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公开(公告)号：US11284830B2
公开(公告)日：2022-03-29
申请号：US16774662
申请日：2020-01-28
发明人： Qing Lou , Meredith E. Stone , Qingguo Zeng , Jeffrey B. Adair , Connor S. Edel , Ping Jia , Kevin R. Ponziani , Brian P. George , Ryan M. Bokan , Matthew J. Sabo , Vladimir A. Turovskiy , Ketal C. Patel , Charulatha Ramanathan
IPC分类号： A61B5/364 , A61B5/00 , G16H50/30 , G16H40/63 , A61B5/282 , A61B5/316 , A61B5/333 , A61B5/339 , A61B5/366 , G16H50/20 , A61B5/361 , A61B5/363
摘要： An example method includes analyzing morphology and/or amplitude of each of a plurality of electrophysiological signals across a surface of a patient's body to identify candidate segments of each signal satisfying predetermined conduction pattern criteria. The method also includes determining a conduction timing parameter for each candidate segment in each of the electrophysiological signals.
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公开(公告)号：US10323922B2
公开(公告)日：2019-06-18
申请号：US14841198
申请日：2015-08-31
发明人： Qingguo Zeng , Ping Jia , Charulatha Ramanathan , Lijun Yu , Jeff Burrell , Brian George , Qing Lou , Ryan Bokan , Soniya Bhojwani
摘要： This disclosure relates to localization and tracking of an object. As one example, measurement data can be stored in memory to represent measured electrical signals at each of a plurality of known measurement locations in a given coordinate system in response to an applied signal at an unknown location in the given coordinate system. A dipole model cost function has parameters representing a dipole location and moment corresponding to the applied signal. A boundary condition can be imposed on the dipole model cost function. The unknown location in the given coordinate system, corresponding to the dipole location, can then be determined based on the stored measurement data and the dipole model cost function with the boundary condition imposed thereon.
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公开(公告)号：US10806359B2
公开(公告)日：2020-10-20
申请号：US15498992
申请日：2017-04-27
发明人： Qingguo Zeng , Qing Lou , Ryan M. Bokan , Ping Jia , Connor S. Edel , Charulatha Ramanathan
摘要： One or more non-transitory computer-readable media have instructions executable by a processor and programmed to perform a method. The method includes analyzing the electrical data to locate one or more wave front lines over a given time interval. The electrical data represents electrophysiological signals distributed across a cardiac envelope for one or more time intervals. A respective trajectory is determined for each wave end of each wave front line that is located across the cardiac envelope over the given time interval. A set of connected trajectories are identified based on a duration that the trajectories are connected to each other by a respective wave front line during the given time interval. A connectivity association is characterized for the trajectories in the set of connected trajectories.
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公开(公告)号：US10376173B2
公开(公告)日：2019-08-13
申请号：US15498719
申请日：2017-04-27
发明人： Brian P. George , Meredith E. Stone , Qingguo Zeng , Qing Lou , Connor S. Edel , Ping Jia , Jeffrey B. Adair , Vladimir A. Turovskiy , Matthew J. Sabo , Ryan M. Bokan , Ketal C. Patel , Charulatha Ramanathan , John E. Anderson , Andrew E. Hoover , Cheng Yao
IPC分类号： A61B5/00 , A61B5/0456 , A61B5/04 , A61B5/0408 , A61B5/0452
摘要： An example method includes performing amplitude-based detection to determine location of R-peaks for a plurality of electrograms. The method also includes performing wavelet-based detection to determine location of R-peaks for the plurality of electrograms. The method also includes adjusting the location of the R-peaks determined by the wavelet-based detection of R-peaks based on the location of R-peaks determined by the amplitude-based detection of R-peaks. The method also includes storing, in memory, R-peak location data to specify R-peak locations for the plurality of electrograms based on the adjusting.
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公开(公告)号：US20230036977A1
公开(公告)日：2023-02-02
申请号：US17840256
申请日：2022-06-14
发明人： Qingguo Zeng , Timothy G. Laske , Qing Lou
摘要： In an example, a signal segment evaluator can be programmed to evaluate a morphology of at least one electrophysiological signal to identify a signal segment of interest. The morphology of the signal segment of interest can be indicative of an electrophysiological event of a patient during a respective time interval. A reconstruction engine can be programmed to reconstruct electrophysiological signals on a surface of interest within a body of the patient based on the electrophysiological signals measured from an outer surface of the patient and geometry data representing an anatomy of the patient. A map generator can be programmed to generate a map representing the reconstructed electrophysiological signals on the surface of interest for the respective time interval of the signal segment of interest. A target generator can be programmed to identify a target site within the patient's body based on the map for the electrophysiological event.
