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公开(公告)号:US09187464B2
公开(公告)日:2015-11-17
申请号:US14125378
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: C07D263/02 , A61K31/423 , C07D413/14 , C07D417/14 , C07D495/04 , C07F9/6558 , C07D419/14
CPC分类号: C07D413/14 , C07D417/14 , C07D419/14 , C07D495/04 , C07F9/65583
摘要: The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
摘要翻译: 本发明涉及其中R1,(R2)Y,R3,R4,X和A具有本说明书中给出的含义的式(I)的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物,并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。
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公开(公告)号:US20140121206A1
公开(公告)日:2014-05-01
申请号:US14125378
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: C07D413/14 , C07D495/04 , C07D417/14
CPC分类号: C07D413/14 , C07D417/14 , C07D419/14 , C07D495/04 , C07F9/65583
摘要: The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
摘要翻译: 本发明涉及其中R1,(R2)Y,R3,R4,X和A具有本说明书中给出的含义的式(I)的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物,并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。
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公开(公告)号:US20140113916A1
公开(公告)日:2014-04-24
申请号:US14125370
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: C07D413/14 , C07D413/06
CPC分类号: C07D413/14 , C07D263/52 , C07D413/06 , C07D413/08
摘要: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号:US09487507B2
公开(公告)日:2016-11-08
申请号:US14125370
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: A01N43/76 , A61K31/42 , C07D263/52 , C07D498/00 , C07D413/14 , C07D413/06 , C07D413/08
CPC分类号: C07D413/14 , C07D263/52 , C07D413/06 , C07D413/08
摘要: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号:US08658636B2
公开(公告)日:2014-02-25
申请号:US13635952
申请日:2011-03-23
申请人: Carl A. Brooks , Mui Cheung , Hilary S. Eidam , Ryan M. Fox , Mark A. Hilfiker , Eric S. Manas , Guosen Ye
发明人: Carl A. Brooks , Mui Cheung , Hilary S. Eidam , Ryan M. Fox , Mark A. Hilfiker , Eric S. Manas , Guosen Ye
IPC分类号: C07D401/14 , A61K31/4453 , C07D413/14 , A61K31/5355 , C07D223/02 , A61K31/55 , C07D215/14 , A61P9/00 , A61P11/00 , A61P13/00
CPC分类号: C07D401/06 , C07D401/14
摘要: The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
摘要翻译: 本发明涉及喹啉类似物,含有它们的药物组合物及其作为TRPV4拮抗剂的用途。
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6.Preparation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors 有权
标题翻译: 制备1,6-二取代的氮杂苯并咪唑作为激酶抑制剂公开(公告)号:US07547779B2
公开(公告)日:2009-06-16
申请号:US10574676
申请日:2004-10-06
申请人: Dennis Lee , Robert A. Stavenger , Krista B. Goodman , Mark A. Hilfiker , Haifeng Cui , Andrew Q. Viet , Joseph P. Marino
发明人: Dennis Lee , Robert A. Stavenger , Krista B. Goodman , Mark A. Hilfiker , Haifeng Cui , Andrew Q. Viet , Joseph P. Marino
IPC分类号: C07D413/00 , C07D401/00 , C07D471/02 , C07D491/02
CPC分类号: C07D471/04
摘要: Novel inhibitors of Rho-kinases are disclosed.
摘要翻译: 公开了Rho激酶的新型抑制剂。
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公开(公告)号:US20130012499A1
公开(公告)日:2013-01-10
申请号:US13635952
申请日:2011-03-23
申请人: Carl A. Brooks , Mui Cheung , S. Eidam Hilary , Ryan M. Fox , Mark A. Hilfiker , Eric S. Manas
发明人: Carl A. Brooks , Mui Cheung , S. Eidam Hilary , Ryan M. Fox , Mark A. Hilfiker , Eric S. Manas
IPC分类号: C07D401/14 , C07D413/14 , A61K31/5377 , C07D401/06 , A61P19/02 , A61P9/04 , A61P13/10 , A61P29/00 , A61P9/00 , A61P25/00 , A61K31/4709 , A61K31/55
CPC分类号: C07D401/06 , C07D401/14
摘要: The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
摘要翻译: 本发明涉及喹啉类似物,含有它们的药物组合物及其作为TRPV4拮抗剂的用途。
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8.Preparation of 1,6-Disubstituted Azabenzimidazoles as Kinase Inhibitors 有权
标题翻译: 1,6-二取代偶氮苯并咪唑作为激酶抑制剂的制备公开(公告)号:US20080234261A1
公开(公告)日:2008-09-25
申请号:US10574676
申请日:2004-10-06
申请人: Dennis Lee , Robert A. Stavenger , Krista A. Goodman , Mark A. Hilfiker , Haifeng Cui , Andrew Q. Viet , Joseph P. Marino
发明人: Dennis Lee , Robert A. Stavenger , Krista A. Goodman , Mark A. Hilfiker , Haifeng Cui , Andrew Q. Viet , Joseph P. Marino
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/437 , A61P9/00 , A61K31/496
CPC分类号: C07D471/04
摘要: Novel inhibitors of Rho-kinases are disclosed.
摘要翻译: 公开了Rho激酶的新型抑制剂。
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