公开(公告)号：US09883813B2

公开(公告)日：2018-02-06

申请号：US15240725

申请日：2016-08-18

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Qingguo Zeng ,  Rémi DuBois ,  Ping Jia ,  Ryan Bokan ,  Venkatesh Vasudevan ,  Charulatha Ramanathan ,  Maria Strom ,  Brian P. George

IPC分类号： A61B5/044 ,  A61B5/04 ,  A61B5/00 ,  A61B5/0452 ,  A61N1/36 ,  A61B5/046 ,  A61B5/0464 ,  A61B18/14 ,  A61B5/0408 ,  A61B5/042

CPC分类号： A61B5/04012 ,  A61B5/0044 ,  A61B5/04085 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/486 ,  A61B5/7264 ,  A61B18/1492 ,  A61B2576/023 ,  A61N1/36

摘要： A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.

公开(公告)号：US09820666B2

公开(公告)日：2017-11-21

申请号：US14614219

申请日：2015-02-04

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Ryan Bokan ,  Charulatha Ramanathan ,  Ping Jia ,  Maria Strom ,  Qingguo Zeng

IPC分类号： A61B5/044 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/06 ,  A61B5/042

CPC分类号： A61B5/0452 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/06 ,  A61B5/066 ,  A61B5/4836 ,  A61B5/7264 ,  A61B5/743

摘要： A method can include analyzing non-invasive electrical data for a region of interest (ROI) of a patient's anatomical structure to identify one or more zones within the ROI that contain at least one mechanism of distinct arrhythmogenic electrical activity. The method also includes analyzing invasive electrical data for a plurality of signals of interest at different spatial sites within each of the identified zones to determine intracardiac signal characteristics for the plurality of sites within each respective zone. The method also includes generating an output that integrates the at least one mechanism of distinct arrhythmogenic electrical activity for the one or more zones with intracardiac signal characteristics for the plurality of sites within each respective zone.

公开(公告)号：US20160242663A1

公开(公告)日：2016-08-25

申请号：US15048835

申请日：2016-02-19

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Vivek Jayan ,  Ping Jia ,  Ryan Bokan ,  Charu Ramanathan ,  Qingguo Zeng ,  Torsten Konrad

IPC分类号： A61B5/046 ,  A61B5/04 ,  A61B18/12 ,  A61B5/00 ,  A61N1/365 ,  A61B5/0402 ,  A61B5/0408

CPC分类号： A61B5/046 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/18 ,  A61B5/4836 ,  A61B5/7275 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/0072 ,  A61B2018/00767 ,  A61B2018/00994 ,  A61B2018/0212 ,  A61N1/365

摘要： A system includes an input to receive at least one electrophysiological signal representing cardiac electrical activity measured from a body surface of a patient. The system also includes a signal processor to analyze the at least one electrophysiological signal and compute a score having a value to indicate a likelihood of arrhythmogenic activity, the score being computed as a function of at least two of cycle length, amplitude and polarity of the at least one signal.

摘要翻译： 系统包括用于接收表示从患者的身体表面测量的心脏电活动的至少一个电生理信号的输入。 所述系统还包括信号处理器，用于分析所述至少一个电生理信号并计算具有指示致心律失常活动可能性的值的得分，所述评分作为所述周期长度，振幅和极性中的至少两个的函数计算 至少一个信号。

公开(公告)号：US10194982B2

公开(公告)日：2019-02-05

申请号：US15226448

申请日：2016-08-02

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Rémi Dubois ,  Brian P. George ,  Charulatha Ramanathan ,  Qingguo Zeng ,  Maria Strom ,  Venkatesh Vasudevan ,  Ryan Bokan ,  Ping Jia

IPC分类号： A61B18/14 ,  A61B5/044 ,  A61B5/04 ,  A61B5/00 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0408 ,  A61B17/00 ,  A61B18/00

摘要： A non-transitory computer-readable medium can have instructions executable by a processor. The instructions can include an electrogram reconstruction method to generate reconstructed electrogram signals for each of a multitude of points residing on or near a predetermined cardiac envelope based on geometry data and non-invasively measured body surface electrical signals. The instructions can include a phase calculator to compute phase signals for the multitude of points based on the reconstructed electrogram signals and a visualization engine to generate an output based on the computed phase signals.

公开(公告)号：US10004413B2

公开(公告)日：2018-06-26

申请号：US15269396

申请日：2016-09-19

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Ryan Bokan ,  Charulatha Ramanathan ,  Ping Jia ,  Maria Strom

IPC分类号： A61B5/00 ,  A61B5/04 ,  A61B5/042 ,  A61B5/0432 ,  A61B5/044 ,  A61B5/0452 ,  A61B18/06 ,  A61N1/362 ,  A61B18/00

CPC分类号： A61B5/04012 ,  A61B5/0422 ,  A61B5/0432 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6858 ,  A61B5/742 ,  A61B5/748 ,  A61B18/06 ,  A61B2018/00577 ,  A61N1/362

摘要： A method includes storing baseline data representing at least one local or global electrical characteristics for at least a portion of a region of interest (ROI) of a patient's anatomical structure. The baseline data is determined based on electrical measurement data obtained during at least one first measurement interval. The method also includes storing in memory other data representing the at least one local or global electrical characteristics for the at least a portion of the ROI based on electrical measurement data obtained during at least one subsequent measurement interval. The method also includes evaluating the baseline data relative to the other data to determine a change in the at least one local or global electrical characteristics. The method also includes generating an output based on the evaluating to provide an indication of progress or success associated with the applying the treatment.

