A61B5/0263 ,  A61B5/02755 ,  A61B5/201 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4244 ,  A61B6/032 ,  A61B6/037 ,  A61B6/5247 ,  A61B8/12 ,  A61B8/5238

摘要： Methods, protocols and systems are provided for multi-modality imaging based on pharmacokinetics of an imaging agent. An imaging agent is introduced into a subject, and is permitted to collect generally in a region of interest (ROI) in the subject until attaining a pseudo-steady state (PSS) distribution within the ROI. The imaging agent records a first functional state of the ROI at a given point in time. A first image data set is obtained with a first imaging modality during a first acquisition time interval that occurs prior or proximate in time with the PSS time interval. The subject is transferred from the first imaging modality to a second imaging modality during a transfer time interval that overlaps the PSS time interval. Once transfer is complete, a second image data set is obtained with the second imaging modality during a second acquisition time interval that also overlaps the PSS time interval in which the imaging agent maintains the PSS distribution in the ROI. In accordance with a protocol, the transfer time interval and second acquisition time interval substantially fall within the PSS time interval. The imaging agent collects in the ROI during an uptake time interval which may or may not precede the time interval during which first imaging modality obtains at least a portion of the first image data set. The second image data set is obtained while the imaging agent persists in the ROI at the PSS distribution reflective of the first functional state even after the ROI is no longer in the first functional state.

摘要翻译： 提供了基于成像剂的药代动力学的多模态成像的方法，方案和系统。 将成像剂引入到受试者中，并且被允许一般地在受试者的感兴趣区域（ROI）中收集，直到在ROI内获得伪稳态（PSS）分布。 成像剂在给定的时间点记录ROI的第一功能状态。 在PSS时间间隔之前或之后发生的第一获取时间间隔期间，利用第一成像模态获得第一图像数据集。 在与PSS时间间隔重叠的传送时间间隔期间，将被摄体从第一成像模式传送到第二成像模式。 一旦传输完成，在第二采集时间间隔期间获得具有第二成像模态的第二图像数据集，其也与成像代理维持ROI中的PSS分布的PSS时间间隔重叠。 根据协议，传送时间间隔和第二获取时间间隔基本上落在PSS时间间隔内。 在摄取时间间隔期间，成像剂在ROI中收集，该摄取时间间隔可以或可以不在第一成像模态获得第一图像数据集的至少一部分的时间间隔之前。 即使在ROI不再处于第一功能状态之后，也可以在反映第一功能状态的PSS分布的影像处理中继续存在ROI，从而获得第二图像数据组。