-
公开(公告)号：US4486601A
公开(公告)日：1984-12-04
申请号：US524484
申请日：1983-08-19
IPC分类号： A61K31/19 , A61K31/215 , A61P29/00 , C07C251/44 , C07C131/02
CPC分类号： C07C251/66 , C07C251/68 , C07C255/57 , C07C2103/74
摘要： Esters of 2-adamantanone oxime are prepared and are disclosed as possessing anti-inflammatory activity and antiviral activity against murine hepatitis virus.
摘要翻译： 制备2-金刚烷酮肟的酯，并公开为具有抗小鼠肝炎病毒的抗炎活性和抗病毒活性。
-
公开(公告)号：US4520132A
公开(公告)日：1985-05-28
申请号：US423753
申请日：1982-09-27
IPC分类号： A61K9/08 , A61K31/047 , A61K31/20 , A61P31/12 , C07C57/03
摘要： Warm-blooded animals are treated for Herpes simplex virus-I by administering to the animal a dosage, effective to alleviate the symptoms of the virus, of undecylenic acid and at least one pharmaceutically acceptable carrier, wherein the compound is in the range of from about 1 to about 95% by weight of the composition.
摘要翻译： 通过向动物施用有效减轻病毒症状的剂量的十一碳烯酸和至少一种药学上可接受的载体来治疗单纯疱疹病毒I，其中所述化合物的范围为约 1至约95重量％的组合物。
-
公开(公告)号：US4180583A
公开(公告)日：1979-12-25
申请号：US892636
申请日：1978-04-03
IPC分类号： C07D211/14 , C07D211/70 , A61K27/00 , A61K31/40 , A61K31/445 , A61K31/495
CPC分类号： C07D211/14 , C07D211/70
摘要： Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##STR1## wherein R and R.sup.1 each represent hydrogen; or R and R.sup.1 taken together form a second bond between the carbon atoms bearing R and R.sup.1 ; n is a positive whole integer of from 1 to 3; Y represents --CH.dbd.CH--, or ##STR2## with the proviso that when each of R and R.sup.1 represents hydrogen, Y represents --CH.dbd.CH, and when Y represents --CH.dbd.CH, n is equal to 1 or 2; and Z represents thienyl, phenyl, or substituted phenyl wherein the substituents on the substituted phenyl may be attached at the ortho, meta, or para positions of the phenyl ring and are selected from halogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a lower alkoxy group of from 1 to 4 carbon atoms, di(lower)-alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)-alkylpiperazino. Pharmaceutically acceptable acid addition salts and individual geometric isomers of compounds of the above formula are also included as a part of this invention.
摘要翻译： 可用作抗组胺剂，抗过敏剂和支气管扩张剂的新型化合物由下式表示：其中R和R 1各自表示氢; 或R和R 1一起形成带有R和R 1的碳原子之间的第二键; n为1〜3的正整数， Y表示-CH = CH-或
，条件是当R和R 1各自表示氢时，Y表示-CH = CH，当Y表示-CH = CH时，n等于1或2; 并且Z代表噻吩基，苯基或取代的苯基，其中取代的苯基上的取代基可以在苯环的邻位，间位或对位连接，并且选自卤素，直链或支链的低级烷基链，从1到 4个碳原子，1至4个碳原子的低级烷氧基，二（低级） - 烷基氨基或饱和单环杂环基如吡咯烷子基，哌啶子基，吗啉代或N-（低级） - 烷基哌嗪基。 作为本发明的一部分，还包括上式化合物的药学上可接受的酸加成盐和各个几何异构体。 -
4.发明授权Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions 失效用于治疗组胺诱发的过敏反应症状的组合物和方法
公开(公告)号：US3965257A
公开(公告)日：1976-06-22
申请号：US437161
申请日：1974-01-28
IPC分类号： A61K31/445 , A61K31/535
CPC分类号： A61K31/445
摘要： Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1##Wherein R represents hydrogen or hydroxy; R.sup.1 represents hydrogen; or R and R.sup.1 taken together form a second bond between the carbon atoms bearing R and R.sup.1 ; n is a positive whole integer of from 1 to 3; Z represents thienyl, phenyl, or substituted phenyl wherein the substituents on the substituted phenyl may be attached at the ortho, meta, or para positions of the phenyl ring and are selected from halogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a lower alkoxy group of from 1 to 4 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)alkylpiperazino. Pharmaceutically acceptable acid addition salts and individual optical isomers of compounds of the above formula are also included as a part of this invention.
