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公开(公告)号：US11731954B2
公开(公告)日：2023-08-22
申请号：US17227570
申请日：2021-04-12
IPC分类号： C07D405/14 , C07D401/12 , A61P35/00 , C07D401/14 , C07D407/14 , C07D409/14 , C12N9/02
CPC分类号： C07D401/12 , A61P35/00 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C12N9/0071 , C12Y114/11027
摘要： The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds, and compositions (including pharmaceutical compositions) that include these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer or neoplastic disease, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, retinoblastoma, or multiple endocrine neoplasia type 1.
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公开(公告)号：US20210139460A1
公开(公告)日：2021-05-13
申请号：US17097193
申请日：2020-11-13
IPC分类号： C07D401/14 , C07D401/04
摘要： The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.
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公开(公告)号：US10815234B2
公开(公告)日：2020-10-27
申请号：US16790878
申请日：2020-02-14
发明人： Amogh Boloor , Toufike Kanouni , Jeffrey Alan Stafford , James Marvin Veal , Michael Brennan Wallace
IPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US10385047B2
公开(公告)日：2019-08-20
申请号：US15321702
申请日：2015-06-25
IPC分类号： C07D407/12 , C07D417/14 , C07D409/14 , C07D213/79 , C07D401/12 , C07D405/12 , C07D405/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D409/12 , A61P35/00
摘要： The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US10231957B2
公开(公告)日：2019-03-19
申请号：US15996316
申请日：2018-06-01
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04 , A61P35/00
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US20190077758A1
公开(公告)日：2019-03-14
申请号：US16190075
申请日：2018-11-13
发明人： Young K. Chen , Toufike Kanouni , Zhe Nie , Jeffrey Alan Stafford , James Marvin Veal , Michael Brennan Wallace
IPC分类号： C07D213/79 , C07D409/14 , C07D401/04 , C07D213/81 , C07D405/14 , C07D213/74 , C07D401/12 , C07D237/24 , C07D409/12 , C07D405/12
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US20180305336A1
公开(公告)日：2018-10-25
申请号：US16024452
申请日：2018-06-29
IPC分类号： C07D401/12 , C07D413/14 , C07D471/04 , C07D403/12 , C07D401/14 , C07D413/12 , C07D405/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine derivative compounds, substituted 3-aminopyridazine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US10040779B2
公开(公告)日：2018-08-07
申请号：US15446996
申请日：2017-03-01
IPC分类号： C07D401/14 , C07D401/12 , C07D413/12 , C07D405/14 , C07D413/14
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine derivative compounds, substituted 3-aminopyridazine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US20180105521A1
公开(公告)日：2018-04-19
申请号：US15842700
申请日：2017-12-14
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US09873697B2
公开(公告)日：2018-01-23
申请号：US15652174
申请日：2017-07-17
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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