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    Delivery of highly lipophilic agents via medical devices
    2.
    发明授权
    Delivery of highly lipophilic agents via medical devices 有权
    通过医疗器械递送高度亲脂性的药剂

    公开(公告)号：US08257724B2

    公开(公告)日：2012-09-04

    申请号：US11386469

    申请日：2006-03-22

    申请人： Keith R. Cromack ,  John L. Toner ,  Sandra E. Burke ,  Richard W. Krasula ,  Lewis B. Schwartz

    发明人： Keith R. Cromack ,  John L. Toner ,  Sandra E. Burke ,  Richard W. Krasula ,  Lewis B. Schwartz

    IPC分类号： A61F2/00

    CPC分类号： A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/22 ,  A61L2300/416 ,  A61L2300/45

    摘要： An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

    摘要翻译： 一种用于递送与医疗装置相关联的亲脂剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数为统计学上显着的 至少约5,000，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至 课程。 此外，本发明涉及一种用于提高受试者通畅的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。

    COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES
    5.
    发明申请
    COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
    使用医疗器械管理吡虫啉类似物的组合物和方法

    公开(公告)号：US20090162413A1

    公开(公告)日：2009-06-25

    申请号：US12090253

    申请日：2006-10-12

    申请人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

    发明人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

    IPC分类号： A61K9/00 ,  A61K31/337 ,  A61K31/395 ,  A61K31/56 ,  A61P7/02

    CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

    摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

    摘要翻译： 公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。 包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

    MR imaging compositions and methods
    7.
    发明授权
    MR imaging compositions and methods 失效
    MR成像组合物和方法

    公开(公告)号：US5817292A

    公开(公告)日：1998-10-06

    申请号：US960746

    申请日：1992-10-14

    申请人： Robert A. Snow ,  David L. Ladd ,  John L. Toner

    发明人： Robert A. Snow ,  David L. Ladd ,  John L. Toner

    IPC分类号： A61K49/06 ,  A61K49/12 ,  A61K49/00

    CPC分类号： A61K49/128

    摘要： This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.

    摘要翻译： 本发明提供了可用于MR成像的组合物，其包含包含与聚（环氧烷）部分连接的螯合剂残基的单元的聚合物，所述聚合物具有与其相关的参与性金属离子。

    Polymeric x-ray contrast compositions containing iodinated polymeric beads and microcrystaline cellulose
    8.
    发明授权
    Polymeric x-ray contrast compositions containing iodinated polymeric beads and microcrystaline cellulose 失效
    含有碘化聚合物珠粒和微晶纤维素的聚合X射线对比组合物

    公开(公告)号：US5525327A

    公开(公告)日：1996-06-11

    申请号：US227415

    申请日：1994-04-14

    申请人： Edward J. Baker ,  Robert W. Lee ,  Carl R. Illig ,  John L. Toner

    发明人： Edward J. Baker ,  Robert W. Lee ,  Carl R. Illig ,  John L. Toner

    IPC分类号： A61K49/04

    CPC分类号： A61K49/0409 ,  A61K49/04 ,  A61K49/0404 ,  A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000.mu. wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) ##STR1## wherein A is a repeating organic unit in the backbone chain of the polymer; and X is an organic moiety containing or iodinated eromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based or the molecular weight of X, in a pharmaceutically acceptable carrier comprising a cellulose derivative.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的X射线造影剂组合物，其包含粒径为约0.01至约1000μm的碘化聚合物，水不溶性珠粒，其中所述碘化聚合物珠粒包含含有式 （I）其中A是聚合物的主链中的重复有机单元; 并且X是含有或碘化的丙烯酸基团和亲水基团的有机部分，所述部分在药学上可接受的载体中具有在约40至约80重量％的范围内或基于X的分子量的碘含量，其包含纤维素 衍生物。

    Cyclic triamine chelating agents
    9.
    发明授权
    Cyclic triamine chelating agents 失效
    环状三胺螯合剂

    公开(公告)号：US5476644A

    公开(公告)日：1995-12-19

    申请号：US227161

    申请日：1994-04-13

    申请人： Carl R. Illig ,  Thomas J. Caulfield ,  John L. Toner ,  Peng Guo ,  David L. Ladd

    发明人： Carl R. Illig ,  Thomas J. Caulfield ,  John L. Toner ,  Peng Guo ,  David L. Ladd

    IPC分类号： A61K49/00 ,  A61K49/06 ,  C07C227/02 ,  C07C229/16 ,  C07C229/76 ,  C07C237/06 ,  C07C237/08 ,  C07C265/12 ,  C07C327/38 ,  C07C331/28 ,  C07F5/00 ,  C07F9/00 ,  C07F11/00 ,  C07F13/00 ,  C07F15/02 ,  C07F15/04 ,  C07F15/06 ,  C09K3/00 ,  A61K51/00 ,  A61K31/28

    CPC分类号： A61K49/06 ,  C07C229/16 ,  C07C2101/14

    摘要： The present invention provides compounds of the formula ##STR1## chelated with a paramagnetic metal ion wherein Z1 and Z2 each represent the atoms necessary to complete a monocyclic or polycyclic carbocyclic or heterocyclic ring system, said Z1 and Z2 independently optionally substituted with R.sup.6 and R.sup.7, respectively;R.sup.l, R.sup.2, R.sup.3 and R.sup.4 are independently carboxyalkyl (C.sub.1 -C.sub.2), --(CH.sub.2).sub.n --C(.dbd.O)--NH--R.sup.8, or --(CH.sub.2).sub.n --C(.dbd.O)--O--R.sup.8R.sup.5 is carboxyalkyl (C.sub.1 -C.sub.2);R.sup.6 and R.sup.7 are independently hydrogen, benzyl, or benzyloxy, said benzyl or benzyloxy optionally substituted with one, two or three substituents selected from the group consisting of amino, isocyanato (--N.dbd.C.dbd.O), isothiocyanato (--N.dbd.C.dbd.S), --NH--C(.dbd.O)--X or --NH--C(.dbd.S)--X;R.sup.8 is alkyl (C.sub.1 -C.sub.20), --(CH.sub.2).sub.m --Ar, or polyhydroxyalkyl (C.sub.1 -C.sub.20);n is 1 or 2;m is 1 to 15;X is a targeting moiety; andAr is phenyl optionally substituted with one, two or three substituents selected from the group consisting of amino, acylamino, hydroxy, alkyl (C1-C5) and halogen.

    摘要翻译： 本发明提供了与顺磁金属离子螯合的式“IMAGE”化合物，其中Z 1和Z 2各自表示完成单环或多环碳环或杂环系统所必需的原子，所述Z 1和Z 2独立地任选地被R6和R7取代， 分别; R1，R2，R3和R4独立地是羧基烷基（C1-C2）， - （CH2）nC（= O）-NH-R8或 - （CH2）nC（= O）-O-R8 R5是羧基烷基 C2）; R6和R7独立地是氢，苄基或苄氧基，所述苄基或苄氧基任选地被一个，两个或三个选自氨基，异氰酸酯基（-N = C = O），异硫氰酸酯（-N = C = S），-NH-C（= O）-X或-NH-C（= S）-X; R8是烷基（C1-C20）， - （CH2）m-Ar或多羟基烷基（C1-C20）; n为1或2; m为1〜15; X是靶向部分; 并且Ar是任选地被一个，两个或三个选自氨基，酰基氨基，羟基，烷基（C 1 -C 5）和卤素的取代基取代的苯基。