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公开(公告)号：US11229392B2
公开(公告)日：2022-01-25
申请号：US16353534
申请日：2019-03-14
发明人： Ping Jia , Qingguo Zeng , Timothy G. Laske , Qing Lou
IPC分类号： A61B5/04 , A61B5/316 , A61B5/00 , A61B5/35 , A61B5/282 , A61B5/287 , A61B5/349 , A61B5/361 , A61B5/363 , A61B5/339
摘要： Systems and methods for cardiac fast firing (e.g., atrial fast firing) detection perform frequency analysis on channels of collected cardiac waveform data and test the data for outlier frequency complex content that is of higher frequency than baseline frequency complex content associated with cardiac fibrillation (e.g., atrial fibrillation) or other arrhythmogenic activity. Anatomical regions from whence the cardiac fast firing originates can be displayed in real time on an epicardial surface map via a graphical display, aiding administration of therapy. Prior to such detection, QRST complex removal can be performed to ensure that ventricular activity does not infect the atrial fast firing analysis. A frequency-based method for QRST complex removal is also disclosed.
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公开(公告)号：US11039776B2
公开(公告)日：2021-06-22
申请号：US15934619
申请日：2018-03-23
发明人： Yong Wang , Qing Lou , Qingguo Zeng , Ping Jia
摘要： This disclosure provides one or more computer-readable media having computer-executable instructions for performing a method. The method includes storing geometry data representing a primary geometry of a cardiac envelope that includes nodes distributed across the cardiac envelope and geometry of a body surface that includes locations where electrical signals are measured. The body surface is spaced apart from the cardiac envelope. The method also includes perturbing the primary geometry of the cardiac envelope a given distance and direction to define the perturbed geometry of the cardiac envelope including nodes spaced from the nodes of the primary geometry. The method also includes computing reconstructed bipolar electrical signals on the nodes of the primary cardiac envelope based on the electrical signals measured from the body surface and the geometry data, including the primary and perturbed geometries of the cardiac envelope.
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公开(公告)号：US11138792B2
公开(公告)日：2021-10-05
申请号：US15943133
申请日：2018-04-02
发明人： Yong Wang , Qingguo Zeng , Ping Jia , Qing Lou
摘要： In an example, an n-dimensional method of fundamental solution (MFS) is used to compute reconstructed electrical activity on a cardiac envelope based on geometry data and electrical data, where n is a positive integer greater than three. The electrical data represents electrical activity measured non-invasively from a plurality of locations distributed on a body surface of a patient, and the geometry data represents three-dimensional body surface geometry for the locations distributed on the body surface where the electrical activity is measured and three-dimensional heart geometry for the cardiac envelope.
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公开(公告)号：US11131536B2
公开(公告)日：2021-09-28
申请号：US16415732
申请日：2019-05-17
发明人： Qingguo Zeng , Ping Jia , Charulatha Ramanathan , Lijun Yu , Jeff Burrell , Brian George , Qing Lou , Ryan Bokan , Soniya Bhojwani
摘要： This disclosure relates to localization and tracking of an object. As one example, measurement data can be stored in memory to represent measured electrical signals at each of a plurality of known measurement locations in a given coordinate system in response to an applied signal at an unknown location in the given coordinate system. A dipole model cost function has parameters representing a dipole location and moment corresponding to the applied signal. A boundary condition can be imposed on the dipole model cost function. The unknown location in the given coordinate system, corresponding to the dipole location, can then be determined based on the stored measurement data and the dipole model cost function with the boundary condition imposed thereon.
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公开(公告)号：US10729345B2
公开(公告)日：2020-08-04
申请号：US15971559
申请日：2018-05-04
发明人： Qing Lou , Jeffrey B. Adair , Qingguo Zeng , Ping Jia , Ryan Bokan , Connor Edel , Rahsean Ellis , Brian P. George , Raja Ghanem , Timothy G. Laske
摘要： For example, one or more non-transitory computer-readable media includes executable instructions to perform a method. The method includes defining a plurality of spatial regions distributed across a geometric surface. At least one wave front that propagates across the geometric surface is detected based on electrical data representing electrophysiological signals for each of a plurality of nodes distributed on the geometric surface over at least one time interval. An indication of conduction velocity of the wave front is determined for at least one spatial region of the plurality of spatial regions during the time interval based on a duration that the wave front resides within the at least one spatial region. Slow conduction activity is identified for the at least one spatial region based on comparing the indication of conduction velocity relative to a threshold. Conduction data is stored in memory to represent each slow conduction event.
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