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    Method for inhibition of necrosis induced by neurotrophin
    1.
    发明申请
    Method for inhibition of necrosis induced by neurotrophin 有权
    抑制神经营养因子诱导坏死的方法

    公开(公告)号：US20060135600A1

    公开(公告)日：2006-06-22

    申请号：US10542936

    申请日：2004-01-20

    申请人： Byoung-Joo Gwag ,  Sung-Hwa Yoon ,  Sun-Hee Kim ,  Seok-Joon Won

    发明人： Byoung-Joo Gwag ,  Sung-Hwa Yoon ,  Sun-Hee Kim ,  Seok-Joon Won

    IPC分类号： A61K31/355

    CPC分类号： A61K31/355 ,  A61K31/00 ,  A61K31/60 ,  A61K31/606 ,  A61K38/185 ,  A61K45/06 ,  A61K2300/00

    摘要： Disclosed is a method for inhibition of necrosis induced by neurotrophin, and more specifically a method for inhibition of necrosis by administrating oxidative stress inhibitor and a method for simultaneous inhibition of necrosis and apoptosis by administrating oxidative stress inhibitor and neurotrophin. The oxidative stress inhibitor of the present invention can inhibit nerve cell necrosis induced by neurotrophin. Moreover, it can be used for protecting nerve cell damage connected with alzheimer disease, parkinson's disease, degenerating cerebropathia and promoting regeneration of the nerve cells by administrating oxidative stress inhibitor and neurotrophin.

    摘要翻译： 本发明公开了抑制神经营养因子诱导的坏死的方法，更具体地，是通过施用氧化应激抑制剂来抑制坏死的方法，以及通过施用氧化应激抑制剂和神经营养因子同时抑制坏死和凋亡的方法。 本发明的氧化应激抑制剂可以抑制神经营养蛋白诱导的神经细胞坏死。 此外，它可用于保护与阿尔茨海默病，帕金森病，退行性脑病有关的神经细胞损伤，并通过施用氧化应激抑制剂和神经营养因子促进神经细胞的再生。