摘要翻译： 可用作抗组胺剂，抗过敏剂和支气管扩张剂的新型化合物由下式表示，其中R表示氢或羟基; R1表示氢; 或R和R 1一起形成带有R和R 1的碳原子之间的第二键; n为1〜3的正整数， Z表示噻吩基，苯基或取代的苯基，其中取代的苯基上的取代基可以在苯环的邻位，间位或对位连接，并且选自卤素，直链或支链的低级烷基链1至4个 碳原子，1〜4个碳原子的低级烷氧基，二（低级）烷基氨基或饱和单环杂环基如吡咯烷子基，哌啶子基，吗啉代或N-（低级）烷基哌嗪基。 作为本发明的一部分，还包括上式化合物的药学上可接受的酸加成盐和单独的光学异构体。
-
公开(公告)号：USRE32990E
公开(公告)日：1989-07-18
申请号：US115082
申请日：1987-10-29
摘要： Warm-blooded animals are treated for Herpes simplex virus-I by administering to the animal a dosage, effective to alleviate the symptoms of the virus, of undecylenic acid and at least one pharmaceutically acceptable carrier, wherein the compound is in the range of from about 1 to about 95% by weight of the composition.
-
公开(公告)号：US3941795A
公开(公告)日：1976-03-02
申请号：US440855
申请日：1974-02-08
IPC分类号： C07D211/22 , C07D211/70 , C07D409/06
CPC分类号： C07D211/70 , C07D211/22
摘要： Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1##Wherein R.sup.1 represents cyclohexyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl is selected from halogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or a lower alkoxy group of from 1 to 4 carbon atoms; R.sup.2 represents hydrogen or hydroxy; R.sup.3 represents hydrogen, or R.sup.2 and R.sup.3 taken together form a second bond between the carbon atoms bearing R.sup.2 and R.sup.3 ; n is an integer of from 1 to 3; Z represents thienyl, naphthyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl may be attached at the ortho, meta or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, an alkoxy group of from 1 to 6 carbon atoms, a cycloalkyl group of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)-alkylpiperazino with the proviso that when R.sup.1 is phenyl, Z is naphthyl or phenyl substituted with a straight or branched alkyl group of 5 or 6 carbon atoms, a lower alkoxy group of 5 or 6 carbon atoms, or a cycloalkyl group of from 3 to 6 carbon atoms. Pharmaceutically acceptable acid addition salts and individual optical and geometric isomers of compounds of the above formula are also included as a part of this invention.