公开(公告)号：US09977060B2

公开(公告)日：2018-05-22

申请号：US15269488

申请日：2016-09-19

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Brian P. George ,  Charulatha Ramanathan ,  Ping Jia ,  Qingguo Zeng ,  Venkatesh Vasudevan ,  Maria Strom ,  Ryan Bokan ,  Rémi Dubois

IPC分类号： G06F19/00 ,  G01R25/00 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/0428 ,  A61B5/0452 ,  A61B6/00 ,  A61B8/08 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496

CPC分类号： G01R25/00 ,  A61B5/0035 ,  A61B5/0402 ,  A61B5/04085 ,  A61B5/04288 ,  A61B5/04525 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7246 ,  A61B5/7264 ,  A61B6/5247 ,  A61B8/5261

摘要： A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.

公开(公告)号：US09470728B2

公开(公告)日：2016-10-18

申请号：US13890058

申请日：2013-05-08

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Brian P. George ,  Charulatha Ramanathan ,  Ping Jia ,  Qingguo Zeng ,  Venkatesh Vasudevan ,  Maria Strom ,  Ryan Bokan ,  Remi Dubois

IPC分类号： G06F19/00 ,  G01R25/00 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/0408 ,  A61B6/00 ,  A61B8/08 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/0428

CPC分类号： G01R25/00 ,  A61B5/0035 ,  A61B5/0402 ,  A61B5/04085 ,  A61B5/04288 ,  A61B5/04525 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7246 ,  A61B5/7264 ,  A61B6/5247 ,  A61B8/5261

摘要： A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.

摘要翻译： 计算机实现的方法可以包括确定对应于相应节点的多个输入通道中的每一个的幅度。 可以在每个节点的输入通道和其相邻节点的输入通道之间计算相似度。 该方法还可以包括比较每个节点相对于其他节点的振幅以确定暂时的坏信道。 对于每个临时不良通道，可以在每个节点的输入通道和其相邻节点的输入通道之间计算相似度。 然后可以基于所计算的相似度测量来识别信道完整性。

公开(公告)号：US10323922B2

公开(公告)日：2019-06-18

申请号：US14841198

申请日：2015-08-31

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Qingguo Zeng ,  Ping Jia ,  Charulatha Ramanathan ,  Lijun Yu ,  Jeff Burrell ,  Brian George ,  Qing Lou ,  Ryan Bokan ,  Soniya Bhojwani

IPC分类号： G01B7/00 ,  A61B5/08 ,  A61B19/00 ,  A61B5/06

摘要： This disclosure relates to localization and tracking of an object. As one example, measurement data can be stored in memory to represent measured electrical signals at each of a plurality of known measurement locations in a given coordinate system in response to an applied signal at an unknown location in the given coordinate system. A dipole model cost function has parameters representing a dipole location and moment corresponding to the applied signal. A boundary condition can be imposed on the dipole model cost function. The unknown location in the given coordinate system, corresponding to the dipole location, can then be determined based on the stored measurement data and the dipole model cost function with the boundary condition imposed thereon.

公开(公告)号：US10117594B2

公开(公告)日：2018-11-06

申请号：US15240636

申请日：2016-08-18

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Qingguo Zeng ,  Ping Jia ,  Ryan Bokan ,  Brian P. George ,  Charulatha Ramanathan ,  Venkatesh Vasudevan ,  Maria Strom

IPC分类号： A61B5/0452 ,  A61B18/02 ,  A61B18/14 ,  A61B34/10 ,  A61N1/05 ,  A61N1/362 ,  A61N7/00 ,  G06F19/00 ,  G06F17/50 ,  A61B18/04 ,  G16H50/50 ,  A61B18/00

摘要： Systems and methods are provided to detect and analyze arrhythmia drivers. In one example, a system can include a wave front analyzer programmed to compute wave front lines extending over a surface for each of the plurality of time samples based on phase information computed from electrical data at nodes distributed across the surface. A trajectory detector can be programmed to compute wave break points for each of the wave front lines and to determine a trajectory of at least one rotor core across the surface. A stability detector can be programmed to identify at least one stable rotor portion corresponding to subtrajectories of the determined trajectory.

公开(公告)号：US09433364B2

公开(公告)日：2016-09-06

申请号：US14156903

申请日：2014-01-16

申请人： CARDIOINSIGHT TECHNOLOGIES, INC.

发明人： Qingguo Zeng ,  Remi Dubois ,  Ping Jia ,  Ryan Bokan ,  Venkatesh Vasudevan ,  Charulatha Ramanathan ,  Maria Strom ,  Brian P. George

IPC分类号： A61B5/044 ,  A61B5/04 ,  A61B5/00 ,  A61N1/36 ,  A61B5/0452 ,  A61B18/14

摘要： A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.