摘要翻译： 可用作抗组胺剂，抗过敏剂和支气管扩张剂的新型化合物由下式表示：其中R 1表示环己基，苯基或取代的苯基，其中取代的苯基上的取代基选自卤素，1或1的直链或支链低级烷基 至4个碳原子，或1至4个碳原子的低级烷氧基; R2代表氢或羟基; R3表示氢，或R2和R3一起形成带有R2和R3的碳原子之间的第二个键; n为1〜3的整数， Z表示噻吩基，萘基，苯基或取代的苯基，其中取代的苯基上的取代基可以在苯环的邻位，间位或对位连接，并且选自卤素，1至6的直链或支链烷基 碳原子数为1〜6的烷氧基，碳原子数为3〜6的环烷基，二（低级）烷基氨基或饱和单环杂环基如吡咯烷子基，哌啶子基，吗啉代或N-（低级 ） - 烷基哌嗪基，条件是当R 1是苯基时，Z是萘基或被5或6个碳原子的直链或支链烷基，5或6个碳原子的低级烷氧基或3个 至6个碳原子。 作为本发明的一部分，还包括上式化合物的药学上可接受的酸加成盐和单独的光学和几何异构体。
-
公开(公告)号：US3946022A
公开(公告)日：1976-03-23
申请号：US447926
申请日：1974-03-04
IPC分类号： C08L67/00 , C07D211/14 , C07D211/22 , C07D211/70
CPC分类号： C07D211/70 , C07D211/14 , C07D211/22 , Y10S514/826
摘要： Compounds of the following general formula are useful as antihistamine agents, antiallergy agents and bronchodilators: ##SPC1##Wherein R represents hydrogen or hydroxy; R.sup.1 represents hydrogen; or R and R.sup.1 taken together form a second bond between the carbon atoms bearing R and R.sup.1 ; n is the integer 4 or 5; Y represents ##EQU1## or ##EQU2## Z represents phenyl or a substituted phenyl ring wherein the substituent on the substituted phenyl ring is attached at the ortho, meta, or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, alkoxy of from 1 to 6 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group selected from pyrrolidino, piperidino, morpholino or N-(lower)alkyl-piperazino; and pharmaceutically acceptable acid addition salts and individual optical isomers.
摘要翻译： 以下通式的化合物可用作抗组胺剂，抗过敏剂和支气管扩张剂：
-
公开(公告)号：US3931197A
公开(公告)日：1976-01-06
申请号：US440856
申请日：1974-02-08
IPC分类号： C07D211/22 , C07D211/70 , C07D409/06
CPC分类号： C07D211/70 , C07D211/22 , Y10S514/826 , Y10S514/957 , Y10S514/962
摘要： Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1##Wherein R.sup.1 represents cyclohexyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl is selected from halogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or a lower alkoxy group of from 1 to 4 carbon atoms; R.sup.2 represents hydrogen or hydroxy; R.sup.3 represents hydrogen; or R.sup.2 and R.sup.3 taken together form a second bond between the carbon atoms bearing R.sup.2 and R.sup.3 ; n is an integer of from 1 to 3; Z represents thienyl, naphthyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl may be attached at the ortho, meta or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, an alkoxy group of from 1 to 6 carbon atoms, a cycloalkyl group of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)alkylpiperazino with the proviso that when R.sup.1 is phenyl, Z is naphthyl or phenyl substituted with a straight or branched alkyl group of 5 or 6 carbon atoms, a lower alkoxy group of 5 or 6 carbon atoms, or a cycloalkyl group of from 3 to 6 carbon atoms. Pharmaceutically acceptable acid addition salts and individual optical isomers of compounds of the above formula are also included as a part of this invention.
摘要翻译： 可用作抗组胺剂，抗过敏剂和支气管扩张剂的新型化合物由下式表示：其中R 1表示环己基，苯基或取代的苯基，其中取代的苯基上的取代基选自卤素，1或1的直链或支链低级烷基 至4个碳原子，或1至4个碳原子的低级烷氧基; R2代表氢或羟基; R3表示氢; 或R 2和R 3一起形成带有R2和R3的碳原子之间的第二个键; n为1〜3的整数， Z表示噻吩基，萘基，苯基或取代的苯基，其中取代的苯基上的取代基可以在苯环的邻位，间位或对位连接，并且选自卤素，1至6的直链或支链烷基 碳原子数为1〜6的烷氧基，碳原子数为3〜6的环烷基，二（低级）烷基氨基或饱和单环杂环基如吡咯烷子基，哌啶子基，吗啉代或N-（低级 ）烷基哌嗪基，条件是当R 1为苯基时，Z为萘基或被5或6个碳原子的直链或支链烷基取代的苯基，5或6个碳原子的低级烷氧基或3〜 6个碳原子。 作为本发明的一部分，还包括上式化合物的药学上可接受的酸加成盐和单独的光学异构体。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.016 秒)